| Literature DB >> 25241685 |
Bin Chang1, Akihito Wada, Mitsuaki Hosoya, Tomohiro Oishi, Naruhiko Ishiwada, Megumi Oda, Tetsuya Sato, Yoshihiko Terauchi, Kenji Okada, Junichiro Nishi, Hideki Akeda, Hitoshi Kamiya, Makoto Ohnishi, Toshiaki Ihara.
Abstract
Group B Streptococcus (GBS) is one of the leading causes of neonatal bacterial infections. Population-based surveillance of GBS-related invasive diseases among newborns and infants from 10 prefectures in Japan was performed between 2007 and 2012. The characteristics of cases and isolated GBS are described in this study. The incidence rate of GBS-related invasive diseases was 0.13 per 1,000 live births. Analysis of GBS samples obtained from 60 invasive cases showed that the most frequent serotypes were III (48.3%), Ia (30.0%), and Ib (10.0%). All isolates were susceptible to penicillin G, ampicillin, cefotaxime, imipenem, and panipenem. However, 14, 2, and 7 isolates were resistant to erythromycin, clindamycin, and both erythromycin and clindamycin, respectively. Multilocus sequence typing revealed that GBS sequence type (ST) 23, ST17, and ST335 caused higher incidences of meningitis. These data show that serotypes III, Ia, and Ib together caused more than 80% of invasive infections in Japanese infants, and that GBS strains are still susceptible to β-lactam antibiotics.Entities:
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Year: 2014 PMID： 25241685 DOI： 10.7883/yoken.67.356
Source DB: PubMed Journal: Jpn J Infect Dis ISSN： 1344-6304 Impact factor: 1.362