Literature DB >> 25261266

Hepatitis C virus inhibitory hydrolysable tannins from the fruits of Terminalia chebula.

Olusegun S Ajala1, Azzaya Jukov2, Chao-Mei Ma3.   

Abstract

Two new hydrolysable tannins, chebumeinin A (1) and chebumeinin B (2), together with eight known related compounds (3-10), were isolated from the fruits of Terminalia chebula. The new compounds were structurally determined by analysis of their spectroscopic data and the known compounds characterized by comparing their spectroscopic data with literature values. All isolates were evaluated by an HCV protease inhibition assay, and some compounds were found to be potently active.
Copyright © 2014 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  5-O-galloylshikimic acid (PubChem CID: 460899); Chebulagic acid (PubChem CID: 442674); Chebulic acid (PubChem CID: 71308174); Chebumeinin; Chebumeinin A, chebumeinin B Casuarinin (PubChem CID: 157395); Corilagin (PubChem CID: 73568); Ellagic acid (PubChem CID: 5281855); Gallic acid (PubChem CID: 370); HCV protease inhibition; Hydrolysable tannins; Pentagalloyl glucose (PubChem CID: 65238); Small molecule HCV-protease inhibitors; Terminalia chebula

Mesh：

Substances：

Year:  2014        PMID： 25261266     DOI： 10.1016/j.fitote.2014.09.014

Source DB:  PubMed          Journal:  Fitoterapia        ISSN： 0367-326X            Impact factor:   2.882


  10 in total

1.  Hydrolysable tannin-rich fraction from Terminalia chebula Retz. fruits ameliorates collagen-induced arthritis in BALB/c mice.

Authors:  Sanmuga Priya Ekambaram; Senthamil Selvan Perumal; Thamizharasi Erusappan; Aswini Srinivasan
Journal:  Inflammopharmacology       Date:  2019-08-19       Impact factor: 4.473

2.  Anti-HCV Tannins From Plants Traditionally Used in West Africa and Extracted With Green Solvents.

Authors:  Moussa Bamba; Simon Bordage; Marie-Emmanuelle Sahuc; Sophie Moureu; Jennifer Samaillie; Vincent Roumy; Peggy Vauchel; Krasimir Dimitrov; Yves Rouillé; Jean Dubuisson; Fézan Honora Tra Bi; Karin Séron; Sevser Sahpaz
Journal:  Front Pharmacol       Date:  2022-01-28       Impact factor: 5.810

3.  Studies on the antiviral activity of chebulinic acid against dengue and chikungunya viruses and in silico investigation of its mechanism of inhibition.

Authors:  Naiju Thomas; Poonam Patil; Anjana Sharma; Sandeep Kumar; Vikas Kumar Singh; Kalichamy Alagarasu; Deepti Parashar; Suman Tapryal
Journal:  Sci Rep       Date:  2022-06-21       Impact factor: 4.996

Review 4.  The Genus Terminalia (Combretaceae): An Ethnopharmacological, Phytochemical and Pharmacological Review.

Authors:  Xiao-Rui Zhang; Joseph Sakah Kaunda; Hong-Tao Zhu; Dong Wang; Chong-Ren Yang; Ying-Jun Zhang
Journal:  Nat Prod Bioprospect       Date:  2019-11-06

Review 5.  Antiviral Potential of Selected Medicinal Herbs and Their Isolated Natural Products.

Authors:  W P R T Perera; Janitha A Liyanage; K G C Dissanayake; Hiruni Gunathilaka; W M T D N Weerakoon; D N Wanigasekara; W S K Fernando; R M H Rajapaksha; R P Liyanage; Bingun T Perera
Journal:  Biomed Res Int       Date:  2021-12-08       Impact factor: 3.411

6.  Hepatitis C Virus NS3/4A Inhibition and Host Immunomodulation by Tannins from Terminalia chebula: A Structural Perspective.

Authors:  Vishal S Patil; Darasaguppe R Harish; Umashankar Vetrivel; Subarna Roy; Sanjay H Deshpande; Harsha V Hegde
Journal:  Molecules       Date:  2022-02-05       Impact factor: 4.927

Review 7.  Phytotherapeutic Approaches to the Prevention of Age-Related Changes and the Extension of Active Longevity.

Authors:  Olga Babich; Viktoria Larina; Svetlana Ivanova; Andrei Tarasov; Maria Povydysh; Anastasiya Orlova; Jovana Strugar; Stanislav Sukhikh
Journal:  Molecules       Date:  2022-03-31       Impact factor: 4.411

8.  Hepato-protective effects and chemical constituents of a bioactive fraction of the traditional compound medicine-Gurigumu-7.

Authors:  Haiyan Xu; Qiong Ma; Jiannan Ma; Zhigang Wu; Yali Wang; Chaomei Ma
Journal:  BMC Complement Altern Med       Date:  2016-06-13       Impact factor: 3.659

Review 9.  A Review on Potential Mechanisms of Terminalia chebula in Alzheimer's Disease.

Authors:  Amir R Afshari; Hamid R Sadeghnia; Hamid Mollazadeh
Journal:  Adv Pharmacol Sci       Date:  2016-01-28

Review 10.  A Comprehensive Review of the Structure Elucidation of Tannins from Terminalia Linn.

Authors:  Zihao Chang; Qiunan Zhang; Wenyi Liang; Kun Zhou; Ping Jian; Gaimei She; Lanzhen Zhang
Journal:  Evid Based Complement Alternat Med       Date:  2019-11-15       Impact factor: 2.629
  10 in total

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