Literature DB >> 25240199

Chaperone-mediated reversible inhibition of the sarcomeric myosin power stroke.

Paul Nicholls1, Paul J Bujalowski1, Henry F Epstein1, Darren F Boehning2, José M Barral3, Andres F Oberhauser4.   

Abstract

Molecular chaperones are required for successful folding and assembly of sarcomeric myosin in skeletal and cardiac muscle. Here, we show that the chaperone UNC-45B inhibits the actin translocation function of myosin. Further, we show that Hsp90, another chaperone involved in sarcomere development, allows the myosin to resume actin translocation. These previously unknown activities may play a key role in sarcomere development, preventing untimely myosin powerstrokes from disrupting the precise alignment of the sarcomere until it has formed completely.
Copyright © 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Actin-translocation; Chaperone; Hsp90; UNC-45

Mesh：

Substances：

Year:  2014        PMID： 25240199     DOI： 10.1016/j.febslet.2014.09.013

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  7 in total

1.  Mutations in conserved residues of the myosin chaperone UNC-45 result in both reduced stability and chaperoning activity.

Authors:  Taylor Moncrief; Courtney J Matheny; Ivana Gaziova; John M Miller; Hiroshi Qadota; Guy M Benian; Andres F Oberhauser
Journal:  Protein Sci       Date:  2021-09-28       Impact factor: 6.725

2.  Pathogenic Variants in the Myosin Chaperone UNC-45B Cause Progressive Myopathy with Eccentric Cores.

Authors:  Sandra Donkervoort; Carl E Kutzner; Ying Hu; Xavière Lornage; John Rendu; Tanya Stojkovic; Jonathan Baets; Sarah B Neuhaus; Jantima Tanboon; Reza Maroofian; Véronique Bolduc; Magdalena Mroczek; Stefan Conijn; Nancy L Kuntz; Ana Töpf; Soledad Monges; Fabiana Lubieniecki; Riley M McCarty; Katherine R Chao; Serena Governali; Johann Böhm; Kanokwan Boonyapisit; Edoardo Malfatti; Tumtip Sangruchi; Iren Horkayne-Szakaly; Carola Hedberg-Oldfors; Stephanie Efthymiou; Satoru Noguchi; Sarah Djeddi; Aritoshi Iida; Gabriella di Rosa; Chiara Fiorillo; Vincenzo Salpietro; Niklas Darin; Julien Fauré; Henry Houlden; Anders Oldfors; Ichizo Nishino; Willem de Ridder; Volker Straub; Wojciech Pokrzywa; Jocelyn Laporte; A Reghan Foley; Norma B Romero; Coen Ottenheijm; Thorsten Hoppe; Carsten G Bönnemann
Journal:  Am J Hum Genet       Date:  2020-11-19       Impact factor: 11.025

3.  TTC12 Loss-of-Function Mutations Cause Primary Ciliary Dyskinesia and Unveil Distinct Dynein Assembly Mechanisms in Motile Cilia Versus Flagella.

Authors:  Lucie Thomas; Khaled Bouhouche; Marjorie Whitfield; Guillaume Thouvenin; Andre Coste; Bruno Louis; Claire Szymanski; Emilie Bequignon; Jean-François Papon; Manon Castelli; Michel Lemullois; Xavier Dhalluin; Valérie Drouin-Garraud; Guy Montantin; Sylvie Tissier; Philippe Duquesnoy; Bruno Copin; Florence Dastot; Sandrine Couvet; Anne-Laure Barbotin; Catherine Faucon; Isabelle Honore; Bernard Maitre; Nicole Beydon; Aline Tamalet; Nathalie Rives; France Koll; Estelle Escudier; Anne-Marie Tassin; Aminata Touré; Valérie Mitchell; Serge Amselem; Marie Legendre
Journal:  Am J Hum Genet       Date:  2020-01-23       Impact factor: 11.025

4.  Translocation of molecular chaperones to the titin springs is common in skeletal myopathy patients and affects sarcomere function.

Authors:  Andreas Unger; Lisa Beckendorf; Pierre Böhme; Rudolf Kley; Marion von Frieling-Salewsky; Hanns Lochmüller; Rolf Schröder; Dieter O Fürst; Matthias Vorgerd; Wolfgang A Linke
Journal:  Acta Neuropathol Commun       Date:  2017-09-15       Impact factor: 7.801

5.  The central domain of UNC-45 chaperone inhibits the myosin power stroke.

Authors:  Paul J Bujalowski; Paul Nicholls; Eleno Garza; Andres F Oberhauser
Journal:  FEBS Open Bio       Date:  2017-12-10       Impact factor: 2.693

Review 6.  UCS Chaperone Folding of the Myosin Head: A Function That Evolved before Animals and Fungi Diverged from a Common Ancestor More than a Billion Years Ago.

Authors:  Peter William Piper; Julia Elizabeth Scott; Stefan Heber Millson
Journal:  Biomolecules       Date:  2022-07-26

7.  Mutational Analysis of the Structure and Function of the Chaperoning Domain of UNC-45B.

Authors:  Ivana Gaziova; Taylor Moncrief; Courtney J Christian; Michael Villarreal; Simon Powell; Hubert Lee; Hiroshi Qadota; Mark A White; Guy M Benian; Andres F Oberhauser
Journal:  Biophys J       Date:  2020-07-22       Impact factor: 4.033
  7 in total

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