Ji Won Han1, Doug Hyun Han2, Nicolas Bolo3, BoAh Kim4, Boong Nyun Kim4, Perry F Renshaw5. 1. Department of Psychiatry, Chung Ang University Hospital, Seoul, South Korea. 2. Department of Psychiatry, Chung Ang University Hospital, Seoul, South Korea. Electronic address: hduk@yahoo.com. 3. Department of Psychiatry, Beth Israel Deaconess Medical Center, Harvard Medical School, MA, USA. 4. Department of Psychiatry, Seoul National Hospital, Seoul, South Korea. 5. The Brain Institute, The University of Utah, Salt Lake City, UT, USA.
Abstract
INTRODUCTION: Internet gaming disorder (IGD) and alcohol dependence (AD) have been reported to share clinical characteristics including craving and over-engagement despite negative consequences. However, there are also clinical factors that differ between individuals with IGD and those with AD in terms of chemical intoxication, prevalence age, and visual and auditory stimulation. METHODS: We assessed brain functional connectivity within the prefrontal, striatum, and temporal lobe in 15 patients with IGD and in 16 patients with AD. Symptoms of depression, anxiety, and the attention deficit hyperactivity disorder were assessed in patients with IGD and in patients with AD. RESULTS: Both AD and IGD subjects have positive functional connectivity between the dorsolateral prefrontal cortex (DLPFC), cingulate, and cerebellum. In addition, both groups have negative functional connectivity between the DLPFC and the orbitofrontal cortex. However, the AD subjects have positive functional connectivity between the DLPFC, temporal lobe and striatal areas while IGD subjects have negative functional connectivity between the DLPFC, temporal lobe and striatal areas. CONCLUSIONS: AD and IGD subjects may share deficits in executive function, including problems with self-control and adaptive responding. However, the negative connectivity between the DLPFC and the striatal areas in IGD subjects, different from the connectivity observed in AD subjects, may be due to the earlier prevalence age, different comorbid diseases as well as visual and auditory stimulation.
INTRODUCTION: Internet gaming disorder (IGD) and alcohol dependence (AD) have been reported to share clinical characteristics including craving and over-engagement despite negative consequences. However, there are also clinical factors that differ between individuals with IGD and those with AD in terms of chemical intoxication, prevalence age, and visual and auditory stimulation. METHODS: We assessed brain functional connectivity within the prefrontal, striatum, and temporal lobe in 15 patients with IGD and in 16 patients with AD. Symptoms of depression, anxiety, and the attention deficit hyperactivity disorder were assessed in patients with IGD and in patients with AD. RESULTS: Both AD and IGD subjects have positive functional connectivity between the dorsolateral prefrontal cortex (DLPFC), cingulate, and cerebellum. In addition, both groups have negative functional connectivity between the DLPFC and the orbitofrontal cortex. However, the AD subjects have positive functional connectivity between the DLPFC, temporal lobe and striatal areas while IGD subjects have negative functional connectivity between the DLPFC, temporal lobe and striatal areas. CONCLUSIONS:AD and IGD subjects may share deficits in executive function, including problems with self-control and adaptive responding. However, the negative connectivity between the DLPFC and the striatal areas in IGD subjects, different from the connectivity observed in AD subjects, may be due to the earlier prevalence age, different comorbid diseases as well as visual and auditory stimulation.
Authors: Bharat B Biswal; Maarten Mennes; Xi-Nian Zuo; Suril Gohel; Clare Kelly; Steve M Smith; Christian F Beckmann; Jonathan S Adelstein; Randy L Buckner; Stan Colcombe; Anne-Marie Dogonowski; Monique Ernst; Damien Fair; Michelle Hampson; Matthew J Hoptman; James S Hyde; Vesa J Kiviniemi; Rolf Kötter; Shi-Jiang Li; Ching-Po Lin; Mark J Lowe; Clare Mackay; David J Madden; Kristoffer H Madsen; Daniel S Margulies; Helen S Mayberg; Katie McMahon; Christopher S Monk; Stewart H Mostofsky; Bonnie J Nagel; James J Pekar; Scott J Peltier; Steven E Petersen; Valentin Riedl; Serge A R B Rombouts; Bart Rypma; Bradley L Schlaggar; Sein Schmidt; Rachael D Seidler; Greg J Siegle; Christian Sorg; Gao-Jun Teng; Juha Veijola; Arno Villringer; Martin Walter; Lihong Wang; Xu-Chu Weng; Susan Whitfield-Gabrieli; Peter Williamson; Christian Windischberger; Yu-Feng Zang; Hong-Ying Zhang; F Xavier Castellanos; Michael P Milham Journal: Proc Natl Acad Sci U S A Date: 2010-02-22 Impact factor: 11.205
Authors: Najmeh Khalili-Mahani; Remco M W Zoethout; Christian F Beckmann; Evelinda Baerends; Marieke L de Kam; Roelof P Soeter; Albert Dahan; Mark A van Buchem; Joop M A van Gerven; Serge A R B Rombouts Journal: Hum Brain Mapp Date: 2011-03-09 Impact factor: 5.038
Authors: Brett C Haberstick; Susan E Young; Joanna S Zeiger; Jeffrey M Lessem; John K Hewitt; Christian J Hopfer Journal: Drug Alcohol Depend Date: 2013-12-14 Impact factor: 4.492
Authors: Rhiannon E Mayhugh; Malaak N Moussa; Sean L Simpson; Robert G Lyday; Jonathan H Burdette; Linda J Porrino; Paul J Laurienti Journal: PLoS One Date: 2016-08-05 Impact factor: 3.240
Authors: Su Mi Park; Ji Yoon Lee; Yeon Jin Kim; Jun-Young Lee; Hee Yeon Jung; Bo Kyung Sohn; Dai Jin Kim; Jung-Seok Choi Journal: Sci Rep Date: 2017-05-02 Impact factor: 4.379
Authors: Nannan Pan; Yongxin Yang; Xin Du; Xin Qi; Guijin Du; Yang Zhang; Xiaodong Li; Quan Zhang Journal: Front Psychiatry Date: 2018-03-06 Impact factor: 4.157