Massimiliano de Zambotti1, Ian M Colrain2, Harold S Javitz1, Fiona C Baker3. 1. Center for Health Sciences, SRI International, Menlo Park, California. 2. Center for Health Sciences, SRI International, Menlo Park, California; Melbourne School of Psychological Sciences, University of Melbourne, Parkville, Victoria, Australia. 3. Center for Health Sciences, SRI International, Menlo Park, California; Brain Function Research Group, School of Physiology, University of the Witwatersrand, Johannesburg, South Africa. Electronic address: fiona.baker@sri.com.
Abstract
OBJECTIVE: To quantify the impact of objectively recorded hot flashes on objective sleep in perimenopausal women. DESIGN: Cross-sectional study. Participants underwent 1-5 laboratory-based polysomnographic recordings for a total of 63 nights, including sternal skin-conductance measures, from which 222 hot flashes were identified according to established criteria. Data were analyzed with hierarchical mixed-effect models and Spearman's rank correlations. SETTING: Sleep laboratory. PATIENT(S): Thirty-four perimenopausal women (age ± SD: 50.4 ± 2.7 years). INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Perceived and polysomnographic sleep measures (sleep quality, amount of time spent awake after sleep onset, and number of awakenings). Subjective (frequency and level of bother) and objective (frequency and amount of hot flash-associated awake time) hot-flash measures. RESULT(S): Women had an average of 3.5 (95% confidence interval: 2.8-4.2, range = 1-9) objective hot flashes per night. A total of 69.4% of hot flashes were associated with an awakening. Hot flash-associated time awake per night was, on average, 16.6 minutes (95% confidence interval: 10.8-22.4 minutes), which accounted for 27.2% (SD 27.1) of total awake time per night. Hot flash-associated time awake, but not hot flash frequency, was negatively associated with sleep efficiency and positively associated with waking after sleep onset. In addition, self-reported wakefulness correlated with hot flash-associated waking, suggesting that women's estimates of wakefulness are influenced by the amount of time spent awake in association with hot flashes during the night. Having more perceived and bothersome hot flashes was correlated with more perceived wakefulness and awakenings and more objective hot flash-associated time awake and hot-flash frequency. CONCLUSION(S): The presence of physiological hot flashes accounts for a significant proportion of total objective time awake during the night in perimenopausal women.
OBJECTIVE: To quantify the impact of objectively recorded hot flashes on objective sleep in perimenopausal women. DESIGN: Cross-sectional study. Participants underwent 1-5 laboratory-based polysomnographic recordings for a total of 63 nights, including sternal skin-conductance measures, from which 222 hot flashes were identified according to established criteria. Data were analyzed with hierarchical mixed-effect models and Spearman's rank correlations. SETTING: Sleep laboratory. PATIENT(S): Thirty-four perimenopausal women (age ± SD: 50.4 ± 2.7 years). INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Perceived and polysomnographic sleep measures (sleep quality, amount of time spent awake after sleep onset, and number of awakenings). Subjective (frequency and level of bother) and objective (frequency and amount of hot flash-associated awake time) hot-flash measures. RESULT(S): Women had an average of 3.5 (95% confidence interval: 2.8-4.2, range = 1-9) objective hot flashes per night. A total of 69.4% of hot flashes were associated with an awakening. Hot flash-associated time awake per night was, on average, 16.6 minutes (95% confidence interval: 10.8-22.4 minutes), which accounted for 27.2% (SD 27.1) of total awake time per night. Hot flash-associated time awake, but not hot flash frequency, was negatively associated with sleep efficiency and positively associated with waking after sleep onset. In addition, self-reported wakefulness correlated with hot flash-associated waking, suggesting that women's estimates of wakefulness are influenced by the amount of time spent awake in association with hot flashes during the night. Having more perceived and bothersome hot flashes was correlated with more perceived wakefulness and awakenings and more objective hot flash-associated time awake and hot-flash frequency. CONCLUSION(S): The presence of physiological hot flashes accounts for a significant proportion of total objective time awake during the night in perimenopausal women.
Authors: Fiona C Baker; Stephanie A Sassoon; Tracey Kahan; Latha Palaniappan; Christian L Nicholas; John Trinder; Ian M Colrain Journal: J Sleep Res Date: 2012-03-14 Impact factor: 3.981
Authors: Hadine Joffe; David P White; Sybil L Crawford; Kristin E McCurnin; Nicole Economou; Stephanie Connors; Janet E Hall Journal: Menopause Date: 2013-09 Impact factor: 2.953
Authors: Howard M Kravitz; Patricia A Ganz; Joyce Bromberger; Lynda H Powell; Kim Sutton-Tyrrell; Peter M Meyer Journal: Menopause Date: 2003 Jan-Feb Impact factor: 2.953
Authors: Massimiliano de Zambotti; Ian M Colrain; Stephanie A Sassoon; Christian L Nicholas; John Trinder; Fiona C Baker Journal: Menopause Date: 2013-11 Impact factor: 2.953
Authors: Nicole J Gervais; Luke Remage-Healey; Joseph R Starrett; Daniel J Pollak; Jessica A Mong; Agnès Lacreuse Journal: J Neurosci Date: 2018-12-26 Impact factor: 6.167
Authors: Fiona C Baker; Adrian R Willoughby; Stephanie A Sassoon; Ian M Colrain; Massimiliano de Zambotti Journal: Psychoneuroendocrinology Date: 2015-06-17 Impact factor: 4.905