Literature DB >> 2527944

Isolation and characterization of (gamma, delta) CD4+ T cell clones derived from human fetal liver cells.

P Aparicio1, J M Alonso, M L Toribio, M A Marcos, L Pezzi, C Martínez-A.   

Abstract

Lymphocytes isolated from human fetal liver and expanded in vitro in IL-2-containing media reveal the existence of CD4+ gamma, delta T cells. These cells display differential features of double-negative and CD8+ gamma, delta T cells as well as of CD4+ alpha, beta T cells. Thus, they failed to lyse targets in lectin-mediated killing assays and to perform classical helper functions. These results add new information necessary for a better understanding of the physiological role of the gamma, delta T cells.

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Year:  1989        PMID： 2527944      PMCID： PMC2189446          DOI： 10.1084/jem.170.3.1009

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  19 in total

1.  Characteristics of a monoclonal antibody (WT-31) that recognizes a common epitope on the human T cell receptor for antigen.

Authors:  H Spits; J Borst; W Tax; P J Capel; C Terhorst; J E de Vries
Journal:  J Immunol       Date:  1985-09       Impact factor: 5.422

2.  Rearrangement and transcription of a T-cell receptor beta-chain gene in different T-cell subsets.

Authors:  S M Hedrick; R N Germain; M J Bevan; M Dorf; I Engel; P Fink; N Gascoigne; E Heber-Katz; J Kapp; Y Kaufmann
Journal:  Proc Natl Acad Sci U S A       Date:  1985-01       Impact factor: 11.205

3.  Rearrangement and transcription of the beta-chain genes of the T-cell antigen receptor in different types of murine lymphocytes.

Authors:  M Kronenberg; J Goverman; R Haars; M Malissen; E Kraig; L Phillips; T Delovitch; N Suciu-Foca; L Hood
Journal:  Nature       Date:  1985 Feb 21-27       Impact factor: 49.962

4.  Modulation of cytolytic T cell function by lectins.

Authors:  M L Toribio; A de la Hera; P Pereira; M O de Landázuri
Journal:  J Immunol       Date:  1985-04       Impact factor: 5.422

5.  Frontiers of the immune system.

Authors:  C A Janeway
Journal:  Nature       Date:  1988-06-30       Impact factor: 49.962

6.  Complete primary structure of a heterodimeric T-cell receptor deduced from cDNA sequences.

Authors:  H Saito; D M Kranz; Y Takagaki; A C Hayday; H N Eisen; S Tonegawa
Journal:  Nature       Date:  1984 Jun 28-Jul 4       Impact factor: 49.962

7.  Human cytotoxic T cell structures associated with expression of cytolysis. I. Analysis at the clonal cell level of the cytolysis-inhibiting effect of 7 monoclonal antibodies.

Authors:  B Malissen; N Rebai; A Liabeuf; C Mawas
Journal:  Eur J Immunol       Date:  1982-09       Impact factor: 5.532

8.  Regulation of T-cell receptor gamma-chain RNA expression in murine Thy-1+ dendritic epidermal cells.

Authors:  W A Kuziel; A Takashima; M Bonyhadi; P R Bergstresser; J P Allison; R E Tigelaar; P W Tucker
Journal:  Nature       Date:  1987 Jul 16-22       Impact factor: 49.962

9.  Murine intestinal intraepithelial lymphocytes II. Comparison of freshly isolated and cultured intraepithelial lymphocytes.

Authors:  P B Ernst; A Petit; A D Befus; D A Clark; K L Rosenthal; T Ishizaka; J Bienenstock
Journal:  Eur J Immunol       Date:  1985-03       Impact factor: 5.532

10.  Interleukin 2 promotes growth and cytolytic activity in human T3+4-8- thymocytes.

Authors:  A de la Hera; M L Toribio; C Marquez; C Martinez
Journal:  Proc Natl Acad Sci U S A       Date:  1985-09       Impact factor: 11.205
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  5 in total

1.  Development of gammadelta thymocyte subsets during prenatal and postnatal ontogeny.

Authors:  Marek Sinkora; Jana Sinkorová; Wolfgang Holtmeier
Journal:  Immunology       Date:  2005-08       Impact factor: 7.397

2.  Evidence for susceptibility of intrathymic T-cell precursors and their progeny carrying T-cell antigen receptor phenotypes TCR alpha beta + and TCR gamma delta + to human immunodeficiency virus infection: a mechanism for CD4+ (T4) lymphocyte depletion.

Authors:  S M Schnittman; S M Denning; J J Greenhouse; J S Justement; M Baseler; J Kurtzberg; B F Haynes; A S Fauci
Journal:  Proc Natl Acad Sci U S A       Date:  1990-10       Impact factor: 11.205

3.  Involvement of the interleukin 4 pathway in the generation of functional gamma delta T cells from human pro-T cells.

Authors:  A Bárcena; M J Sánchez; J L de la Pompa; M L Toribio; G Kroemer; C Martínez-A
Journal:  Proc Natl Acad Sci U S A       Date:  1991-09-01       Impact factor: 11.205

4.  Human fetal liver gamma/delta T cells predominantly use unusual rearrangements of the T cell receptor delta and gamma loci expressed on both CD4+CD8- and CD4-CD8- gamma/delta T cells.

Authors:  K W Wucherpfennig; Y J Liao; M Prendergast; J Prendergast; D A Hafler; J L Strominger
Journal:  J Exp Med       Date:  1993-02-01       Impact factor: 14.307

Review 5.  The ontogeny of the porcine immune system.

Authors:  Marek Sinkora; John E Butler
Journal:  Dev Comp Immunol       Date:  2008-08-30       Impact factor: 3.636
  5 in total

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