Literature DB >> 2523972

Molecular genetics in the National Health Service in Britain.

R Harris1, R Elles, D Craufurd, A Dodge, A Ivinson, K Hodgkinson, R Mountford, M Schwartz, T Strachan, A Read.   

Abstract

A recent report from the Departments of Health draws attention to the value of DNA diagnosis for inherited diseases and the need for planning these services in the National Health Service. There is great potential for preventive medicine, but a major immediate benefit is the newfound ability to exclude the carrier state in many people at risk and to protect fetuses from abortion when, as in most cases, they are shown to be normal by DNA tests. However, the widespread application of these new techniques requires prior evaluation and general acceptance. This will only be obtained after public debate, education of professionals and the population, and the establishment of adequate non-directive genetic counselling services. Some of the points to be considered in setting up molecular genetics laboratories are described.

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Year:  1989        PMID: 2523972      PMCID: PMC1017294          DOI: 10.1136/jmg.26.4.219

Source DB:  PubMed          Journal:  J Med Genet        ISSN: 0022-2593            Impact factor:   6.318


  19 in total

1.  A report on genetic registers. Based on the report of the Clinical Genetics Society Working Party.

Authors:  A E Emery; C Brough; M Crawfurd; P Harper; R Harris; G Oakshott
Journal:  J Med Genet       Date:  1978-12       Impact factor: 6.318

2.  Guidelines for DNA banking. Report of the Clinical Genetics Society working party on DNA banking.

Authors:  J R Yates; S Malcolm; A P Read
Journal:  J Med Genet       Date:  1989-04       Impact factor: 6.318

3.  Ethics of predictive testing for Huntington's chorea: the need for more information.

Authors:  D I Craufurd; R Harris
Journal:  Br Med J (Clin Res Ed)       Date:  1986-07-26

4.  Effect of fetal diagnostic testing on birth-rate of thalassaemia major in Britain.

Authors:  B Modell; M Petrou; R H Ward; D V Fairweather; C Rodeck; L A Varnavides; J M White
Journal:  Lancet       Date:  1984-12-15       Impact factor: 79.321

5.  First-trimester prenatal diagnosis of cystic fibrosis with linked DNA probes.

Authors:  M Farrall; H Y Law; C H Rodeck; R Warren; P Stanier; M Super; W Lissens; P Scambler; E Watson; B Wainwright
Journal:  Lancet       Date:  1986-06-21       Impact factor: 79.321

6.  A polymorphic DNA marker genetically linked to Huntington's disease.

Authors:  J F Gusella; N S Wexler; P M Conneally; S L Naylor; M A Anderson; R E Tanzi; P C Watkins; K Ottina; M R Wallace; A Y Sakaguchi
Journal:  Nature       Date:  1983 Nov 17-23       Impact factor: 49.962

7.  A closely linked genetic marker for cystic fibrosis.

Authors:  R White; S Woodward; M Leppert; P O'Connell; M Hoff; J Herbst; J M Lalouel; M Dean; G Vande Woude
Journal:  Nature       Date:  1985 Nov 28-Dec 4       Impact factor: 49.962

8.  Cystic fibrosis locus defined by a genetically linked polymorphic DNA marker.

Authors:  L C Tsui; M Buchwald; D Barker; J C Braman; R Knowlton; J W Schumm; H Eiberg; J Mohr; D Kennedy; N Plavsic
Journal:  Science       Date:  1985-11-29       Impact factor: 47.728

9.  A highly polymorphic DNA marker linked to adult polycystic kidney disease on chromosome 16.

Authors:  S T Reeders; M H Breuning; K E Davies; R D Nicholls; A P Jarman; D R Higgs; P L Pearson; D J Weatherall
Journal:  Nature       Date:  1985 Oct 10-16       Impact factor: 49.962

10.  Localization of cystic fibrosis locus to human chromosome 7cen-q22.

Authors:  B J Wainwright; P J Scambler; J Schmidtke; E A Watson; H Y Law; M Farrall; H J Cooke; H Eiberg; R Williamson
Journal:  Nature       Date:  1985 Nov 28-Dec 4       Impact factor: 49.962

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  9 in total

1.  Implications for medical genetics of the House of Commons Science and Technology Committee's report on human genetics.

Authors:  R Harris
Journal:  J Med Genet       Date:  1996-04       Impact factor: 6.318

Review 2.  An overview of clinical molecular genetics.

Authors:  R Elles
Journal:  Mol Biotechnol       Date:  1997-10       Impact factor: 2.695

3.  Are abortions more or less frequent once prenatal diagnosis is available?

Authors:  S Bundey; E Boughton
Journal:  J Med Genet       Date:  1989-12       Impact factor: 6.318

4.  Molecular genetics as a diagnostic service.

Authors:  P S Harper
Journal:  J Med Genet       Date:  1989-04       Impact factor: 6.318

5.  Evaluation of a project to enhance knowledge of hereditary diseases and management.

Authors:  I R Walpole; C Watson; D Moore; J Goldblatt; C Bower
Journal:  J Med Genet       Date:  1997-10       Impact factor: 6.318

6.  UK clinicians' knowledge of and attitudes to the prenatal diagnosis of single gene disorders.

Authors:  H V Firth; R H Lindenbaum
Journal:  J Med Genet       Date:  1992-01       Impact factor: 6.318

7.  A consortium approach to molecular genetic services. Scottish Molecular Genetics Consortium.

Authors:  D J Brock
Journal:  J Med Genet       Date:  1990-01       Impact factor: 6.318

8.  The new genetics: a challenge to traditional medicine. Based on the Milroy Lecture 1989.

Authors:  R Harris
Journal:  J R Coll Physicians Lond       Date:  1991-04

9.  Citizens under the umbrella: citizenship projects and the development of genetic umbrella organizations in the USA and the UK.

Authors:  Koichi Mikami
Journal:  New Genet Soc       Date:  2020-03-06
  9 in total

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