BACKGROUND/ OBJECTIVES: The risk of chronic kidney disease (CKD) in patients who regularly drink soda is controversial. The objective of this meta-analysis was to evaluate the associations between consumption of sugar-sweetened and artificially sweetened soda and CKD. METHODS: A literature search was performed using MEDLINE, EMBASE and the Cochrane Database of Systematic Reviews from inception until 30 June 2014. Studies that reported odds ratios or hazard ratios comparing the risk of CKD in patients consuming significant amounts of either sugar-sweetened or artificially sweetened soda versus those who did not consume soda were included. Pooled risk ratios (RR) and 95% confidence intervals (CI) were calculated using a random-effects, generic inverse variance method. RESULTS: Five studies were included in our analysis of the association between consumption of sugar-sweetened soda and CKD. The pooled RR of CKD in patients consuming sugar-sweetened soda was 1.58 (95% CI 1.00-2.49). Four studies were selected to assess the association between consumption of artificially sweetened soda and CKD. The pooled RR of CKD in patients consuming artificially sweetened soda was 1.33 (95% CI 0.82-2.15). CONCLUSIONS: Our study demonstrates statistically significant increased risks of CKD in patients consuming sugar-sweetened soda, but not in patients consuming artificially sweetened soda. This finding suggests that sugar-sweetened soda consumption is associated with CKD and may impact clinical management and primary prevention of CKD in high-risk patients.
BACKGROUND/ OBJECTIVES: The risk of chronic kidney disease (CKD) in patients who regularly drink soda is controversial. The objective of this meta-analysis was to evaluate the associations between consumption of sugar-sweetened and artificially sweetened soda and CKD. METHODS: A literature search was performed using MEDLINE, EMBASE and the Cochrane Database of Systematic Reviews from inception until 30 June 2014. Studies that reported odds ratios or hazard ratios comparing the risk of CKD in patients consuming significant amounts of either sugar-sweetened or artificially sweetened soda versus those who did not consume soda were included. Pooled risk ratios (RR) and 95% confidence intervals (CI) were calculated using a random-effects, generic inverse variance method. RESULTS: Five studies were included in our analysis of the association between consumption of sugar-sweetened soda and CKD. The pooled RR of CKD in patients consuming sugar-sweetened soda was 1.58 (95% CI 1.00-2.49). Four studies were selected to assess the association between consumption of artificially sweetened soda and CKD. The pooled RR of CKD in patients consuming artificially sweetened soda was 1.33 (95% CI 0.82-2.15). CONCLUSIONS: Our study demonstrates statistically significant increased risks of CKD in patients consuming sugar-sweetened soda, but not in patients consuming artificially sweetened soda. This finding suggests that sugar-sweetened soda consumption is associated with CKD and may impact clinical management and primary prevention of CKD in high-risk patients.
Authors: Fernando E García-Arroyo; Magdalena Cristóbal; Abraham S Arellano-Buendía; Horacio Osorio; Edilia Tapia; Virgilia Soto; Magdalena Madero; Miguel A Lanaspa; Carlos Roncal-Jiménez; Lise Bankir; Richard J Johnson; Laura-Gabriela Sánchez-Lozada Journal: Am J Physiol Regul Integr Comp Physiol Date: 2016-04-06 Impact factor: 3.619
Authors: Laura G Sánchez-Lozada; Carlos A Roncal-Jimenez; Fernando E García-Arroyo; Thomas Jensen; Miguel A Lanaspa; Richard J Johnson Journal: Am J Physiol Regul Integr Comp Physiol Date: 2019-01-23 Impact factor: 3.619
Authors: C Thongprayoon; W Cheungpasitporn; P Phatharacharukul; P J Edmonds; Q Kaewpoowat; P Mahaparn; J Bruminhent; S B Erickson Journal: Int J Clin Pract Date: 2015-07-05 Impact factor: 2.503
Authors: Christopher L Chapman; Tigran Grigoryan; Nicole T Vargas; Emma L Reed; Paul J Kueck; Leonard D Pietrafesa; Adam C Bloomfield; Blair D Johnson; Zachary J Schlader Journal: Am J Physiol Renal Physiol Date: 2020-03-16
Authors: Raymond Vanholder; Steven Van Laecke; Griet Glorieux; Francis Verbeke; Esmeralda Castillo-Rodriguez; Alberto Ortiz Journal: Toxins (Basel) Date: 2018-06-12 Impact factor: 4.546