| Literature DB >> 25250105 |
Kazem Anvari1, Azar Fanipakdel1, Yasmin Davoudi2.
Abstract
BACKGROUND: The beginning of metastasis poorly affects the prognosis of breastcancer patients. Lung is the most frequent site of visceral metastasis, and the rate of recurrence is 10-30%. We have tried to find out if the routine Chest X Ray (CXR) could play a role for early detection of lung metastasis, during the prognosis of these patients.Entities:
Keywords: Breast cancer; Lung metastas; Surveillance
Year: 2013 PMID: 25250105 PMCID: PMC4142908
Source DB: PubMed Journal: Iran J Cancer Prev ISSN: 2008-2398
Patients and tumors characteristics
| Variable | Number | Frequency (%) |
|---|---|---|
| Menstruation status | ||
| Premenopausal | 29 | 52 |
| Primary m. | 12 | 21 |
| Post m. | 15 | 27 |
|
| ||
| Surgery type | ||
| Biopsy | 4 | 7.1 |
| Lumpectomy | 1 | 1.8 |
| Simple mastectomy | 4 | 7.1 |
| MRM | 47 | 83.9 |
|
| ||
| Grade | ||
| Low | 1 | 1.8 |
| Intermediate | 17 | 30.4 |
| High | 5 | 8.9 |
| Missing | 33 | 58.9 |
|
| ||
| Other metastasis | ||
| Bone | 15 | 26.8 |
| Liver | 11 | 19.6 |
| Brain | 8 | 14.3 |
|
| ||
| ER (In 32 patients) | ||
| Negative to weak + | 27 | 84.4 |
| Mod to strong + | 5 | 15.6 |
|
| ||
| PR | ||
| Negative to weak + | 29 | 90.6 |
| Mod to strong + | 3 | 9.4 |
|
| ||
| Her2 IHC (In 15) | ||
| Negative to weak + | 8 | 53.3 |
| Mod to strong + | 7 | 46.7 |
|
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| Lung metastasis DX (In 53) | ||
| Routine CXR | 41 | 77.4 |
| Symptom | 12 | 22.6 |
|
| ||
| Lung metastasis response to chemotherapy (In 49) | ||
| Partial Response | 33 | 67.5 |
| Stable Disease | 11 | 22.5 |
| Progression | 5 | 10 |
Figure 1Survival curves for the interval between the time of diagnosis and the occurrence of lung metastasis
Figure 2Distribution of radiologic patterns of pulmonary metastasis in BC patients
Figure 3Metastatic pulmonary nodule in a patient with BC
Figure 4Metastatic pulmonary effusion in a BC patient
Figure 5Survival curves for diagnosis
Figure 6Survival curves for lung metastasis
Figure 7Survival curves of BC patients with PM according to diagnosis way
Probable prognostic factors assessment on PFS in breast cancer patients with lung metastases
| Number | percent | PFS (Median) | P value | |
|---|---|---|---|---|
| Isolated lung mets | 25 | 47.5 | 5.5m | 0.301 |
| With other mets | 28 | 52.5 | 10m | |
| Mets nodules only | 25 | 50 | 8m | 0.914 |
| Pleural effusion with or without nodules | 25 | 50 | 9m | |
| Asymptomatic mets (found via radiology) | 40 | 77.4 | 7m | 0.348 |
| Symptomatic | 12 | 22.6 | 14m | |
| Partial response to chemotherapy | 32 | 67 | 9m | 0.185 |
| Persistent or progressive disease | 16 | 33 | 7m | |
mets: metastatic