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Literature DB >> 25245168

Slit/Robo pathway: a promising therapeutic target for cancer.

Rishi K Gara¹, Sonam Kumari¹, Aditya Ganju¹, Murali M Yallapu¹, Meena Jaggi², Subhash C Chauhan³.

Abstract

Axon guidance molecules, slit glycoprotein (Slit) and Roundabout receptor (Robo), have implications in the regulation of physiological processes. Recent studies indicate that Slit and Robo also have important roles in tumorigenesis, cancer progression and metastasis. The Slit/Robo pathway can be considered a master regulator for multiple oncogenic signaling pathways. Herein, we provide a comprehensive review on the role of these molecules and their associated signaling pathways in cancer progression and metastasis. Overall, the current available data suggest that the Slit/Robo pathway could be a promising target for development of anticancer drugs.

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Year: 2014 PMID： 25245168 PMCID： PMC4445861 DOI： 10.1016/j.drudis.2014.09.008

Source DB: PubMed Journal: Drug Discov Today ISSN： 1359-6446 Impact factor: 7.851

95 in total

1. Activation of Robo1 signaling of breast cancer cells by Slit2 from stromal fibroblast restrains tumorigenesis via blocking PI3K/Akt/β-catenin pathway.

Authors: Po-Hao Chang; Wendy W Hwang-Verslues; Yi-Cheng Chang; Chun-Chin Chen; Michael Hsiao; Yung-Ming Jeng; King-Jen Chang; Eva Y-H P Lee; Jin-Yuh Shew; Wen-Hwa Lee
Journal: Cancer Res Date: 2012-07-23 Impact factor: 12.701

Review 2. Bone metastases: molecular mechanisms and novel therapeutic interventions.

Authors: Dionysios J Papachristou; Efthimia K Basdra; Athanasios G Papavassiliou
Journal: Med Res Rev Date: 2010-09-03 Impact factor: 12.944

3. SLIT/ROBO1 signaling suppresses mammary branching morphogenesis by limiting basal cell number.

Authors: Hector Macias; Angel Moran; Yazeed Samara; Melissa Moreno; Jennifer E Compton; Gwyndolen Harburg; Phyllis Strickland; Lindsay Hinck
Journal: Dev Cell Date: 2011-06-14 Impact factor: 12.270

4. Slit3 inhibits activator protein 1-mediated migration of malignant melanoma cells.

Authors: Alexandra E Denk; Simone Braig; Thomas Schubert; Anja K Bosserhoff
Journal: Int J Mol Med Date: 2011-07-08 Impact factor: 4.101

5. DCC constrains tumour progression via its dependence receptor activity.

Authors: Marie Castets; Laura Broutier; Yann Molin; Marie Brevet; Guillaume Chazot; Nicolas Gadot; Armelle Paquet; Laetitia Mazelin; Loraine Jarrosson-Wuilleme; Jean-Yves Scoazec; Agnès Bernet; Patrick Mehlen
Journal: Nature Date: 2011-12-11 Impact factor: 49.962

6. Slit-2 facilitates interaction of P-cadherin with Robo-3 and inhibits cell migration in an oral squamous cell carcinoma cell line.

Authors: Karin Bauer; Albert Dowejko; A-K Bosserhoff; T E Reichert; Richard Bauer
Journal: Carcinogenesis Date: 2011-03-31 Impact factor: 4.944

7. Roundabout receptors are critical for foregut separation from the body wall.

Authors: Eric Thomas Domyan; Kelsey Branchfield; Daniel A Gibson; L A Naiche; Mark Lewandoski; Marc Tessier-Lavigne; Le Ma; Xin Sun
Journal: Dev Cell Date: 2013-01-14 Impact factor: 12.270

8. Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes.

