| Literature DB >> 25240614 |
Quaovi Sodji1, Vishal Patil1, Surendra Jain2, James R Kornacki3, Milan Mrksich3, Babu L Tekwani4, Adegboyega K Oyelere5.
Abstract
Histone deacetylase inhibitors (HDACi) pleiotropy is largely due to their nonselective inhibition of various cellular HDAC isoforms. Connecting inhibition of a specific isoform to biological responses and/or phenotypes is essential toward deconvoluting HDACi pleiotropy. The contribution of classes I and II HDACs to the antileishmanial activity of HDACi was investigated using the amastigote and promastigote forms of Leishmania donovani. We observed that the antileishmanial activities of HDACi are largely due to the inhibition of HDAC6-like activity. This observation could facilitate the development of HDACi as antileishmanial agents.Entities:
Keywords: 3-Hydroxypyridin-2-thione; Histone deacetylase inhibitors; Leishmania donovani; Trichostatin A; Tubastatin A
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Year: 2014 PMID： 25240614 PMCID： PMC4225773 DOI： 10.1016/j.bmcl.2014.08.060
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823