OBJECTIVE: To summarize the diagnosis, surgical intervention and postoperative management of patients with urothelial cancer (UC) after renal transplants (RTx). METHODS: In our retrospective review of 3,370 RTx recipients in our transplant center from 1974 to 2012, all recipients underwent routine checkups and follow-up. Imaging was performed in all patients suspected of having malignancies, and the histological cell type of the specimen slices was reappraised by pathologists. The data of all recipients with malignancies were retrospectively reviewed to determine clinical characteristics after RTx. RESULTS: A total of 169 patients of the cohort of 3,370 had malignancies after RTx. Of 180 tumors, 106 tumors were confirmed as UC. Fifty-two patients had taken drugs containing aristolochic acid. The median time to neoplasia after RTx in the group taking aristolochic acid (30 months) was significantly less than in those not taking aristolochic acid (60.3 months). We recommended surgical intervention for RTx recipients with UC, transurethral resection of bladder tumors for patients with solitary or concomitant superficial UC, and radical cystectomy for high-risk bladder UC. We performed simultaneous bilateral or unilateral nephroureterectomy in patients with upper urinary tract UC. CONCLUSION: Our results suggest that UC is the predominant tumor in Chinese RTx recipients and that regular urinalysis and imaging are needed in all recipients after RTx, especially women with a history of taking aristolochic acid. Surgical interventions did not increase the risk beyond that in UC patients without RTx.
OBJECTIVE: To summarize the diagnosis, surgical intervention and postoperative management of patients with urothelial cancer (UC) after renal transplants (RTx). METHODS: In our retrospective review of 3,370 RTx recipients in our transplant center from 1974 to 2012, all recipients underwent routine checkups and follow-up. Imaging was performed in all patients suspected of having malignancies, and the histological cell type of the specimen slices was reappraised by pathologists. The data of all recipients with malignancies were retrospectively reviewed to determine clinical characteristics after RTx. RESULTS: A total of 169 patients of the cohort of 3,370 had malignancies after RTx. Of 180 tumors, 106 tumors were confirmed as UC. Fifty-two patients had taken drugs containing aristolochic acid. The median time to neoplasia after RTx in the group taking aristolochic acid (30 months) was significantly less than in those not taking aristolochic acid (60.3 months). We recommended surgical intervention for RTx recipients with UC, transurethral resection of bladder tumors for patients with solitary or concomitant superficial UC, and radical cystectomy for high-risk bladder UC. We performed simultaneous bilateral or unilateral nephroureterectomy in patients with upper urinary tract UC. CONCLUSION: Our results suggest that UC is the predominant tumor in Chinese RTx recipients and that regular urinalysis and imaging are needed in all recipients after RTx, especially women with a history of taking aristolochic acid. Surgical interventions did not increase the risk beyond that in UC patients without RTx.
Authors: M L Galve; V Cuervas-Mons; J Figueras; I Herrero; M Mata; G Clemente; M Prieto; C Margarit; A Bernardos; F Casafont Journal: Transplant Proc Date: 1999 Feb-Mar Impact factor: 1.066
Authors: S A Birkeland; H H Storm; L U Lamm; L Barlow; I Blohmé; B Forsberg; B Eklund; O Fjeldborg; M Friedberg; L Frödin Journal: Int J Cancer Date: 1995-01-17 Impact factor: 7.396
Authors: Karim Chamie; Mark S Litwin; Jeffrey C Bassett; Timothy J Daskivich; Julie Lai; Jan M Hanley; Badrinath R Konety; Christopher S Saigal Journal: Cancer Date: 2013-06-04 Impact factor: 6.860
Authors: Gaetano La Manna; Serena Corsini; Sandra Iannelli; Maria Laura Cappuccilli; Giorgia Comai; Mario Iorio; Paola Todeschini; Elisa Carretta; Maria Piera Scolari; Andrea Bontadini; Segio Stefoni Journal: Ann Transplant Date: 2013-11-13 Impact factor: 1.530
Authors: Ines A Ederer; Ilaria Lucca; Sebastian L Hofbauer; Michael Haidinger; Andrea Haitel; Martin Susani; Shahrokh F Shariat; Tobias Klatte Journal: World J Urol Date: 2015-04-10 Impact factor: 4.226
Authors: Cristian Axel Hernández-Gaytán; Francisco Rodríguez-Covarrubias; Ricardo A Castillejos-Molina; Andrés Hernández-Porras; Ignacio Tobia; Justin M Dubin; Ana María Autrán-Gómez Journal: Curr Urol Rep Date: 2021-12-16 Impact factor: 3.092