STUDY OBJECTIVE: To assess the importance of the menstrual pattern as a marker for clinical and laboratory alterations related to metabolic syndrome (MS) and polycystic ovary syndrome (PCOS) among Brazilian adolescents. DESIGN: A cross-sectional study. SETTING: Endocrine Gynecology Outpatient Clinic of the Adolescent Health Studies Center (NESA) at the Pedro Ernesto University Hospital. PARTICIPANTS: 59 girls (12-19 years old) were classified by their menstrual cycles as regular (n = 23) and irregular (n = 36). INTERVENTION: None. MAIN OUTCOME MEASURES: Biochemical collections were made of peripheral blood after fasting for 12 hours, and the oral glucose tolerance test with 75 g of anhydrous glucose. RESULTS: PCOS, MS, and the criteria for MS were significantly more frequent (P < .05) in the subgroup with irregular menstruation. Adolescents with irregular cycles presented a significant increase in waist circumference, glycemia 2 hours after oral glucose overload (2 h), fasting and 2-h insulin, HOMA-IR, and triglycerides. In contrast, the glucose/insulin ratio, quantitative insulin-sensitivity check index, and HDL serum levels were significantly lower among patients with irregular menstruation, compared to those with regular cycles. In the logistic regression, we noted that insulin 2 h ≥ 75 μIU/mL (r = 1.90; P = .018), waist circumference > 95 cm (r = 2.21; P = .006) and diagnosis of PCOS (r = 1.93; P = .023) were significantly correlated to irregular cycles. CONCLUSIONS: We concluded that close observation of menstrual cycle patterns is an important tool for identifying adolescents at higher risk of developing PCOS and MS.
STUDY OBJECTIVE: To assess the importance of the menstrual pattern as a marker for clinical and laboratory alterations related to metabolic syndrome (MS) and polycystic ovary syndrome (PCOS) among Brazilian adolescents. DESIGN: A cross-sectional study. SETTING: Endocrine Gynecology Outpatient Clinic of the Adolescent Health Studies Center (NESA) at the Pedro Ernesto University Hospital. PARTICIPANTS: 59 girls (12-19 years old) were classified by their menstrual cycles as regular (n = 23) and irregular (n = 36). INTERVENTION: None. MAIN OUTCOME MEASURES: Biochemical collections were made of peripheral blood after fasting for 12 hours, and the oral glucose tolerance test with 75 g of anhydrous glucose. RESULTS:PCOS, MS, and the criteria for MS were significantly more frequent (P < .05) in the subgroup with irregular menstruation. Adolescents with irregular cycles presented a significant increase in waist circumference, glycemia 2 hours after oral glucose overload (2 h), fasting and 2-h insulin, HOMA-IR, and triglycerides. In contrast, the glucose/insulin ratio, quantitative insulin-sensitivity check index, and HDL serum levels were significantly lower among patients with irregular menstruation, compared to those with regular cycles. In the logistic regression, we noted that insulin 2 h ≥ 75 μIU/mL (r = 1.90; P = .018), waist circumference > 95 cm (r = 2.21; P = .006) and diagnosis of PCOS (r = 1.93; P = .023) were significantly correlated to irregular cycles. CONCLUSIONS: We concluded that close observation of menstrual cycle patterns is an important tool for identifying adolescents at higher risk of developing PCOS and MS.
Authors: Michelle L Meyer; Daniela Sotres-Alvarez; Anne Z Steiner; Larry Cousins; Gregory A Talavera; Jianwen Cai; Martha L Daviglus; Laura R Loehr Journal: J Clin Endocrinol Metab Date: 2020-03-01 Impact factor: 5.958
Authors: Havagiray R Chitme; Eman A K Al Azawi; Anfal M Al Abri; Buthina M Al Busaidi; Zamzam K A Salam; Maisa M Al Taie; Saja K Al Harbo Journal: J Taibah Univ Med Sci Date: 2017-01-13
Authors: Sang Su Lee; Do Hoon Kim; Ga-Eun Nam; Hyo-Yun Nam; Young Eun Kim; Sung Ho Lee; Kyung Do Han; Yong Gyu Park Journal: Korean J Fam Med Date: 2016-01-27