A De Ciantis1, A J Barkovich2, M Cosottini3, C Barba1, D Montanaro4, M Costagli5, M Tosetti5, L Biagi5, W B Dobyns6, R Guerrini7. 1. From the Pediatric Neurology Unit (A.D.C., C.B., R.G.), Meyer Children's Hospital, University of Florence, Florence, Italy. 2. Department of Radiology and Biomedical Imaging (A.J.B.), University of California San Francisco, San Francisco, California. 3. Department of Translational Research and New Technologies in Medicine and Surgery (M. Cosottini), University of Pisa, Pisa, Italy IMAGO7 Foundation (M. Cosottini), Pisa, Italy. 4. Fondazione Consiglio Nazionale delle Ricerche/Regione Toscana (D.M.), Unità Operativa Semplice Neuroradiologia, Pisa, Italy. 5. Istituto di Ricovero e Cura a Carattere Scientifico Stella Maris Foundation (M. Costagli, M.T., L.B., R.G.), Pisa, Italy. 6. Center for Integrative Brain Research (W.B.D.), Seattle Children's Hospital, Seattle, Washington. 7. From the Pediatric Neurology Unit (A.D.C., C.B., R.G.), Meyer Children's Hospital, University of Florence, Florence, Italy Istituto di Ricovero e Cura a Carattere Scientifico Stella Maris Foundation (M. Costagli, M.T., L.B., R.G.), Pisa, Italy renzo.guerrini@unifi.it.
Abstract
BACKGROUND AND PURPOSE: Polymicrogyria is a malformation of cortical development that is often identified in children with epilepsy or delayed development. We investigated in vivo the potential of 7T imaging in characterizing polymicrogyria to determine whether additional features could be identified. MATERIALS AND METHODS: Ten adult patients with polymicrogyria previously diagnosed by using 3T MR imaging underwent additional imaging at 7T. We assessed polymicrogyria according to topographic pattern, extent, symmetry, and morphology. Additional imaging sequences at 7T included 3D T2* susceptibility-weighted angiography and 2D tissue border enhancement FSE inversion recovery. Minimum intensity projections were used to assess the potential of the susceptibility-weighted angiography sequence for depiction of cerebral veins. RESULTS: At 7T, we observed perisylvian polymicrogyria that was bilateral in 6 patients, unilateral in 3, and diffuse in 1. Four of the 6 bilateral abnormalities had been considered unilateral at 3T. While 3T imaging revealed 2 morphologic categories (coarse, delicate), 7T susceptibility-weighted angiography images disclosed a uniform ribbonlike pattern. Susceptibility-weighted angiography revealed numerous dilated superficial veins in all polymicrogyric areas. Tissue border enhancement imaging depicted a hypointense line corresponding to the gray-white interface, providing a high definition of the borders and, thereby, improving detection of the polymicrogyric cortex. CONCLUSIONS: 7T imaging reveals more anatomic details of polymicrogyria compared with 3T conventional sequences, with potential implications for diagnosis, genetic studies, and surgical treatment of associated epilepsy. Abnormalities of cortical veins may suggest a role for vascular dysgenesis in pathogenesis.
BACKGROUND AND PURPOSE: Polymicrogyria is a malformation of cortical development that is often identified in children with epilepsy or delayed development. We investigated in vivo the potential of 7T imaging in characterizing polymicrogyria to determine whether additional features could be identified. MATERIALS AND METHODS: Ten adult patients with polymicrogyria previously diagnosed by using 3T MR imaging underwent additional imaging at 7T. We assessed polymicrogyria according to topographic pattern, extent, symmetry, and morphology. Additional imaging sequences at 7T included 3D T2* susceptibility-weighted angiography and 2D tissue border enhancement FSE inversion recovery. Minimum intensity projections were used to assess the potential of the susceptibility-weighted angiography sequence for depiction of cerebral veins. RESULTS: At 7T, we observed perisylvian polymicrogyria that was bilateral in 6 patients, unilateral in 3, and diffuse in 1. Four of the 6 bilateral abnormalities had been considered unilateral at 3T. While 3T imaging revealed 2 morphologic categories (coarse, delicate), 7T susceptibility-weighted angiography images disclosed a uniform ribbonlike pattern. Susceptibility-weighted angiography revealed numerous dilated superficial veins in all polymicrogyric areas. Tissue border enhancement imaging depicted a hypointense line corresponding to the gray-white interface, providing a high definition of the borders and, thereby, improving detection of the polymicrogyric cortex. CONCLUSIONS: 7T imaging reveals more anatomic details of polymicrogyria compared with 3T conventional sequences, with potential implications for diagnosis, genetic studies, and surgical treatment of associated epilepsy. Abnormalities of cortical veins may suggest a role for vascular dysgenesis in pathogenesis.
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Authors: K V Annink; N E van der Aa; J Dudink; T Alderliesten; F Groenendaal; M Lequin; F E Jansen; K S Rhebergen; P Luijten; J Hendrikse; H J M Hoogduin; E R Huijing; E Versteeg; F Visser; A J E Raaijmakers; E C Wiegers; D W J Klomp; J P Wijnen; M J N L Benders Journal: AJNR Am J Neuroradiol Date: 2020-07-30 Impact factor: 3.825
Authors: Doris D Wang; Renatta Knox; John D Rolston; Dario J Englot; A James Barkovich; Tarik Tihan; Kurtis I Auguste; Robert C Knowlton; Susannah B Cornes; Edward F Chang Journal: Epilepsia Date: 2015-12-09 Impact factor: 5.864