Anika K Tandon1, Federico G Velez1, Sherwin J Isenberg1, Joseph L Demer2, Stacy L Pineles3. 1. Department of Ophthalmology, Jules Stein Eye Institute, University of California-Los Angeles, Los Angeles. 2. Department of Ophthalmology, Jules Stein Eye Institute, University of California-Los Angeles, Los Angeles; Department of Neurology, University of California-Los Angeles; Neuroscience Interdepartmental Program, University of California-Los Angeles; Bioengineering Interdepartmental Program, University of California-Los Angeles. 3. Department of Ophthalmology, Jules Stein Eye Institute, University of California-Los Angeles, Los Angeles. Electronic address: pineles@jsei.ucla.edu.
Abstract
PURPOSE: To characterize the relationship between binocular summation (BiS) and binocular inhibition (BI) on the quality of life of adults and children with strabismus. METHODS: Strabismus patients at a single center from 2010 to 2012 were prospectively enrolled. A BiS score was measured using ETDRS and Sloan low-contrast visual acuity (LCA) protocols at 2.5% and 1.25% contrast. Patients were categorized as having BiS (binocular better than better-eye visual acuity by ≥5 letters), BI (binocular worse than better-eye visual acuity by ≥5 letters), or otherwise indeterminate visual acuity (a difference between binocular visual acuity and monocular visual acuity of the better eye of <5 letters). Quality of life was evaluated by the National Eye Institute Visual Functioning Questionnaire 25 (VFQ-25), 20-item Adult Strabismus Questionnaire (AS-20), and the Amblyopia and Strabismus Questionnaire. RESULTS: A total of 108 patients were included. There was no significant BiS or BI for high-contrast ETDRS or 2.5% LCA tests; however, a mean BiS score of -2.14 ± 7.0 letters for 1.25% LCA demonstrated significant binocular inhibition (P = 0.004) for this contrast level. The mean composite VFQ-25 score was significantly lower in subjects with BI on ETDRS (80 ± 19 vs 57 ± 7 for subjects with BiS and BI, resp. [P = 0.03]), 2.5% LCA (81 ± 14 vs 66 ± 16 for subjects with BiS and BI, resp. [P = 0.01]), and 1.25% LCA tests (91 ± 9 vs 72 ± 14 for subjects with BiS and BI, resp. [P = 0.005]). After accounting for potential covariates, significant association persisted for BI, demonstrated by 1.25% LCA (P = 0.01). With BI demonstrable at 2.5%, AS-20 scores were also significantly lower (P = 0.04). CONCLUSIONS: Strabismic patients with BI had significantly lower quality-of -life scores than those who did not, even after accounting for potential covariates and the absence of diplopia.
PURPOSE: To characterize the relationship between binocular summation (BiS) and binocular inhibition (BI) on the quality of life of adults and children with strabismus. METHODS: Strabismus patients at a single center from 2010 to 2012 were prospectively enrolled. A BiS score was measured using ETDRS and Sloan low-contrast visual acuity (LCA) protocols at 2.5% and 1.25% contrast. Patients were categorized as having BiS (binocular better than better-eye visual acuity by ≥5 letters), BI (binocular worse than better-eye visual acuity by ≥5 letters), or otherwise indeterminate visual acuity (a difference between binocular visual acuity and monocular visual acuity of the better eye of <5 letters). Quality of life was evaluated by the National Eye Institute Visual Functioning Questionnaire 25 (VFQ-25), 20-item Adult Strabismus Questionnaire (AS-20), and the Amblyopia and Strabismus Questionnaire. RESULTS: A total of 108 patients were included. There was no significant BiS or BI for high-contrast ETDRS or 2.5% LCA tests; however, a mean BiS score of -2.14 ± 7.0 letters for 1.25% LCA demonstrated significant binocular inhibition (P = 0.004) for this contrast level. The mean composite VFQ-25 score was significantly lower in subjects with BI on ETDRS (80 ± 19 vs 57 ± 7 for subjects with BiS and BI, resp. [P = 0.03]), 2.5% LCA (81 ± 14 vs 66 ± 16 for subjects with BiS and BI, resp. [P = 0.01]), and 1.25% LCA tests (91 ± 9 vs 72 ± 14 for subjects with BiS and BI, resp. [P = 0.005]). After accounting for potential covariates, significant association persisted for BI, demonstrated by 1.25% LCA (P = 0.01). With BI demonstrable at 2.5%, AS-20 scores were also significantly lower (P = 0.04). CONCLUSIONS: Strabismic patients with BI had significantly lower quality-of -life scores than those who did not, even after accounting for potential covariates and the absence of diplopia.
Authors: Stacy L Pineles; Eileen E Birch; Lauren S Talman; David J Sackel; Elliot M Frohman; Peter A Calabresi; Steven L Galetta; Maureen G Maguire; Laura J Balcer Journal: Am J Ophthalmol Date: 2011-05-12 Impact factor: 5.258
Authors: Joost Felius; George R Beauchamp; David R Stager; Elizabeth S Van De Graaf; Huibert J Simonsz Journal: Am J Ophthalmol Date: 2006-10-20 Impact factor: 5.258
Authors: Sarah R Hatt; David A Leske; Elizabeth A Bradley; Stephen R Cole; Jonathan M Holmes Journal: Am J Ophthalmol Date: 2009-07-01 Impact factor: 5.258
Authors: Sarah R Hatt; David A Leske; Elizabeth A Bradley; Stephen R Cole; Jonathan M Holmes Journal: Ophthalmology Date: 2008-11-18 Impact factor: 12.079
Authors: Stacy L Pineles; Joseph L Demer; Sherwin J Isenberg; Eileen E Birch; Federico G Velez Journal: JAMA Ophthalmol Date: 2015-03 Impact factor: 7.389
Authors: Melinda Y Chang; Federico G Velez; Joseph L Demer; Sherwin J Isenberg; Anne L Coleman; Stacy L Pineles Journal: Am J Ophthalmol Date: 2014-12-09 Impact factor: 5.258
Authors: Michael Dorr; MiYoung Kwon; Luis Andres Lesmes; Alexandra Miller; Melanie Kazlas; Kimberley Chan; David G Hunter; Zhong-Lin Lu; Peter J Bex Journal: Front Hum Neurosci Date: 2019-07-12 Impact factor: 3.169