OBJECTIVES: The aim of this study is to evaluate gender-related differences in clinical presentation and mortality in patients undergoing isolated surgical aortic valve replacement (SAVR). METHODS: We performed a retrospective analysis of all patients undergoing isolated SAVR from 2000 to 2011 in our center. Patient data were compared with regard to gender including baseline characteristics, 30-day, and late mortality. Kaplan-Meier survival curves were used to analyze long-term survival up to 10 years follow-up. Independent risk factors for 30-day and late mortality were identified using a Cox regression model. RESULTS: Two thousand one hundred ninety-seven patients were included, 1290 (58.7%) male patients and 907 (41.3%) female patients. Female patients were older (70 ± 11 vs. 64 ± 13 years, p < 0.001), presented with higher logistic EuroSCORE (7.5 ± 5.8 vs. 5.6 ± 6%, p = 0.006), and more common NYHA class III or IV (71 vs. 65%, p = 0.05). Male patients presented more often with LV dysfunction (7.5 vs. 2.8%, p < 0.001) and endocarditis (4.1 vs. 1.7%, p < 0.001) than female patients. Intraoperatively, female patients were more likely to have had a complete sternotomy (65 vs. 52%, p < 0.001) and SAVR with a bioprosthesis (87 vs. 78%, p < 0.001). Female patients exhibited a higher 30-day mortality (4.4 vs. 1.6%, p < 0.001) and late mortality (13 vs. 9.6%, p = 0.04) than male patients. After adjustment for baseline characteristics, only female gender was an independent predictor for 30-day mortality (HR 2.2, 95% CI 0.98 to 5.2, p = 0.05) and age as independent predictor for late mortality (HR 1.07, 95% CI 1.03 to 1.1, p < 0.001). CONCLUSION: Female patients were older and sicker and may therefore exhibit higher 30-day and late mortality than male patients. Female gender per se was a predictor for 30-day but not for late mortality.
OBJECTIVES: The aim of this study is to evaluate gender-related differences in clinical presentation and mortality in patients undergoing isolated surgical aortic valve replacement (SAVR). METHODS: We performed a retrospective analysis of all patients undergoing isolated SAVR from 2000 to 2011 in our center. Patient data were compared with regard to gender including baseline characteristics, 30-day, and late mortality. Kaplan-Meier survival curves were used to analyze long-term survival up to 10 years follow-up. Independent risk factors for 30-day and late mortality were identified using a Cox regression model. RESULTS: Two thousand one hundred ninety-seven patients were included, 1290 (58.7%) male patients and 907 (41.3%) female patients. Female patients were older (70 ± 11 vs. 64 ± 13 years, p < 0.001), presented with higher logistic EuroSCORE (7.5 ± 5.8 vs. 5.6 ± 6%, p = 0.006), and more common NYHA class III or IV (71 vs. 65%, p = 0.05). Male patients presented more often with LV dysfunction (7.5 vs. 2.8%, p < 0.001) and endocarditis (4.1 vs. 1.7%, p < 0.001) than female patients. Intraoperatively, female patients were more likely to have had a complete sternotomy (65 vs. 52%, p < 0.001) and SAVR with a bioprosthesis (87 vs. 78%, p < 0.001). Female patients exhibited a higher 30-day mortality (4.4 vs. 1.6%, p < 0.001) and late mortality (13 vs. 9.6%, p = 0.04) than male patients. After adjustment for baseline characteristics, only female gender was an independent predictor for 30-day mortality (HR 2.2, 95% CI 0.98 to 5.2, p = 0.05) and age as independent predictor for late mortality (HR 1.07, 95% CI 1.03 to 1.1, p < 0.001). CONCLUSION: Female patients were older and sicker and may therefore exhibit higher 30-day and late mortality than male patients. Female gender per se was a predictor for 30-day but not for late mortality.
Authors: Zakeih Chaker; Vinay Badhwar; Fahad Alqahtani; Sami Aljohani; Chad J Zack; David R Holmes; Charanjit S Rihal; Mohamad Alkhouli Journal: J Am Heart Assoc Date: 2017-09-21 Impact factor: 5.501
Authors: Johan Ljungberg; Bengt Johansson; Karl Gunnar Engström; Elin Albertsson; Paul Holmer; Margareta Norberg; Ingvar A Bergdahl; Stefan Söderberg Journal: J Am Heart Assoc Date: 2017-05-05 Impact factor: 5.501
Authors: Anvesha Singh; Tarique Al Musa; Thomas A Treibel; Vassiliou S Vassiliou; Gabriella Captur; Calvin Chin; Laura E Dobson; Silvia Pica; Margaret Loudon; Tamir Malley; Marzia Rigolli; James Robert John Foley; Petra Bijsterveld; Graham R Law; Marc Richard Dweck; Saul G Myerson; Sanjay K Prasad; James C Moon; John P Greenwood; Gerry P McCann Journal: Heart Date: 2019-08-29 Impact factor: 5.994
Authors: Oscar Westin; Marie D Lauridsen; Søren Lund Kristensen; Lars Køber; Christian Torp-Pedersen; Gunnar Gislason; Lars Søndergaard; Mathew S Maurer; Birgitte Pernille Leicht; Finn Gustafsson; Emil L Fosbøl Journal: Int J Cardiol Heart Vasc Date: 2021-03-08
Authors: Richard Paul Steeds; David Messika-Zeitoun; Jeetendra Thambyrajah; Antonio Serra; Eberhard Schulz; Jiri Maly; Marco Aiello; Tanja K Rudolph; Guy Lloyd; Alessandro Santo Bortone; Alberto Clerici; Georg Delle-Karth; Johannes Rieber; Ciro Indolfi; Massimo Mancone; Loic Belle; Alexander Lauten; Martin Arnold; Berto J Bouma; Matthias Lutz; Cornelia Deutsch; Jana Kurucova; Martin Thoenes; Peter Bramlage; Norbert Frey Journal: Open Heart Date: 2021-01
Authors: Farid Foroutan; Gordon H Guyatt; Kathleen O'Brien; Eva Bain; Madeleine Stein; Sai Bhagra; Daegan Sit; Rakhshan Kamran; Yaping Chang; Tahira Devji; Hassan Mir; Veena Manja; Toni Schofield; Reed A Siemieniuk; Thomas Agoritsas; Rodrigo Bagur; Catherine M Otto; Per O Vandvik Journal: BMJ Date: 2016-09-28