Literature DB >> 25248872

Biosecurity and Open-Source Biology: The Promise and Peril of Distributed Synthetic Biological Technologies.

Nicholas G Evans1, Michael J Selgelid.   

Abstract

In this article, we raise ethical concerns about the potential misuse of open-source biology (OSB): biological research and development that progresses through an organisational model of radical openness, deskilling, and innovation. We compare this organisational structure to that of the open-source software model, and detail salient ethical implications of this model. We demonstrate that OSB, in virtue of its commitment to openness, may be resistant to governance attempts.

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Year:  2014        PMID： 25248872     DOI： 10.1007/s11948-014-9591-3

Source DB:  PubMed          Journal:  Sci Eng Ethics        ISSN： 1353-3452            Impact factor:   3.525


  21 in total

1.  Chemical synthesis of poliovirus cDNA: generation of infectious virus in the absence of natural template.

Authors:  Jeronimo Cello; Aniko V Paul; Eckard Wimmer
Journal:  Science       Date:  2002-07-11       Impact factor: 47.728

2.  Garage biotech: Life hackers.

Authors:  Heidi Ledford
Journal:  Nature       Date:  2010-10-07       Impact factor: 49.962

3.  Managing the unimaginable. Regulatory responses to the challenges posed by synthetic biology and synthetic genomics.

Authors:  Gabrielle N Samuel; Michael J Selgelid; Ian Kerridge
Journal:  EMBO Rep       Date:  2008-12-12       Impact factor: 8.807

4.  Pharmaceuticals, political money, and public policy: a theoretical and empirical agenda.

Authors:  Paul D Jorgensen
Journal:  J Law Med Ethics       Date:  2013       Impact factor: 1.718

5.  Great expectations--ethics, avian flu and the value of progress.

Authors:  Nicholas G Evans
Journal:  J Med Ethics       Date:  2012-10-30       Impact factor: 2.903

6.  Characterization of the reconstructed 1918 Spanish influenza pandemic virus.

Authors:  Terrence M Tumpey; Christopher F Basler; Patricia V Aguilar; Hui Zeng; Alicia Solórzano; David E Swayne; Nancy J Cox; Jacqueline M Katz; Jeffery K Taubenberger; Peter Palese; Adolfo García-Sastre
Journal:  Science       Date:  2005-10-07       Impact factor: 47.728

Review 7.  Integrating biological redesign: where synthetic biology came from and where it needs to go.

Authors:  Jeffrey C Way; James J Collins; Jay D Keasling; Pamela A Silver
Journal:  Cell       Date:  2014-03-27       Impact factor: 41.582

8.  Ethical and philosophical consideration of the dual-use dilemma in the biological sciences.

Authors:  Seumas Miller; Michael J Selgelid
Journal:  Sci Eng Ethics       Date:  2007-12-01       Impact factor: 3.525

9.  Ethical alternatives to experiments with novel potential pandemic pathogens.

Authors:  Marc Lipsitch; Alison P Galvani
Journal:  PLoS Med       Date:  2014-05-20       Impact factor: 11.069

10.  Adapting standards: ethical oversight of participant-led health research.

Authors:  Effy Vayena; John Tasioulas
Journal:  PLoS Med       Date:  2013-03-12       Impact factor: 11.069
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  6 in total

1.  The ethics of biosafety considerations in gain-of-function research resulting in the creation of potential pandemic pathogens.

Authors:  Nicholas Greig Evans; Marc Lipsitch; Meira Levinson
Journal:  J Med Ethics       Date:  2015-08-28       Impact factor: 2.903

2.  Dual-use decision making: relational and positional issues.

Authors:  Nicholas G Evans
Journal:  Monash Bioeth Rev       Date:  2014 Sep-Dec

3.  A transatlantic perspective on 20 emerging issues in biological engineering.

Authors:  Bonnie C Wintle; Christian R Boehm; Catherine Rhodes; Jennifer C Molloy; Piers Millett; Laura Adam; Rainer Breitling; Rob Carlson; Rocco Casagrande; Malcolm Dando; Robert Doubleday; Eric Drexler; Brett Edwards; Tom Ellis; Nicholas G Evans; Richard Hammond; Jim Haseloff; Linda Kahl; Todd Kuiken; Benjamin R Lichman; Colette A Matthewman; Johnathan A Napier; Seán S ÓhÉigeartaigh; Nicola J Patron; Edward Perello; Philip Shapira; Joyce Tait; Eriko Takano; William J Sutherland
Journal:  Elife       Date:  2017-11-14       Impact factor: 8.140

4.  Ethical and Philosophical Considerations for Gain-of-Function Policy: The Importance of Alternate Experiments.

Authors:  Nicholas Greig Evans
Journal:  Front Bioeng Biotechnol       Date:  2018-02-08

5.  Building biosecurity for synthetic biology.

Authors:  Benjamin D Trump; S E Galaitsi; Evan Appleton; Diederik A Bleijs; Marie-Valentine Florin; Jimmy D Gollihar; R Alexander Hamilton; Todd Kuiken; Filippa Lentzos; Ruth Mampuys; Myriam Merad; Tatyana Novossiolova; Kenneth Oye; Edward Perkins; Natàlia Garcia-Reyero; Catherine Rhodes; Igor Linkov
Journal:  Mol Syst Biol       Date:  2020-07       Impact factor: 11.429

6.  Should We All be Scientists? Re-thinking Laboratory Research as a Calling.

Authors:  Louise Bezuidenhout; Nathaniel A Warne
Journal:  Sci Eng Ethics       Date:  2017-07-19       Impact factor: 3.525
  6 in total

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