Ryoma Michishita1, Chika Fukae1, Rikako Mihara1, Masahiro Ikenaga1, Kazuhiro Morimura1, Noriko Takeda2,3, Yosuke Yamada4,5, Yasuki Higaki1,4, Hiroaki Tanaka1,4, Akira Kiyonaga1,4. 1. Laboratory of Exercise Physiology, Faculty of Health and Sports Science, Fukuoka University, Fukuoka, Japan. 2. Japan Society for the Promotion of Science, Tokyo, Japan. 3. Faculty of Sport Sciences, Waseda University, Saitama, Japan. 4. Fukuoka University Institute for Physical Activity, Fukuoka, Japan. 5. Department of Nutritional Science, National Institute of Health and Nutrition, Tokyo, Japan.
Abstract
AIM: Increased physical activity can reduce the incidence of cardiovascular disease and the mortality rate. In contrast, a prolonged heart rate corrected-QT (QTc) interval is associated with an increased risk of arrhythmias, sudden cardiac death and coronary artery disease. The present cross-sectional study was designed to clarify the association between the physical activity level and the QTc interval in older adults. METHODS: The participants included 586 older adults (267 men and 319 women, age 71.2 ± 4.7 years) without a history of cardiovascular disease, who were taking cardioactive drugs. Electrocardiography was recorded with a standard resting 12-lead electrocardiograph, while the QTc interval was calculated according to Hodges' formula. The physical activity level was assessed using a triaxial accelerometer. The participants were divided into four categories, which were defined equally quartile distributions of the QTc interval. RESULTS: After adjusting for age, body mass index, waist circumference and the number of steps, the time spent in inactivity was higher and the time spent in light physical activity was significantly lower in the longest QTc interval group than in the shortest QTc interval group in both sexes (P < 0.05, respectively). However, there were no significant differences in the time spent in moderate and vigorous physical activities among the four groups in either sex. CONCLUSIONS: These results suggest that a decreased physical activity level, especially inactivity and light intensity physical activity, were associated with QTc interval in older adults.
AIM: Increased physical activity can reduce the incidence of cardiovascular disease and the mortality rate. In contrast, a prolonged heart rate corrected-QT (QTc) interval is associated with an increased risk of arrhythmias, sudden cardiac death and coronary artery disease. The present cross-sectional study was designed to clarify the association between the physical activity level and the QTc interval in older adults. METHODS: The participants included 586 older adults (267 men and 319 women, age 71.2 ± 4.7 years) without a history of cardiovascular disease, who were taking cardioactive drugs. Electrocardiography was recorded with a standard resting 12-lead electrocardiograph, while the QTc interval was calculated according to Hodges' formula. The physical activity level was assessed using a triaxial accelerometer. The participants were divided into four categories, which were defined equally quartile distributions of the QTc interval. RESULTS: After adjusting for age, body mass index, waist circumference and the number of steps, the time spent in inactivity was higher and the time spent in light physical activity was significantly lower in the longest QTc interval group than in the shortest QTc interval group in both sexes (P < 0.05, respectively). However, there were no significant differences in the time spent in moderate and vigorous physical activities among the four groups in either sex. CONCLUSIONS: These results suggest that a decreased physical activity level, especially inactivity and light intensity physical activity, were associated with QTc interval in older adults.
Authors: Jelena Kornej; Joanne M Murabito; Yuankai Zhang; Chunyu Liu; Ludovic Trinquart; Mayank Sardana; Emily S Manders; Michael M Hammond; Nicole L Spartano; Chathurangi H Pathiravasan; Xuzhi Wang; Belinda Borrelli; David D McManus; Emelia J Benjamin; Honghuang Lin Journal: Cardiovasc Digit Health J Date: 2021-11-23
Authors: Luigi Isaia Lecca; Igor Portoghese; Nicola Mucci; Maura Galletta; Federico Meloni; Ilaria Pilia; Gabriele Marcias; Daniele Fabbri; Jacopo Fostinelli; Roberto G Lucchini; Pierluigi Cocco; Marcello Campagna Journal: Int J Environ Res Public Health Date: 2019-11-28 Impact factor: 3.390