PURPOSE: Few studies have estimated population prevalence and morbidity of primary immunodeficiency diseases (PIDD). We used administrative healthcare databases to estimate the prevalence of PIDD diagnoses in the United States from 2001 to 2007. METHODS: MarketScan databases compile claims from commercial health insurance plans and Medicaid, recording individual diagnoses for outpatient encounters and hospital stays. We used a cross sectional survey to estimate prevalence of PIDD using related ICD-9 codes (279.0, 279.1, 279.2, 279.8, 279.9, 288.1 and 288.2). Persons with secondary immunodeficiency diagnoses were excluded from analysis. RESULTS: Between 2001 and 2007, prevalence of any PIDD diagnosis increased from 38.9 to 50.5 per 100,000 among privately insured and from 29.1 to 41.1 per 100,000 among publicly insured persons. B cell defects predominated. Prevalence was more than twice as high among Whites as among Blacks or Hispanics. CONCLUSION: In this large database, we found a higher prevalence of diagnosed PIDD than has been reported previously from registries. Increased awareness may have contributed to the increasing prevalence.
PURPOSE: Few studies have estimated population prevalence and morbidity of primary immunodeficiency diseases (PIDD). We used administrative healthcare databases to estimate the prevalence of PIDD diagnoses in the United States from 2001 to 2007. METHODS: MarketScan databases compile claims from commercial health insurance plans and Medicaid, recording individual diagnoses for outpatient encounters and hospital stays. We used a cross sectional survey to estimate prevalence of PIDD using related ICD-9 codes (279.0, 279.1, 279.2, 279.8, 279.9, 288.1 and 288.2). Persons with secondary immunodeficiency diagnoses were excluded from analysis. RESULTS: Between 2001 and 2007, prevalence of any PIDD diagnosis increased from 38.9 to 50.5 per 100,000 among privately insured and from 29.1 to 41.1 per 100,000 among publicly insured persons. B cell defects predominated. Prevalence was more than twice as high among Whites as among Blacks or Hispanics. CONCLUSION: In this large database, we found a higher prevalence of diagnosed PIDD than has been reported previously from registries. Increased awareness may have contributed to the increasing prevalence.
Authors: J A Winkelstein; M C Marino; R B Johnston; J Boyle; J Curnutte; J I Gallin; H L Malech; S M Holland; H Ochs; P Quie; R H Buckley; C B Foster; S J Chanock; H Dickler Journal: Medicine (Baltimore) Date: 2000-05 Impact factor: 1.889
Authors: Corinne Antoine; Susanna Müller; Andrew Cant; Marina Cavazzana-Calvo; Paul Veys; Jaak Vossen; Anders Fasth; Carsten Heilmann; Nicolas Wulffraat; Reinhard Seger; Stéphane Blanche; Wilhelm Friedrich; Mario Abinun; Graham Davies; Robert Bredius; Ansgar Schulz; Paul Landais; Alain Fischer Journal: Lancet Date: 2003-02-15 Impact factor: 79.321
Authors: Jerry A Winkelstein; Mary C Marino; Hans Ochs; Ramsey Fuleihan; Paul R Scholl; Raif Geha; E Richard Stiehm; Mary Ellen Conley Journal: Medicine (Baltimore) Date: 2003-11 Impact factor: 1.889
Authors: Mary Lou Lindegren; Lisa Kobrynski; Sonja A Rasmussen; Cynthia A Moore; Scott D Grosse; Marsha Lynne Vanderford; Thomas J Spira; J Steven McDougal; Robert F Vogt; W Harry Hannon; Lisa V Kalman; Bin Chen; Marifran Mattson; Timothy G Baker; Muin Khoury Journal: MMWR Recomm Rep Date: 2004-01-16
Authors: Hillary Hernandez-Trujillo; Jordan S Orange; Jason A Roy; Yanli Wang; Craig N Newcomb; Qing Liu; Sean Hennessy; Vincent Lo Re Journal: J Clin Immunol Date: 2015-08-14 Impact factor: 8.317
Authors: Samuele Renzi; Karin Petra Sabine Langenberg-Ververgaert; Nicolas Waespe; Salah Ali; Jack Bartram; Orli Michaeli; Julia Upton; Michaela Cada Journal: Eur J Pediatr Date: 2020-03-11 Impact factor: 3.183
Authors: Kathleen E Sullivan; Hamid Bassiri; Ahmed A Bousfiha; Beatriz T Costa-Carvalho; Alexandra F Freeman; David Hagin; Yu L Lau; Michail S Lionakis; Ileana Moreira; Jorge A Pinto; M Isabel de Moraes-Pinto; Amit Rawat; Shereen M Reda; Saul Oswaldo Lugo Reyes; Mikko Seppänen; Mimi L K Tang Journal: J Clin Immunol Date: 2017-08-07 Impact factor: 8.317
Authors: Dimana Dimitrova; Juan Gea-Banacloche; Seth M Steinberg; Jennifer L Sadler; Stephanie N Hicks; Ellen Carroll; Jennifer S Wilder; Mark Parta; Lauren Skeffington; Thomas E Hughes; Jenny E Blau; Miranda M Broadney; Jeremy J Rose; Amy P Hsu; Rochelle Fletcher; Natalia S Nunes; Xiao-Yi Yan; William G Telford; Veena Kapoor; Jeffrey I Cohen; Alexandra F Freeman; Elizabeth Garabedian; Steven M Holland; Andrea Lisco; Harry L Malech; Luigi D Notarangelo; Irini Sereti; Nirali N Shah; Gulbu Uzel; Christa S Zerbe; Daniel H Fowler; Ronald E Gress; Christopher G Kanakry; Jennifer A Kanakry Journal: Biol Blood Marrow Transplant Date: 2019-09-04 Impact factor: 5.742
Authors: Tyler Harkness; Xiaoqing Fu; Yuqing Zhang; Hyon K Choi; John H Stone; Kimberly G Blumenthal; Zachary S Wallace Journal: Ann Allergy Asthma Immunol Date: 2020-03-27 Impact factor: 6.347