| Literature DB >> 25268765 |
Ting Zhou1, Lei Zhao1, Rui Zhan1, Qihua He2, Yawei Tong1, Xiaosheng Tian1, Hecheng Wang1, Tao Zhang1, Yaoyun Fu1, Yang Sun1, Feng Xu3, Xiangyang Guo4, Dongsheng Fan4, Hongbin Han4, Dehua Chui5.
Abstract
Blood-brain barrier (BBB) dysfunction is a key event in the development of many central nervous system (CNS) diseases, such as septic encephalopathy and stroke. 4,4'-Diaminodiphenylsulfone (DDS, Dapsone) has displayed neuroprotective effect, but whether DDS has protective role on BBB integrity is not clear. This study was designed to examine the effect of DDS on lipopolysaccharide (LPS)-induced BBB disruption and oxidative stress in brain vessels. Using in vivo multiphoton imaging, we found that DDS administration significantly restored BBB integrity compromised by LPS. DDS also increased the expression of tight junction proteins occludin, zona occludens-1 (ZO-1) and claudin-5 in brain vessels. Level of reactive oxygen species (ROS) was reduced by DDS treatment, which may due to decreased nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity and NOX2 expression. Our results showed that LPS-induced BBB dysfunction could be attenuated by DDS, indicated that DDS has a therapeutic potential for treating CNS infection and other BBB related diseases.Entities:
Keywords: Blood–brain barrier integrity; Dapsone; Lipopolysaccharide
Mesh：
Substances：
Year: 2014 PMID： 25268765 DOI： 10.1016/j.bbrc.2014.09.093
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575