Jan C Beucke1, Jorge Sepulcre1, Mark C Eldaief1, Miriam Sebold1, Norbert Kathmann1, Christian Kaufmann1. 1. Jan C. Beucke, MS, Department of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany and Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, Massachusetts, USA; Jorge Sepulcre, MD, PhD, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston and Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, Massachusetts, USA; Mark C. Eldaief, MD, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA; Miriam Sebold, MS, Department of Psychology, Humboldt-Universität zu Berlin and Emotional Neuroscience Group, Charité Universitätsmedizin Berlin, Berlin, Germany; Norbert Kathmann, PhD, Department of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany; Christian Kaufmann, MS, Department of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany.
Abstract
BACKGROUND: Although neurobiological models of obsessive-compulsive disorder (OCD) traditionally emphasise the central role of corticostriatal brain regions, studies of default mode network integrity have garnered increasing interest, but have produced conflicting results. AIMS: To resolve these discrepant findings by examining the integrity of default mode network subsystems in OCD. METHOD: Comparison of seed-based resting-state functional connectivity of 11 default mode network components between 46 patients with OCD and 46 controls using functional magnetic resonance imaging. RESULTS: Significantly reduced connectivity within the dorsal medial prefrontal cortex self subsystem was identified in the OCD group, and remained significant after controlling for medication status and life-time history of affective disorders. Further, greater connectivity between the self subsystem and salience and attention networks was observed. CONCLUSIONS: Results indicate that people with OCD show abnormalities in a neural system previously associated with self-referential processing in healthy individuals, and suggest the need for examination of dynamic interactions between this default mode network subsystem and other large-scale networks in this disorder. Royal College of Psychiatrists.
BACKGROUND: Although neurobiological models of obsessive-compulsive disorder (OCD) traditionally emphasise the central role of corticostriatal brain regions, studies of default mode network integrity have garnered increasing interest, but have produced conflicting results. AIMS: To resolve these discrepant findings by examining the integrity of default mode network subsystems in OCD. METHOD: Comparison of seed-based resting-state functional connectivity of 11 default mode network components between 46 patients with OCD and 46 controls using functional magnetic resonance imaging. RESULTS: Significantly reduced connectivity within the dorsal medial prefrontal cortex self subsystem was identified in the OCD group, and remained significant after controlling for medication status and life-time history of affective disorders. Further, greater connectivity between the self subsystem and salience and attention networks was observed. CONCLUSIONS: Results indicate that people with OCD show abnormalities in a neural system previously associated with self-referential processing in healthy individuals, and suggest the need for examination of dynamic interactions between this default mode network subsystem and other large-scale networks in this disorder. Royal College of Psychiatrists.
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