Chengfu Xu1, Ming Yan, Yan Sun, Jungsoo Joo, Xingyong Wan, Chaohui Yu, Qunyan Wang, Chao Shen, Peng Chen, Youming Li, William G Coleman. 1. Department of Gastroenterology, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China; Cancer Cluster, National Institute on Minority Health and Health Disparities, National Institutes of Health, Bethesda, MD, USA; Laboratory of Biochemistry and Genetics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
Abstract
BACKGROUND: Helicobacter pylori infection is highly prevalent worldwide. The association between obesity and H. pylori infection is controversial in the literature. This study aims to investigate the prevalence of H. pylori infection and its relation with body mass index (BMI) in a Chinese population. MATERIALS AND METHODS: A cross-sectional study was performed among adults who underwent health checkups at the First Affiliated Hospital, College of Medicine, Zhejiang University in 2013. The prevalence of H. pylori infection was examined by (13)C urea breath tests, and the association between prevalence of H. pylori infection and BMI was analyzed. RESULTS: Of the 8820 participants enrolled, 3859 (43.8%) were positive for H. pylori infection. H. pylori-positive participants had a more unfavorable metabolic profile than H. pylori-negative participants. Overweight/obese participants showed a higher prevalence of H. pylori infection than that of lean participants, and a positive linear correlation between BMI and prevalence of H. pylori infection was observed. Both unadjusted and adjusted analysis revealed that BMI was significantly associated with risk factors of H. pylori infection. CONCLUSIONS: Our results showed that BMI was significantly and positively associated with H. pylori infection, and a high BMI was associated with an increased risk of the infection.
BACKGROUND:Helicobacter pylori infection is highly prevalent worldwide. The association between obesity and H. pylori infection is controversial in the literature. This study aims to investigate the prevalence of H. pylori infection and its relation with body mass index (BMI) in a Chinese population. MATERIALS AND METHODS: A cross-sectional study was performed among adults who underwent health checkups at the First Affiliated Hospital, College of Medicine, Zhejiang University in 2013. The prevalence of H. pylori infection was examined by (13)C urea breath tests, and the association between prevalence of H. pylori infection and BMI was analyzed. RESULTS: Of the 8820 participants enrolled, 3859 (43.8%) were positive for H. pylori infection. H. pylori-positive participants had a more unfavorable metabolic profile than H. pylori-negative participants. Overweight/obeseparticipants showed a higher prevalence of H. pylori infection than that of lean participants, and a positive linear correlation between BMI and prevalence of H. pylori infection was observed. Both unadjusted and adjusted analysis revealed that BMI was significantly associated with risk factors of H. pylori infection. CONCLUSIONS: Our results showed that BMI was significantly and positively associated with H. pylori infection, and a high BMI was associated with an increased risk of the infection.
Authors: Jieun Jang; Tianyi Wang; Hui Cai; Fei Ye; Gwen Murphy; Taichi Shimazu; Philip R Taylor; You-Lin Qiao; Keun-Young Yoo; Sun Ha Jee; Jeongseon Kim; Sheau-Chiann Chen; Christian C Abnet; Shoichiro Tsugane; Wei Zheng; Xiao-Ou Shu; Michael Pawlita; Sue K Park; Meira Epplein Journal: Int J Cancer Date: 2019-12-12 Impact factor: 7.396
Authors: Shantanu Solanki; Raja Chandra Chakinala; Khwaja Fahad Haq; Muhammad Ali Khan; Alina Kifayat; Katherine Linder; Zubair Khan; Uvesh Mansuri; Khwaja Saad Haq; Christopher Nabors; Wilbert S Aronow Journal: Ann Transl Med Date: 2019-12