Nariman Nezami1, Nariman Sepehrvand2, Mohammad Mirchi3, Behzad Salari4, Behrooz Shokouhi5, Morteza Ghojazadeh6, Mohammad Naghavi-Behzad7, Sona Ghorashi8, Fariba Mirzaie9, Hamid Noshad10, Afshar Zomorrodi11, Abasad Gharedaghi12, Savalan Babapoor-Farrokhran13, Saeedeh Mirbagheri14, Mohammad Kazem Tarzamni3. 1. Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran The Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins Hospital, Baltimore, USA. 2. Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran Canadian VIGOUR Centre, University of Alberta, Edmonton, Canada nariman256@gmail.com sepehrva@ualberta.ca. 3. Department of Radiology, Tabriz University of Medical Sciences, Tabriz, Iran. 4. Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran School of Medicine, Harvard University, Boston, USA. 5. Department of Pathology, Tabriz University of Medical Sciences, Tabriz, Iran. 6. Liver and Gastrointestinal Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. 7. Students' Research Committee, Medical Faculty, Tabriz University of Medical Sciences, Tabriz, Iran. 8. Young Researchers Club, Tabriz Branch, Islamic Azad University, Tabriz, Iran. 9. Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. 10. Department of Nephrology, Tabriz University of Medical Sciences, Tabriz, Iran. 11. Department of Transplantation, Tabriz University of Medical Sciences, Tabriz, Iran. 12. Department of Surgery, Tabriz University of Medical Sciences, Tabriz, Iran. 13. School of Medicine, Johns Hopkins Hospital, Baltimore, MD, USA. 14. The Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins Hospital, Baltimore, USA.
Abstract
AIM: We aimed to study the relationship of peripheral arteries' atherosclerosis with serum and tissue endothelin-1 in chronic kidney disease patients. METHODS: Ninety patients were enrolled, including 35 patients with chronic kidney disease (case group), 31 patients with coronary artery diseases who were candidates for coronary artery bypass grafting (positive control group), and 24 living kidney donors (negative control group). Intima-media thickness of the common carotid and femoral arteries was determined by ultrasonography. Serum and tissue endothelin-1 were measured by ELISA method. RESULTS: The mean serum and tissue endothelin-1 levels in the donor group were significantly lower than other groups (p < 0.001 for both). The coronary artery bypass grafting group had higher carotid and femoral intima-media thickness than other groups (p < 0.001), and the chronic kidney disease group had higher carotid and femoral intima-media thickness than the donor group (p < 0.001). Regression analysis in all groups did not reveal any correlation between the carotid intima-media thickness/femoral intima-media thickness and the serum/tissue endothelin-1. There was a direct linear correlation between the carotid and femoral intima-media thickness (p < 0.001) in all groups. CONCLUSIONS: Endothelin-1 level and intima-media thickness were higher in the chronic kidney disease patients and coronary artery bypass grafting candidates, without any correlation between endothelin-1 and peripheral arteries' intima-media thickness of both groups. Perhaps endothelin-1 rises and remains high upon endothelial damage and initiation of atherosclerosis.
AIM: We aimed to study the relationship of peripheral arteries' atherosclerosis with serum and tissue endothelin-1 in chronic kidney diseasepatients. METHODS: Ninety patients were enrolled, including 35 patients with chronic kidney disease (case group), 31 patients with coronary artery diseases who were candidates for coronary artery bypass grafting (positive control group), and 24 living kidney donors (negative control group). Intima-media thickness of the common carotid and femoral arteries was determined by ultrasonography. Serum and tissue endothelin-1 were measured by ELISA method. RESULTS: The mean serum and tissue endothelin-1 levels in the donor group were significantly lower than other groups (p < 0.001 for both). The coronary artery bypass grafting group had higher carotid and femoral intima-media thickness than other groups (p < 0.001), and the chronic kidney disease group had higher carotid and femoral intima-media thickness than the donor group (p < 0.001). Regression analysis in all groups did not reveal any correlation between the carotid intima-media thickness/femoral intima-media thickness and the serum/tissue endothelin-1. There was a direct linear correlation between the carotid and femoral intima-media thickness (p < 0.001) in all groups. CONCLUSIONS:Endothelin-1 level and intima-media thickness were higher in the chronic kidney diseasepatients and coronary artery bypass grafting candidates, without any correlation between endothelin-1 and peripheral arteries' intima-media thickness of both groups. Perhaps endothelin-1 rises and remains high upon endothelial damage and initiation of atherosclerosis.
Authors: Cornelia Then; Chaterina Sujana; Christian Herder; Holger Then; Margit Heier; Christa Meisinger; Annette Peters; Wolfgang Koenig; Wolfgang Rathmann; Haifa Maalmi; Katrin Ritzel; Michael Roden; Michael Stumvoll; Barbara Thorand; Jochen Seissler Journal: Vasc Health Risk Manag Date: 2022-05-03