M B Koontz1, D D Gunzler, L Presley, P M Catalano. 1. Department of Pediatrics, Rainbow Babies & Children's Hospital, Case Western Reserve University, Cleveland, OH, USA.
Abstract
BACKGROUND: Rapid weight gain in infancy has been established as a risk factor for the development of later obesity. OBJECTIVE: We aimed to investigate the role of changes in infant body composition (assessed via total body electrical conductivity) on the development of overweight/obesity in mid-childhood. METHODS: Fifty-three term infants were evaluated at birth, three times during infancy and in mid-childhood. Logistic regression was used to determine associations between rates of total weight gain, fat mass gain and lean mass gain during infancy and later overweight/obesity (defined as body mass index [BMI] ≥85th percentile), adjusted for birth weight and parent education. RESULTS: At follow-up (age 9.0 ± 1.8 years), 30% were overweight/obese. More rapid total weight gain from 0 to 4 months was associated with twofold odds (odds ratio [OR] 1.98, 95% confidence interval [CI] 1.05-3.74, P = 0.04) of overweight/obesity in mid-childhood. From 0 to 8 months, more rapid weight gain was associated with nearly fivefold odds (OR 4.76, 95% CI 1.05-21.5, P = 0.04), and more rapid fat mass gain was associated with eightfold odds (OR 8.03, 95% CI 1.11-58.2, P = 0.04) of later overweight/obesity. CONCLUSION: This exploratory study suggests that rapid weight gain, especially fat mass gain, in earlier infancy predisposes to mid-childhood overweight/obesity.
BACKGROUND: Rapid weight gain in infancy has been established as a risk factor for the development of later obesity. OBJECTIVE: We aimed to investigate the role of changes in infant body composition (assessed via total body electrical conductivity) on the development of overweight/obesity in mid-childhood. METHODS: Fifty-three term infants were evaluated at birth, three times during infancy and in mid-childhood. Logistic regression was used to determine associations between rates of total weight gain, fat mass gain and lean mass gain during infancy and later overweight/obesity (defined as body mass index [BMI] ≥85th percentile), adjusted for birth weight and parent education. RESULTS: At follow-up (age 9.0 ± 1.8 years), 30% were overweight/obese. More rapid total weight gain from 0 to 4 months was associated with twofold odds (odds ratio [OR] 1.98, 95% confidence interval [CI] 1.05-3.74, P = 0.04) of overweight/obesity in mid-childhood. From 0 to 8 months, more rapid weight gain was associated with nearly fivefold odds (OR 4.76, 95% CI 1.05-21.5, P = 0.04), and more rapid fat mass gain was associated with eightfold odds (OR 8.03, 95% CI 1.11-58.2, P = 0.04) of later overweight/obesity. CONCLUSION: This exploratory study suggests that rapid weight gain, especially fat mass gain, in earlier infancy predisposes to mid-childhood overweight/obesity.
Authors: R J Kuczmarski; C L Ogden; L M Grummer-Strawn; K M Flegal; S S Guo; R Wei; Z Mei; L R Curtin; A F Roche; C L Johnson Journal: Adv Data Date: 2000-06-08
Authors: A M Linabery; R W Nahhas; W Johnson; A C Choh; B Towne; A O Odegaard; S A Czerwinski; E W Demerath Journal: Pediatr Obes Date: 2012-10-08 Impact factor: 4.000
Authors: Sani M Roy; David A Fields; Jonathan A Mitchell; Colin P Hawkes; Andrea Kelly; Gary D Wu; Patricia A DeRusso; Michal A Elovitz; Eileen Ford; Danielle Drigo; Babette S Zemel; Shana E McCormack Journal: J Pediatr Date: 2018-09-26 Impact factor: 4.406
Authors: Sonja Entringer; Claudia Buss; Jerod M Rasmussen; Karen Lindsay; Daniel L Gillen; Dan M Cooper; Pathik D Wadhwa Journal: J Clin Endocrinol Metab Date: 2017-04-01 Impact factor: 5.958
Authors: Katherine A Bell; Carol L Wagner; Henry A Feldman; Roman J Shypailo; Mandy B Belfort Journal: Am J Clin Nutr Date: 2017-06-28 Impact factor: 7.045
Authors: P F O'Tierney-Ginn; D Davina; M Gillingham; D J P Barker; C Morris; K L Thornburg Journal: J Dev Orig Health Dis Date: 2017-03-16 Impact factor: 2.401
Authors: Katherine A Bell; Carol L Wagner; Wei Perng; Henry A Feldman; Roman J Shypailo; Mandy B Belfort Journal: J Pediatr Date: 2018-03-15 Impact factor: 4.406
Authors: Kirsten S de Fluiter; Inge A L P van Beijsterveldt; Laura M Breij; Dennis Acton; Anita C S Hokken-Koelega Journal: JAMA Pediatr Date: 2020-12-01 Impact factor: 16.193