Literature DB >> 25280900

Clinical characteristics and current treatment of age-related macular degeneration.

Yoshihiro Yonekawa1, Ivana K Kim1.   

Abstract

Age-related macular degeneration (AMD) is a multifactorial degeneration of photoreceptors and retinal pigment epithelium. The societal impact is significant, with more than 2 million individuals in the United States alone affected by advanced stages of AMD. Recent progress in our understanding of this complex disease and parallel developments in therapeutics and imaging have translated into new management paradigms in recent years. However, there are many unanswered questions, and diagnostic and prognostic precision and treatment outcomes can still be improved. In this article, we discuss the clinical features of AMD, provide correlations with modern imaging and histopathology, and present an overview of treatment strategies.
Copyright © 2015 Cold Spring Harbor Laboratory Press; all rights reserved.

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Year:  2014        PMID： 25280900      PMCID： PMC4292078          DOI： 10.1101/cshperspect.a017178

Source DB:  PubMed          Journal:  Cold Spring Harb Perspect Med        ISSN： 2157-1422            Impact factor:   6.915


  119 in total

1.  Two-year results of photodynamic therapy for polypoidal choroidal vasculopathy.

Authors:  Yumiko Kurashige; Atsushi Otani; Manabu Sasahara; Yuko Yodoi; Hiroshi Tamura; Akitaka Tsujikawa; Nagahisa Yoshimura
Journal:  Am J Ophthalmol       Date:  2008-07-09       Impact factor: 5.258

2.  Aflibercept for the treatment of refractory polypoidal choroidal vasculopathy.

Authors:  Yoshihiro Yonekawa
Journal:  Can J Ophthalmol       Date:  2013-06       Impact factor: 1.882

3.  Management of submacular hemorrhage with intravitreous tissue plasminogen activator injection and pneumatic displacement.

Authors:  A S Hassan; M W Johnson; T E Schneiderman; C D Regillo; P E Tornambe; L S Poliner; B A Blodi; S G Elner
Journal:  Ophthalmology       Date:  1999-10       Impact factor: 12.079

Review 4.  Current concepts in the pathogenesis of age-related macular degeneration.

Authors:  Marco A Zarbin
Journal:  Arch Ophthalmol       Date:  2004-04

5.  Prevalence of age-related macular degeneration in Latinos: the Los Angeles Latino eye study.

Authors:  Rohit Varma; Samantha Fraser-Bell; Sylvia Tan; Ronald Klein; Stanley P Azen
Journal:  Ophthalmology       Date:  2004-07       Impact factor: 12.079

6.  Age-related macular changes in humans over 90 years old.

Authors:  L Feeney-Burns; R P Burns; C L Gao
Journal:  Am J Ophthalmol       Date:  1990-03-15       Impact factor: 5.258

7.  Lutein + zeaxanthin and omega-3 fatty acids for age-related macular degeneration: the Age-Related Eye Disease Study 2 (AREDS2) randomized clinical trial.

Authors: 
Journal:  JAMA       Date:  2013-05-15       Impact factor: 56.272

8.  Intravitreal aflibercept (VEGF trap-eye) in wet age-related macular degeneration.

Authors:  Jeffrey S Heier; David M Brown; Victor Chong; Jean-Francois Korobelnik; Peter K Kaiser; Quan Dong Nguyen; Bernd Kirchhof; Allen Ho; Yuichiro Ogura; George D Yancopoulos; Neil Stahl; Robert Vitti; Alyson J Berliner; Yuhwen Soo; Majid Anderesi; Georg Groetzbach; Bernd Sommerauer; Rupert Sandbrink; Christian Simader; Ursula Schmidt-Erfurth
Journal:  Ophthalmology       Date:  2012-10-17       Impact factor: 12.079

9.  The association of cardiovascular disease with the long-term incidence of age-related maculopathy: the Beaver Dam Eye Study.

Authors:  Ronald Klein; Barbara E K Klein; Sandra C Tomany; Karen J Cruickshanks
Journal:  Ophthalmology       Date:  2003-06       Impact factor: 12.079

10.  Binding and neutralization of vascular endothelial growth factor (VEGF) and related ligands by VEGF Trap, ranibizumab and bevacizumab.

Authors:  Nicholas Papadopoulos; Joel Martin; Qin Ruan; Ashique Rafique; Michael P Rosconi; Ergang Shi; Erica A Pyles; George D Yancopoulos; Neil Stahl; Stanley J Wiegand
Journal:  Angiogenesis       Date:  2012-06       Impact factor: 9.596
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  22 in total

Review 1.  Can innate and autoimmune reactivity forecast early and advance stages of age-related macular degeneration?

Authors:  Grazyna Adamus
Journal:  Autoimmun Rev       Date:  2017-01-28       Impact factor: 9.754

2.  A Deep Phenotype Association Study Reveals Specific Phenotype Associations with Genetic Variants in Age-related Macular Degeneration: Age-Related Eye Disease Study 2 (AREDS2) Report No. 14.

Authors:  Freekje van Asten; Michael Simmons; Ayush Singhal; Tiarnan D Keenan; Rinki Ratnapriya; Elvira Agrón; Traci E Clemons; Anand Swaroop; Zhiyong Lu; Emily Y Chew
Journal:  Ophthalmology       Date:  2017-10-31       Impact factor: 12.079

3.  Serum starvation of ARPE-19 changes the cellular distribution of cholesterol and Fibulin3 in patterns reminiscent of age-related macular degeneration.

Authors:  Dinusha Rajapakse; Katherine Peterson; Sanghamitra Mishra; Graeme Wistow
Journal:  Exp Cell Res       Date:  2017-10-31       Impact factor: 3.905

Review 4.  Nanotechnology in retinal drug delivery.

Authors:  Sibo Jiang; Yesenia L Franco; Yan Zhou; Jianjun Chen
Journal:  Int J Ophthalmol       Date:  2018-06-18       Impact factor: 1.779

5.  Endoilluminator phototoxic maculopathy associated with combined ICG-assisted epiretinal membrane and internal limiting membrane peeling.

Authors:  Yoshihiro Yonekawa; Ashkan M Abbey; Ankoor R Shah; Benjamin J Thomas; Antonio Capone
Journal:  Clin Ophthalmol       Date:  2014-12-09

Review 6.  Cellular reprogramming for understanding and treating human disease.

Authors:  Riya R Kanherkar; Naina Bhatia-Dey; Evgeny Makarev; Antonei B Csoka
Journal:  Front Cell Dev Biol       Date:  2014-11-12

7.  Pathway activation profiling reveals new insights into age-related macular degeneration and provides avenues for therapeutic interventions.

Authors:  Evgeny Makarev; Charles Cantor; Alex Zhavoronkov; Anton Buzdin; Alexander Aliper; Anotonei Benjamin Csoka
Journal:  Aging (Albany NY)       Date:  2014-12       Impact factor: 5.682

Review 8.  Epigenetic Mechanisms of the Aging Human Retina.

Authors:  Katie L Pennington; Margaret M DeAngelis
Journal:  J Exp Neurosci       Date:  2016-02-03

9.  Quality of Life with Macular Degeneration Is Not as Dark as It May Seem: Patients' Perceptions of the MacDQoL Questionnaire.

Authors:  Lisa M Ord; JoAnne Wright; Margaret M DeAngelis; Michael Feehan
Journal:  J Clin Med       Date:  2015-09-22       Impact factor: 4.241

Review 10.  Targeting MAPK Signaling in Age-Related Macular Degeneration.

Authors:  Svetlana V Kyosseva
Journal:  Ophthalmol Eye Dis       Date:  2016-06-23
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