| Literature DB >> 25279163 |
Jiangfang Lian1, Peiliang Fang2, Dongjun Dai3, Yanna Ba2, Xi Yang1, Xiaoyan Huang1, Junxin Li2, Xiaoliang Chen2, Jian Guo2, Feng Guan3, Ping Peng2, Ruochi Zhao3, Shangshi Zhang3, Fang Gao3, Linlin Tang3, Cheng Zhang3, Huihui Ji3, Qingxiao Hong3, Huadan Ye3, Limin Xu3, Qilong Zhong3, Panpan Liu3, Jianqing Zhou1, Shiwei Duan3.
Abstract
Coronary artery disease (CAD) has become the main cause of mortality worldwide. Lectin galactoside-binding soluble-2 (LGALS2) is involved in the cytokine lymphotoxin-α (LTA) cascade that may influence the progress of CAD. The aim of the present study was to assess the association between the LGALS2 3279C>T (rs7291467) polymorphism and CAD. A total of 562 cases and 572 controls were recruited to examine the association. A systematic meta-analysis was performed to evaluate the contribution of LGALS2 3279C>T polymorphism to the risk of CAD among 12,093 cases and 11,020 controls. There was no significant association found in the present case-control study. However, the meta-analysis showed that LGALS2 3279C>T played a protective role in CAD [P=0.008, odds ratio (OR), 0.90; 95% confidence interval (95% CI), 0.82-0.97] and particularly in the Asian population (P=0.006; OR, 0.82; 95% CI, 0.71-0.94). The present case-control study did not find a significant association between LGALS2 3279C>T and CAD in the Eastern Han Chinese population. However, the meta-analysis indicated that LGALS2 3279C>T played a protective role in CAD, suggesting an ethnic difference in the association of the locus with CAD.Entities:
Keywords: coronary artery disease; lectin galactoside-binding soluble-2 3279C>T; meta-analysis; polymorphism; rs7291467
Year: 2014 PMID： 25279163 PMCID： PMC4179692 DOI： 10.3892/br.2014.325
Source DB: PubMed Journal: Biomed Rep ISSN： 2049-9434