Quetzal A Class1, Martin E Rickert1, Henrik Larsson1, Paul Lichtenstein1, Brian M D'Onofrio1. 1. Quetzal A. Class, BS, Martin E. Rickert, PhD, Department of Psychological and Brain Sciences, Indiana University, Bloomington, Indiana; Henrik Larsson, PhD, Paul Lichtenstein, PhD, Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Brian M. D'Onofrio, PhD, Department of Psychological and Brain Sciences, Indiana University, Bloomington, Indiana.
Abstract
BACKGROUND: It is unclear whether associations between fetal growth and psychiatric and socioeconomic problems are consistent with causal mechanisms. AIMS: To estimate the extent to which associations are a result of unmeasured confounding factors using a sibling-comparison approach. METHOD: We predicted outcomes from continuously measured birth weight in a Swedish population cohort (n = 3 291 773), while controlling for measured and unmeasured confounding. RESULTS: In the population, lower birth weight (⩽ 2500 g) increased the risk of all outcomes. Sibling-comparison models indicated that lower birth weight independently predicted increased risk for autism spectrum disorder (hazard ratio for low birth weight = 2.44, 95% CI 1.99-2.97) and attention-deficit hyperactivity disorder. Although attenuated, associations remained for psychotic or bipolar disorder and educational problems. Associations with suicide attempt, substance use problems and social welfare receipt, however, were fully attenuated in sibling comparisons. CONCLUSIONS: Results suggest that fetal growth, and factors that influence it, contribute to psychiatric and socioeconomic problems. Royal College of Psychiatrists.
BACKGROUND: It is unclear whether associations between fetal growth and psychiatric and socioeconomic problems are consistent with causal mechanisms. AIMS: To estimate the extent to which associations are a result of unmeasured confounding factors using a sibling-comparison approach. METHOD: We predicted outcomes from continuously measured birth weight in a Swedish population cohort (n = 3 291 773), while controlling for measured and unmeasured confounding. RESULTS: In the population, lower birth weight (⩽ 2500 g) increased the risk of all outcomes. Sibling-comparison models indicated that lower birth weight independently predicted increased risk for autism spectrum disorder (hazard ratio for low birth weight = 2.44, 95% CI 1.99-2.97) and attention-deficit hyperactivity disorder. Although attenuated, associations remained for psychotic or bipolar disorder and educational problems. Associations with suicide attempt, substance use problems and social welfare receipt, however, were fully attenuated in sibling comparisons. CONCLUSIONS: Results suggest that fetal growth, and factors that influence it, contribute to psychiatric and socioeconomic problems. Royal College of Psychiatrists.
Authors: Maria M Groen-Blokhuis; Christel M Middeldorp; Catharina E M van Beijsterveldt; Dorret I Boomsma Journal: J Am Acad Child Adolesc Psychiatry Date: 2011-10-22 Impact factor: 8.829
Authors: Kristine B Walhovd; Anders M Fjell; Timothy T Brown; Joshua M Kuperman; Yoonho Chung; Donald J Hagler; J Cooper Roddey; Matthew Erhart; Connor McCabe; Natacha Akshoomoff; David G Amaral; Cinnamon S Bloss; Ondrej Libiger; Nicholas J Schork; Burcu F Darst; B J Casey; Linda Chang; Thomas M Ernst; Jean Frazier; Jeffrey R Gruen; Walter E Kaufmann; Sarah S Murray; Peter van Zijl; Stewart Mostofsky; Anders M Dale Journal: Proc Natl Acad Sci U S A Date: 2012-11-19 Impact factor: 11.205
Authors: Maureen Hack; Hudson G Taylor; Mark Schluchter; Laura Andreias; Dennis Drotar; Nancy Klein Journal: J Dev Behav Pediatr Date: 2009-04 Impact factor: 2.225
Authors: Paul Lichtenstein; Benjamin H Yip; Camilla Björk; Yudi Pawitan; Tyrone D Cannon; Patrick F Sullivan; Christina M Hultman Journal: Lancet Date: 2009-01-17 Impact factor: 79.321
Authors: Quetzal A Class; Preben B Mortensen; Tine B Henriksen; Christina Dalman; Brian M DʼOnofrio; Ali S Khashan Journal: Psychosom Med Date: 2015-10 Impact factor: 4.312
Authors: Ayesha C Sujan; Martin E Rickert; Quetzal A Class; Claire A Coyne; Paul Lichtenstein; Catarina Almqvist; Henrik Larsson; Arvid Sjölander; Benjamin B Lahey; Carol van Hulle; Irwin Waldman; A Sara Öberg; Brian M D'Onofrio Journal: Behav Genet Date: 2015-09-24 Impact factor: 2.805
Authors: Allison M Momany; Jaclyn M Kamradt; Josie M Ullsperger; Alexis L Elmore; Joel T Nigg; Molly A Nikolas Journal: J Abnorm Psychol Date: 2016-11-17
Authors: Erik Pettersson; Henrik Larsson; Brian D'Onofrio; Catarina Almqvist; Paul Lichtenstein Journal: JAMA Psychiatry Date: 2019-05-01 Impact factor: 21.596
Authors: Mark J Taylor; Mina A Rosenqvist; Henrik Larsson; Christopher Gillberg; Brian M D'Onofrio; Paul Lichtenstein; Sebastian Lundström Journal: JAMA Psychiatry Date: 2020-09-01 Impact factor: 21.596