Literature DB >> 25263831

Roles of orexins in the regulation of body weight homeostasis.

Takeshi Sakurai1.   

Abstract

Lateral hypothalamic neuropeptides, orexins, have been recognized as one of the most important regulators of sleep/wakefulness states. Besides, these peptides are also regarded as an important factor that regulates feeding behavior, owing to their localization within the lateral hypothalamic area, the classic "feeding center", pharmacological activities, and the fact that prepro-orexin mRNA is upregulated when animals are fasted. This review summarizes the role of orexins in the regulation of feeding behavior and body weight homeostasis in relation to other systems that involve orexinergic neurotransmission.
Copyright © 2013 Asian Oceanian Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Arousal; Body weight; Feeding; Hypothalamus; Orexin

Mesh：

Substances：

Year:  2013        PMID： 25263831     DOI： 10.1016/j.orcp.2013.12.001

Source DB:  PubMed          Journal:  Obes Res Clin Pract        ISSN： 1871-403X            Impact factor:   2.288


  8 in total

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