Literature DB >> 2527805

Soluble fragments of the low-affinity IgE receptor (CD23) inhibit the spontaneous migration of U937 monocytic cells: neutralization of MIF-activity by a CD23 antibody.

L Flores-Romo1, J A Cairns, M J Millsum, J Gordon.   

Abstract

U937 monocytic cells were found to respond by diminished spontaneous migration when confronted with affinity-purified soluble fragments of the low-affinity receptor for IgE (FcER2/CD23). Unlike B lymphoma cells, U937 cells could not be activated to respond with enhanced DNA synthesis through their membrane-bound CD23 antigen by MHM6, a monoclonal antibody within the CD23 cluster. MHM6 did, however, effectively neutralize the U937-directed MIF (migration inhibition factor) activity contained within the soluble CD23 preparations. The findings not only suggest a role for soluble CD23 as a novel cytokine at sites of inflammation but also indicate different functions for the membrane-bound forms expressed on B cells and monocytes.

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Year:  1989        PMID： 2527805      PMCID： PMC1385331     

Source DB:  PubMed          Journal:  Immunology        ISSN： 0019-2805            Impact factor:   7.397


  13 in total

1.  Regulation of Fc epsilon R2/CD23 gene expression by cytokines and specific ligands (IgE and anti-Fc epsilon R2 monoclonal antibody). Variable regulation depending on the cell types.

Authors:  T Kawabe; M Takami; M Hosoda; Y Maeda; S Sato; M Mayumi; H Mikawa; K Arai; J Yodoi
Journal:  J Immunol       Date:  1988-08-15       Impact factor: 5.422

2.  Establishment and characterization of a human histiocytic lymphoma cell line (U-937).

Authors:  C Sundström; K Nilsson
Journal:  Int J Cancer       Date:  1976-05-15       Impact factor: 7.396

3.  Epstein-Barr virus nuclear antigen 2 specifically induces expression of the B-cell activation antigen CD23.

Authors:  F Wang; C D Gregory; M Rowe; A B Rickinson; D Wang; M Birkenbach; H Kikutani; T Kishimoto; E Kieff
Journal:  Proc Natl Acad Sci U S A       Date:  1987-05       Impact factor: 11.205

4.  Interleukin 5 enhances interleukin 4-induced IgE production by normal human B cells. The role of soluble CD23 antigen.

Authors:  J Pène; F Rousset; F Brière; I Chrétien; J Wideman; J Y Bonnefoy; J E De Vries
Journal:  Eur J Immunol       Date:  1988-06       Impact factor: 5.532

5.  Interferon suppresses antigen- and mitogen-induced leukocyte migration inhibition.

Authors:  R Szigeti; M G Masucci; G Masucci; E Klein; G Klein
Journal:  Nature       Date:  1980-12-11       Impact factor: 49.962

6.  CD23: a multi-functional receptor/lymphokine?

Authors:  J Gordon; L Flores-Romo; J A Cairns; M J Millsum; P J Lane; G D Johnson; I C MacLennan
Journal:  Immunol Today       Date:  1989-05

7.  Molecular structure of human lymphocyte receptor for immunoglobulin E.

Authors:  H Kikutani; S Inui; R Sato; E L Barsumian; H Owaki; K Yamasaki; T Kaisho; N Uchibayashi; R R Hardy; T Hirano
Journal:  Cell       Date:  1986-12-05       Impact factor: 41.582

8.  Triggering of B lymphocytes through CD23: epitope mapping and studies using antibody derivatives indicate an allosteric mechanism of signalling.

Authors:  J Gordon; A J Webb; G R Guy; L Walker
Journal:  Immunology       Date:  1987-04       Impact factor: 7.397

9.  Two species of human Fc epsilon receptor II (Fc epsilon RII/CD23): tissue-specific and IL-4-specific regulation of gene expression.

Authors:  A Yokota; H Kikutani; T Tanaka; R Sato; E L Barsumian; M Suemura; T Kishimoto
Journal:  Cell       Date:  1988-11-18       Impact factor: 41.582

10.  The activation antigen BLAST-2, when shed, is an autocrine BCGF for normal and transformed B cells.

Authors:  S Swendeman; D A Thorley-Lawson
Journal:  EMBO J       Date:  1987-06       Impact factor: 11.598
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  6 in total

1.  Partial characterization of natural and recombinant human soluble CD23.

Authors:  K Rose; G Turcatti; P Graber; S Pochon; P O Regamey; K U Jansen; E Magnenat; N Aubonney; J Y Bonnefoy
Journal:  Biochem J       Date:  1992-09-15       Impact factor: 3.857

2.  Elevated soluble CD23 levels in the sera from patients with localized scleroderma.

Authors:  S Sato; M Fujimoto; K Kikuchi; H Ihn; K Tamaki; K Takehara
Journal:  Arch Dermatol Res       Date:  1996-02       Impact factor: 3.017

3.  Tumour necrosis factor-alpha augments the expression of Fc IgE receptor (Fc epsilon RII/CD23) on human monocytic cell lines and down-regulates interleukin-4-driven Fc epsilon RII expression on monocytes.

Authors:  A Gessl; M Willheim; H Agis; A Spittler; A Schedle; W Krugluger; O Förster; G Boltz-Nitulescu
Journal:  Immunology       Date:  1993-03       Impact factor: 7.397

4.  Native and recombinant soluble CD23 fragments with IgE suppressive activity.

Authors:  M Sarfati; B Bettler; M Letellier; S Fournier; M Rubio-Trujillo; H Hofstetter; G Delespesse
Journal:  Immunology       Date:  1992-08       Impact factor: 7.397

Review 5.  Expression, regulation and function of human Fc epsilon RII (CD23) antigen.

Authors:  M Sarfati; S Fournier; C Y Wu; G Delespesse
Journal:  Immunol Res       Date:  1992       Impact factor: 2.829

6.  Mechanism of formation of human IgE-binding factors (soluble CD23): III. Evidence for a receptor (Fc epsilon RII)-associated proteolytic activity.

Authors:  M Letellier; T Nakajima; G Pulido-Cejudo; H Hofstetter; G Delespesse
Journal:  J Exp Med       Date:  1990-09-01       Impact factor: 14.307
  6 in total

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