Authors: Andrew V Biankin; Nicola Waddell; Karin S Kassahn; Marie-Claude Gingras; Lakshmi B Muthuswamy; Amber L Johns; David K Miller; Peter J Wilson; Ann-Marie Patch; Jianmin Wu; David K Chang; Mark J Cowley; Brooke B Gardiner; Sarah Song; Ivon Harliwong; Senel Idrisoglu; Craig Nourse; Ehsan Nourbakhsh; Suzanne Manning; Shivangi Wani; Milena Gongora; Marina Pajic; Christopher J Scarlett; Anthony J Gill; Andreia V Pinho; Ilse Rooman; Matthew Anderson; Oliver Holmes; Conrad Leonard; Darrin Taylor; Scott Wood; Qinying Xu; Katia Nones; J Lynn Fink; Angelika Christ; Tim Bruxner; Nicole Cloonan; Gabriel Kolle; Felicity Newell; Mark Pinese; R Scott Mead; Jeremy L Humphris; Warren Kaplan; Marc D Jones; Emily K Colvin; Adnan M Nagrial; Emily S Humphrey; Angela Chou; Venessa T Chin; Lorraine A Chantrill; Amanda Mawson; Jaswinder S Samra; James G Kench; Jessica A Lovell; Roger J Daly; Neil D Merrett; Christopher Toon; Krishna Epari; Nam Q Nguyen; Andrew Barbour; Nikolajs Zeps; Nipun Kakkar; Fengmei Zhao; Yuan Qing Wu; Min Wang; Donna M Muzny; William E Fisher; F Charles Brunicardi; Sally E Hodges; Jeffrey G Reid; Jennifer Drummond; Kyle Chang; Yi Han; Lora R Lewis; Huyen Dinh; Christian J Buhay; Timothy Beck; Lee Timms; Michelle Sam; Kimberly Begley; Andrew Brown; Deepa Pai; Ami Panchal; Nicholas Buchner; Richard De Borja; Robert E Denroche; Christina K Yung; Stefano Serra; Nicole Onetto; Debabrata Mukhopadhyay; Ming-Sound Tsao; Patricia A Shaw; Gloria M Petersen; Steven Gallinger; Ralph H Hruban; Anirban Maitra; Christine A Iacobuzio-Donahue; Richard D Schulick; Christopher L Wolfgang; Richard A Morgan; Rita T Lawlor; Paola Capelli; Vincenzo Corbo; Maria Scardoni; Giampaolo Tortora; Margaret A Tempero; Karen M Mann; Nancy A Jenkins; Pedro A Perez-Mancera; David J Adams; David A Largaespada; Lodewyk F A Wessels; Alistair G Rust; Lincoln D Stein; David A Tuveson; Neal G Copeland; Elizabeth A Musgrove; Aldo Scarpa; James R Eshleman; Thomas J Hudson; Robert L Sutherland; David A Wheeler; John V Pearson; John D McPherson; Richard A Gibbs; Sean M Grimmond
Journal: Nature Date: 2012-10-24 Impact factor: 49.962

Review 9. Targeting the metabolic microenvironment of tumors.

Authors: Kate M Bailey; Jonathan W Wojtkowiak; Arig Ibrahim Hashim; Robert J Gillies
Journal: Adv Pharmacol Date: 2012

10. Glucocorticoid regulation of SLIT/ROBO tumour suppressor genes in the ovarian surface epithelium and ovarian cancer cells.

Authors: Rachel E Dickinson; K Scott Fegan; Xia Ren; Stephen G Hillier; W Colin Duncan
Journal: PLoS One Date: 2011-11-23 Impact factor: 3.240

36 in total

1. Old friends, new story: The role of Slit2C signaling through PlexinA1.

Authors: Juliane Schiweck; Marta Beauchamp; Muris Humo; Vincent Lelievre
Journal: Cell Adh Migr Date: 2015 Impact factor: 3.405

2. Identification of genes functionally involved in the detrimental effects of mutant histone H3.3-K27M in Drosophila melanogaster.

Authors: Johannes Berlandi; Amel Chaouch; Nicolas De Jay; Isabel Tegeder; Katharina Thiel; Margret Shirinian; Claudia L Kleinman; Astrid Jeibmann; Paul Lasko; Nada Jabado; Martin Hasselblatt
Journal: Neuro Oncol Date: 2019-05-06 Impact factor: 12.300

3. Silymarin suppresses HepG2 hepatocarcinoma cell progression through downregulation of Slit-2/Robo-1 pathway.

Authors: Nuriye Ezgi Bektur Aykanat; Sedat Kacar; Serife Karakaya; Varol Sahinturk
Journal: Pharmacol Rep Date: 2020-01-08 Impact factor: 3.024

Review 4. Roles of Slit Ligands and Their Roundabout (Robo) Family of Receptors in Bone Remodeling.

Authors: Tomoaki Niimi
Journal: Adv Exp Med Biol Date: 2021 Impact factor: 2.622

5. Whole-Genome Sequencing of Salivary Gland Adenoid Cystic Carcinoma.

Authors: Eleni M Rettig; C Conover Talbot; Mark Sausen; Sian Jones; Justin A Bishop; Laura D Wood; Collin Tokheim; Noushin Niknafs; Rachel Karchin; Elana J Fertig; Sarah J Wheelan; Luigi Marchionni; Michael Considine; Shizhang Ling; Carole Fakhry; Nickolas Papadopoulos; Kenneth W Kinzler; Bert Vogelstein; Patrick K Ha; Nishant Agrawal
Journal: Cancer Prev Res (Phila) Date: 2016-02-09

Review 6. Tumor progression: the neuronal input.

Authors: Marco Arese; Federico Bussolino; Margherita Pergolizzi; Laura Bizzozero; Davide Pascal
Journal: Ann Transl Med Date: 2018-03

7. Differential gene expression profiling of matched primary renal cell carcinoma and metastases reveals upregulation of extracellular matrix genes.

Authors: T H Ho; D J Serie; M Parasramka; J C Cheville; B M Bot; W Tan; L Wang; R W Joseph; T Hilton; B C Leibovich; A S Parker; J E Eckel-Passow
Journal: Ann Oncol Date: 2017-03-01 Impact factor: 32.976