Literature DB >> 27135048

Not-so-healthy sugar substitutes?

Susan E Swithers1.   

Abstract

Replacing sugar-sweetened beverages with diet soft drinks containing sugar substitutes that provide few or no calories has been suggested as one strategy for promoting improved public health outcomes. However, current scientific evidence indicates that routine consumption of beverages with non-nutritive sweeteners not only fails to prevent disease, but is associated with increases in risks for the same health outcomes associated with sugar-sweetened beverages, including type 2 diabetes, cardiovascular disease, hypertension and stroke. Results from pre-clinical studies have provided plausible biological mechanisms that could promote these counterintuitive negative health effects of artificial sweeteners. Taken together, scientific studies currently indicate that public health will be improved by reducing intake of all sweeteners, both caloric and non-caloric.

Entities:  

Year:  2016        PMID: 27135048      PMCID: PMC4846275          DOI: 10.1016/j.cobeha.2016.03.003

Source DB:  PubMed          Journal:  Curr Opin Behav Sci        ISSN: 2352-1546


  43 in total

1.  Sweet taste of saccharin induces weight gain without increasing caloric intake, not related to insulin-resistance in Wistar rats.

Authors:  Kelly Carraro Foletto; Bruna Aparecida Melo Batista; Alice Magagnin Neves; Fernanda de Matos Feijó; Cíntia Reis Ballard; Maria Flávia Marques Ribeiro; Marcello Casaccia Bertoluci
Journal:  Appetite       Date:  2015-11-07       Impact factor: 3.868

2.  Sugar-sweetened beverage and diet soda consumption and the 7-year risk for type 2 diabetes mellitus in middle-aged Japanese men.

Authors:  M Sakurai; K Nakamura; K Miura; T Takamura; K Yoshita; S Y Nagasawa; Y Morikawa; M Ishizaki; T Kido; Y Naruse; Y Suwazono; S Sasaki; H Nakagawa
Journal:  Eur J Nutr       Date:  2014-06       Impact factor: 5.614

3.  Artificial sweeteners induce glucose intolerance by altering the gut microbiota.

Authors:  Jotham Suez; Tal Korem; David Zeevi; Gili Zilberman-Schapira; Christoph A Thaiss; Ori Maza; David Israeli; Niv Zmora; Shlomit Gilad; Adina Weinberger; Yael Kuperman; Alon Harmelin; Ilana Kolodkin-Gal; Hagit Shapiro; Zamir Halpern; Eran Segal; Eran Elinav
Journal:  Nature       Date:  2014-09-17       Impact factor: 49.962

4.  Estimated Global, Regional, and National Disease Burdens Related to Sugar-Sweetened Beverage Consumption in 2010.

Authors:  Gitanjali M Singh; Renata Micha; Shahab Khatibzadeh; Stephen Lim; Majid Ezzati; Dariush Mozaffarian
Journal:  Circulation       Date:  2015-06-29       Impact factor: 29.690

5.  Artificial sweeteners produce the counterintuitive effect of inducing metabolic derangements.

Authors:  Susan E Swithers
Journal:  Trends Endocrinol Metab       Date:  2013-07-10       Impact factor: 12.015

6.  Adverse effects of high-intensity sweeteners on energy intake and weight control in male and obesity-prone female rats.

Authors:  Susan E Swithers; Camille H Sample; Terry L Davidson
Journal:  Behav Neurosci       Date:  2013-02-11       Impact factor: 1.912

7.  Experience with the high-intensity sweetener saccharin impairs glucose homeostasis and GLP-1 release in rats.

Authors:  Susan E Swithers; Alycia F Laboy; Kiely Clark; Stephanie Cooper; T L Davidson
Journal:  Behav Brain Res       Date:  2012-04-26       Impact factor: 3.332

8.  Temporal Trends in Mortality in the United States, 1969-2013.

Authors:  Jiemin Ma; Elizabeth M Ward; Rebecca L Siegel; Ahmedin Jemal
Journal:  JAMA       Date:  2015-10-27       Impact factor: 56.272

9.  Saccharin and aspartame, compared with sucrose, induce greater weight gain in adult Wistar rats, at similar total caloric intake levels.

