Literature DB >> 3038527

The activation antigen BLAST-2, when shed, is an autocrine BCGF for normal and transformed B cells.

S Swendeman, D A Thorley-Lawson.   

Abstract

A shed form of the membrane-bound B cell activation marker, BLAST-2 (Epstein-Barr virus cell surface, CD 23) was immune-affinity purified from Epstein-Barr virus-transformed lymphoblast conditioned medium. SDS-PAGE analysis revealed a complex of two polypeptides, mol. wts 25,000 and 12,000, here termed s-BLAST-2. We show that this complex, when purified to homogeneity, can act as a growth factor for EBV-infected B lymphoblasts and normal receptor-stimulated B cell blasts. It has no effect on resting B or T cells. These data suggest that the BLAST-2 antigen has a role in autocrine B cell growth. Additionally, this complex is a co-mitogen for PHA-stimulated murine thymocytes, a property of interleukin-1.

Entities:  

Mesh：

Substances：

Year:  1987        PMID： 3038527      PMCID： PMC553536          DOI： 10.1002/j.1460-2075.1987.tb02412.x

Source DB:  PubMed          Journal:  EMBO J        ISSN： 0261-4189            Impact factor:   11.598


  36 in total

1.  Growth factors produced by sarcoma virus-transformed cells.

Authors:  G J Todaro; J E De Larco
Journal:  Cancer Res       Date:  1978-11       Impact factor: 12.701

2.  Ligation of the CD23,p45 (BLAST-2,EBVCS) antigen triggers the cell-cycle progression of activated B lymphocytes.

Authors:  J Gordon; M Rowe; L Walker; G Guy
Journal:  Eur J Immunol       Date:  1986-09       Impact factor: 5.532

3.  Epstein-Barr virus superinduces a new human B cell differentiation antigen (B-LAST 1) expressed on transformed lymphoblasts.

Authors:  D A Thorley-Lawson; R T Schooley; A K Bhan; L M Nadler
Journal:  Cell       Date:  1982-09       Impact factor: 41.582

4.  Self-stimulating growth factor production by B-cell lines derived from Burkitt's lymphomas and other lines transformed in vitro by Epstein-Barr virus.

Authors:  B A Blazar; L M Sutton; M Strome
Journal:  Cancer Res       Date:  1983-10       Impact factor: 12.701

5.  Characterization of an antigen whose cell surface expression is induced by infection with Epstein-Barr virus.

Authors:  B Sugden; S Metzenberg
Journal:  J Virol       Date:  1983-06       Impact factor: 5.103

6.  Studies on the capacity of B cells to serve as antigen-presenting cells.

Authors:  R W Chesnut; H M Grey
Journal:  J Immunol       Date:  1981-03       Impact factor: 5.422

7.  Proliferative responses of normal human B lymphocytes. Development of an assay system for human B cell growth factor (BCGF).

Authors:  A Muraguchi; A S Fauci
Journal:  J Immunol       Date:  1982-09       Impact factor: 5.422

8.  The effects of interleukin 1 on human B cell activation and proliferation.

Authors:  R J Falkoff; A Muraguchi; J X Hong; J L Butler; C A Dinarello; A S Fauci
Journal:  J Immunol       Date:  1983-08       Impact factor: 5.422

9.  The role of interleukin 1 in human B cell activation: inhibition of B cell proliferation and the generation of immunoglobulin-secreting cells by an antibody against human leukocytic pyrogen.

Authors:  P E Lipsky; P A Thompson; L J Rosenwasser; C A Dinarello
Journal:  J Immunol       Date:  1983-06       Impact factor: 5.422

10.  B cell activation. I. Anti-immunoglobulin-induced receptor cross-linking results in a decrease in the plasma membrane potential of murine B lymphocytes.

Authors:  J G Monroe; J C Cambier
Journal:  J Exp Med       Date:  1983-06-01       Impact factor: 14.307
View more
  55 in total

1.  Partial characterization of natural and recombinant human soluble CD23.

Authors:  K Rose; G Turcatti; P Graber; S Pochon; P O Regamey; K U Jansen; E Magnenat; N Aubonney; J Y Bonnefoy
Journal:  Biochem J       Date:  1992-09-15       Impact factor: 3.857

Review 2.  Low affinity IgE receptors (Fc epsilon RII).

Authors:  D H Conrad
Journal:  Clin Rev Allergy       Date:  1989

3.  Epstein-Barr virus (EBV) induces expression of B-cell activation markers on in vitro infection of EBV-negative B-lymphoma cells.

Authors:  A Calender; M Billaud; J P Aubry; J Banchereau; M Vuillaume; G M Lenoir
Journal:  Proc Natl Acad Sci U S A       Date:  1987-11       Impact factor: 11.205

4.  The role of lactic acid in autocrine B-cell growth stimulation.

Authors:  S E Pike; S P Markey; C Ijames; K D Jones; G Tosato
Journal:  Proc Natl Acad Sci U S A       Date:  1991-12-15       Impact factor: 11.205

5.  Activity of soluble factors produced by Epstein-Barr virus-transformed human B lymphocytes on different cell lines.

Authors:  C Garzelli; A Bazzichi
Journal:  Experientia       Date:  1991-07-15

Review 6.  Surface molecules involved in B lymphocyte function.

Authors:  P Möller; A Eichelmann; G Moldenhauer
Journal:  Virchows Arch A Pathol Anat Histopathol       Date:  1991

7.  Surface expression and release of soluble forms of CD8 and CD23 in CD40- and IL-4-activated mononuclear cells from patients with Graves' disease (GD).

Authors:  M Itoh; K Uchimura; N Hayakawa; M Makino; R Hayashi; M Nagata; H Kakizawa; A Nagasaka; H Sakamoto; H Kuzuya
Journal:  Clin Exp Immunol       Date:  1998-08       Impact factor: 4.330

8.  Epstein-Barr virus (EBV)-containing nasopharyngeal carcinoma cells express the B-cell activation antigen blast2/CD23 and low levels of the EBV receptor CR2.

Authors:  M Billaud; P Busson; D Huang; N Mueller-Lantzch; G Rousselet; O Pavlish; H Wakasugi; J M Seigneurin; T Tursz; G M Lenoir
Journal:  J Virol       Date:  1989-10       Impact factor: 5.103

Review 9.  Epstein-Barr virus, infectious mononucleosis, and posttransplant lymphoproliferative disorders.

Authors:  M A Nalesnik; T E Starzl
Journal:  Transplant Sci       Date:  1994-09

10.  A role for deregulated c-Myc expression in apoptosis of Epstein-Barr virus-immortalized B cells.

Authors:  B W Cherney; K Bhatia; G Tosato
Journal:  Proc Natl Acad Sci U S A       Date:  1994-12-20       Impact factor: 11.205
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.