Yunfei Guo1, David V Conti1, Kai Wang2. 1. Zilkha Neurogenetic Institute, University of Southern California, Los Angeles, CA 90033, Department of Preventive Medicine, USC Keck School of Medicine, Los Angeles, CA 90032 and Department of Psychiatry & Behavioral Sciences, USC Keck School of Medicine, Los Angeles, CA 90033, USA Zilkha Neurogenetic Institute, University of Southern California, Los Angeles, CA 90033, Department of Preventive Medicine, USC Keck School of Medicine, Los Angeles, CA 90032 and Department of Psychiatry & Behavioral Sciences, USC Keck School of Medicine, Los Angeles, CA 90033, USA. 2. Zilkha Neurogenetic Institute, University of Southern California, Los Angeles, CA 90033, Department of Preventive Medicine, USC Keck School of Medicine, Los Angeles, CA 90032 and Department of Psychiatry & Behavioral Sciences, USC Keck School of Medicine, Los Angeles, CA 90033, USA Zilkha Neurogenetic Institute, University of Southern California, Los Angeles, CA 90033, Department of Preventive Medicine, USC Keck School of Medicine, Los Angeles, CA 90032 and Department of Psychiatry & Behavioral Sciences, USC Keck School of Medicine, Los Angeles, CA 90033, USA Zilkha Neurogenetic Institute, University of Southern California, Los Angeles, CA 90033, Department of Preventive Medicine, USC Keck School of Medicine, Los Angeles, CA 90032 and Department of Psychiatry & Behavioral Sciences, USC Keck School of Medicine, Los Angeles, CA 90033, USA.
Abstract
UNLABELLED: Identifying causal variants remains a key challenge in post-GWAS (genome-wide association study) era, as many GWAS single-nucleotide polymorphisms (SNPs) (including imputed ones) fall into non-coding regions, making it difficult to associate statistical significance with predicted functionality. Therefore, we created a web-based tool, Enlight, which overlays functional annotation information, such as histone modification states, methylation patterns, transcription factor binding sites, eQTL and higher-order chromosomal structure, to GWAS results. AVAILABILITY AND IMPLEMENTATION: Accessible by a Web browser at http://enlight.usc.edu.
UNLABELLED: Identifying causal variants remains a key challenge in post-GWAS (genome-wide association study) era, as many GWAS single-nucleotide polymorphisms (SNPs) (including imputed ones) fall into non-coding regions, making it difficult to associate statistical significance with predicted functionality. Therefore, we created a web-based tool, Enlight, which overlays functional annotation information, such as histone modification states, methylation patterns, transcription factor binding sites, eQTL and higher-order chromosomal structure, to GWAS results. AVAILABILITY AND IMPLEMENTATION: Accessible by a Web browser at http://enlight.usc.edu.
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