Authors:  Fernanda de Matos Feijó; Cíntia Reis Ballard; Kelly Carraro Foletto; Bruna Aparecida Melo Batista; Alice Magagnin Neves; Maria Flávia Marques Ribeiro; Marcello Casaccia Bertoluci
Journal:  Appetite       Date:  2012-10-23       Impact factor: 3.868

10.  Changes in water and beverage intake and long-term weight changes: results from three prospective cohort studies.

Authors:  A Pan; V S Malik; T Hao; W C Willett; D Mozaffarian; F B Hu
Journal:  Int J Obes (Lond)       Date:  2013-01-15       Impact factor: 5.095

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  10 in total

1.  Perspective: Standards for Research and Reporting on Low-Energy ("Artificial") Sweeteners.

Authors:  David J Mela; John McLaughlin; Peter J Rogers
Journal:  Adv Nutr       Date:  2020-05-01       Impact factor: 8.701

2.  Effects of nucleus accumbens insulin inactivation on microstructure of licking for glucose and saccharin in male and female rats.

Authors:  Kenneth D Carr; Sydney P Weiner
Journal:  Physiol Behav       Date:  2022-03-02

Review 3.  Artificial sweeteners and metabolic dysregulation: Lessons learned from agriculture and the laboratory.

Authors:  Jane Shearer; Susan E Swithers
Journal:  Rev Endocr Metab Disord       Date:  2016-06       Impact factor: 6.514

4.  Sugar beet powder production using different drying methods, characterization and influence on sensory quality of cocoa-hazelnut cream.

Authors:  Ertan Ermis; Merve Özkan
Journal:  J Food Sci Technol       Date:  2020-08-17       Impact factor: 3.117

5.  Intermittent, extended access to preferred food leads to escalated food reinforcement and cyclic whole-body metabolism in rats: Sex differences and individual vulnerability.

Authors:  Samantha R Spierling; Alison D Kreisler; Casey A Williams; Savannah Y Fang; Sarah N Pucci; Kelsey T Kines; Eric P Zorrilla
Journal:  Physiol Behav       Date:  2018-04-11

Review 6.  Hypotheses and evidence related to intense sweeteners and effects on appetite and body weight changes: A scoping review of reviews.

Authors:  Annhild Mosdøl; Gunn Elisabeth Vist; Camilla Svendsen; Hubert Dirven; Inger Therese Laugsand Lillegaard; Gro Haarklou Mathisen; Trine Husøy
Journal:  PLoS One       Date:  2018-07-18       Impact factor: 3.240

7.  Exposure to liquid sweetness in early childhood: artificially-sweetened and sugar-sweetened beverage consumption at 4-5 years and risk of overweight and obesity at 7-8 years.

Authors:  A K Macintyre; L Marryat; S Chambers
Journal:  Pediatr Obes       Date:  2018-04-06       Impact factor: 4.000

8.  Measuring Artificial Sweeteners Toxicity Using a Bioluminescent Bacterial Panel.

Authors:  Dorin Harpaz; Loo Pin Yeo; Francesca Cecchini; Trish H P Koon; Ariel Kushmaro; Alfred I Y Tok; Robert S Marks; Evgeni Eltzov
Journal:  Molecules       Date:  2018-09-25       Impact factor: 4.411

Review 9.  Sugar Substitutes: Mechanism, Availability, Current Use and Safety Concerns-An Update.

Authors:  Megha Gupta
Journal:  Open Access Maced J Med Sci       Date:  2018-10-19

Review 10.  Low-energy sweeteners and body weight: a citation network analysis.

Authors:  Mie Normand; Christian Ritz; David Mela; Anne Raben
Journal:  BMJ Nutr Prev Health       Date:  2021-04-01
  10 in total

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