Julie Jacob1, Michel Paques2, Valérie Krivosic1, Bénédicte Dupas1, Aude Couturier1, Caroline Kulcsar3, Ramin Tadayoni1, Pascale Massin1, Alain Gaudric4. 1. Assistance Publique-Hôpitaux de Paris AP-HP, Hôpital Lariboisière, Service d'Ophtalmologie, Université Paris Diderot, Sorbonne Paris Cité, Paris, France. 2. Clinical Investigation Center 1423, Centre Hospitalier National des Quinze-Vingts, Institut National de la santé et de la recherche médicale & Université Pierre et Marie Curie, Paris, France. 3. Institut d'Optique Graduate School - Centre National de la Recherche Scientifique - Université Paris 11, Palaiseau, France. 4. Assistance Publique-Hôpitaux de Paris AP-HP, Hôpital Lariboisière, Service d'Ophtalmologie, Université Paris Diderot, Sorbonne Paris Cité, Paris, France. Electronic address: agaudric@gmail.com.
Abstract
PURPOSE: To explore the anatomic correlation of the retinal cone mosaic on adaptive optics images. DESIGN: Retrospective nonconsecutive observational case series. METHODS: A retrospective review of the multimodal imaging charts of 6 patients with focal alteration of the cone mosaic on adaptive optics was performed. Retinal diseases included acute posterior multifocal placoid pigment epitheliopathy (n = 1), hydroxychloroquine retinopathy (n = 1), and macular telangiectasia type 2 (n = 4). High-resolution retinal images were obtained using a flood-illumination adaptive optics camera. Images were recorded using standard imaging modalities: color and red-free fundus camera photography; infrared reflectance scanning laser ophthalmoscopy, fluorescein angiography, indocyanine green angiography, and spectral-domain optical coherence tomography (OCT) images. RESULTS: On OCT, in the marginal zone of the lesions, a disappearance of the interdigitation zone was observed, while the ellipsoid zone was preserved. Image recording demonstrated that such attenuation of the interdigitation zone co-localized with the disappearance of the cone mosaic on adaptive optics images. In 1 case, the restoration of the interdigitation zone paralleled that of the cone mosaic after a 2-month follow-up. CONCLUSION: Our results suggest that the interdigitation zone could contribute substantially to the reflectance of the cone photoreceptor mosaic. The absence of cones on adaptive optics images does not necessarily mean photoreceptor cell death.
PURPOSE: To explore the anatomic correlation of the retinal cone mosaic on adaptive optics images. DESIGN: Retrospective nonconsecutive observational case series. METHODS: A retrospective review of the multimodal imaging charts of 6 patients with focal alteration of the cone mosaic on adaptive optics was performed. Retinal diseases included acute posterior multifocal placoid pigment epitheliopathy (n = 1), hydroxychloroquineretinopathy (n = 1), and macular telangiectasia type 2 (n = 4). High-resolution retinal images were obtained using a flood-illumination adaptive optics camera. Images were recorded using standard imaging modalities: color and red-free fundus camera photography; infrared reflectance scanning laser ophthalmoscopy, fluorescein angiography, indocyanine green angiography, and spectral-domain optical coherence tomography (OCT) images. RESULTS: On OCT, in the marginal zone of the lesions, a disappearance of the interdigitation zone was observed, while the ellipsoid zone was preserved. Image recording demonstrated that such attenuation of the interdigitation zone co-localized with the disappearance of the cone mosaic on adaptive optics images. In 1 case, the restoration of the interdigitation zone paralleled that of the cone mosaic after a 2-month follow-up. CONCLUSION: Our results suggest that the interdigitation zone could contribute substantially to the reflectance of the cone photoreceptor mosaic. The absence of cones on adaptive optics images does not necessarily mean photoreceptor cell death.
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