Fabiane Araújo Sampaio1, Mayara Monte Feitosa2, Cristiane Hermes Sales3, Danilla Michelle Costa e Silva4, Kyria Jayanne Clímaco Cruz5, Francisco Erasmo Oliveira6, Célia Colli7, Dilina do Nascimento Marreiro8. 1. Postgraduate Program in Sciences and Health. Federal University of Piauí. Teresina. Piauí. Brazil.. fabianesampaio21@gmail.com. 2. Department of Nutrition. Federal University of Piauí. Teresina. Piauí. Brazil.. mayarafeitosa@hotmail.com. 3. Department of Food and Experimental Nutrition, Faculty of Pharmaceutical Sciences, University of São Paulo. São Paulo. Brazil.. cristianehermes@yahoo.com.br. 4. Postgraduate Program in Sciences and Health. Federal University of Piauí. Teresina. Piauí. Brazil.. dmcsilva@bol.com.br. 5. Department of Nutrition. Federal University of Piauí. Teresina. Piauí. Brazil.. kyriajayanne@hotmail.com. 6. Lab Med Imagem, Teresina, Piauí, Brazil.. erasmo@medimagem.com.br. 7. Department of Food and Experimental Nutrition, Faculty of Pharmaceutical Sciences, University of São Paulo. São Paulo. Brazil.. cecolli@usp.br. 8. Department of Nutrition. Federal University of Piauí. Teresina. Piauí. Brazil.. dilina.marreiro@gmail.com.
Abstract
INTRODUCTION: Studies have shown that oxidative stress, found in patients with type 2 diabetes, may be due to changes in the metabolism of minerals, such as magnesium and iron. Data related to compartmentalization of these minerals in diabetes are scarce and controversial. OBJECTIVE: This study assessed the influence of magnesium on biochemical parameters of iron and oxidative stress in patients with type 2 diabetes. METHODS: A case-control study in male and female subjects aged 27-59 years, divided into two groups: type 2 diabetes (n=40) and control (n=48). Intake of magnesium and iron was assessed by three-day food record. Plasma, erythrocyte and urinary levels of magnesium, serum iron, ferritin, total iron binding capacity, fasting glucose, glycated hemoglobin, insulin, creatinine clearance and plasma thiobarbituric acid reactive substances (TBARS) were analyzed. RESULTS AND DISCUSSION: Magnesium intake and plasma magnesium were lower in diabetic subjects. There was low urinary magnesium excretion, with no difference between groups. Although normal, the diabetic group had lower serum iron and ferritin concentrations compared to control subjects. Plasma TBARS in diabetic patients was higher than control while creatinine clearance was lower. An inverse correlation between erythrocyte magnesium and serum iron and ferritin was observed in the diabetes group. CONCLUSIONS: Diabetes induced hypomagnesemia and this, associated with chronic hyperglycemia, may have enhanced oxidative stress. Erythrocyte magnesium may have contributed to prevent iron overload and worsening of oxidative stress and hyperglycemic status. Copyright AULA MEDICA EDICIONES 2014. Published by AULA MEDICA. All rights reserved.
INTRODUCTION: Studies have shown that oxidative stress, found in patients with type 2 diabetes, may be due to changes in the metabolism of minerals, such as magnesium and iron. Data related to compartmentalization of these minerals in diabetes are scarce and controversial. OBJECTIVE: This study assessed the influence of magnesium on biochemical parameters of iron and oxidative stress in patients with type 2 diabetes. METHODS: A case-control study in male and female subjects aged 27-59 years, divided into two groups: type 2 diabetes (n=40) and control (n=48). Intake of magnesium and iron was assessed by three-day food record. Plasma, erythrocyte and urinary levels of magnesium, serum iron, ferritin, total iron binding capacity, fasting glucose, glycated hemoglobin, insulin, creatinine clearance and plasma thiobarbituric acid reactive substances (TBARS) were analyzed. RESULTS AND DISCUSSION: Magnesium intake and plasma magnesium were lower in diabetic subjects. There was low urinary magnesium excretion, with no difference between groups. Although normal, the diabetic group had lower serum iron and ferritin concentrations compared to control subjects. Plasma TBARS in diabeticpatients was higher than control while creatinine clearance was lower. An inverse correlation between erythrocyte magnesium and serum iron and ferritin was observed in the diabetes group. CONCLUSIONS:Diabetes induced hypomagnesemia and this, associated with chronic hyperglycemia, may have enhanced oxidative stress. Erythrocyte magnesium may have contributed to prevent iron overload and worsening of oxidative stress and hyperglycemic status. Copyright AULA MEDICA EDICIONES 2014. Published by AULA MEDICA. All rights reserved.
Authors: Juan R Muñoz-Castañeda; María V Pendón-Ruiz de Mier; Mariano Rodríguez; María E Rodríguez-Ortiz Journal: Int J Mol Sci Date: 2018-02-27 Impact factor: 5.923