Dan L Waitzberg1, Priscila Garla2. 1. Departamento de Gastroenterología de la Facultad de Medicina de la Universidad de São Paulo.. dan@ganep.com.br. 2. Laboratorio de Investigación Médica LIM 35 - FMUSP. Brasil.. prigarla@gmail.com.
Abstract
INTRODUCTION: A decline in memory and cognitive function is considered to be a normal consequence of aging. Polyunsaturated omega-3 fatty acids are increasingly proposed as dietary supplements with the ability to reduce the risk of cognitive decline, including Alzheimer's disease (AD). AIM: To study the effect of omega-3 on cognitive decline through the review of recent observational, interventional, and experimental studies. METHODS: We conducted a Pubmed, Medline, Cochrane and Embase search for epidemiological and clinical studies in the international literature using combinations of the following keywords: "Alzheimer's disease", "mild cognitive impairment", "cognitive function", "dietary factors", "omega-3 fatty acids", "EPA and DHA". CONCLUSIONS: Studies have shown the protective role of omega-3 fatty acids in mild cognitive impairment, dementia, and the risk and progression of Alzheimer's disease in the elderly. Further studies are needed to understand the mechanism of action of omega-3 fatty acids on cognition. Doses, composition of EPA and DHA capsules and time of supplementation should be explored. Copyright AULA MEDICA EDICIONES 2014. Published by AULA MEDICA. All rights reserved.
INTRODUCTION: A decline in memory and cognitive function is considered to be a normal consequence of aging. Polyunsaturated omega-3 fatty acids are increasingly proposed as dietary supplements with the ability to reduce the risk of cognitive decline, including Alzheimer's disease (AD). AIM: To study the effect of omega-3 on cognitive decline through the review of recent observational, interventional, and experimental studies. METHODS: We conducted a Pubmed, Medline, Cochrane and Embase search for epidemiological and clinical studies in the international literature using combinations of the following keywords: "Alzheimer's disease", "mild cognitive impairment", "cognitive function", "dietary factors", "omega-3 fatty acids", "EPA and DHA". CONCLUSIONS: Studies have shown the protective role of omega-3 fatty acids in mild cognitive impairment, dementia, and the risk and progression of Alzheimer's disease in the elderly. Further studies are needed to understand the mechanism of action of omega-3 fatty acids on cognition. Doses, composition of EPA and DHA capsules and time of supplementation should be explored. Copyright AULA MEDICA EDICIONES 2014. Published by AULA MEDICA. All rights reserved.
Authors: Joaquin Baleztena; Miguel Ruiz-Canela; Carmen Sayon-Orea; Maria Pardo; Teresa Añorbe; Jose Ignacio Gost; Carmen Gomez; Belen Ilarregui; Maira Bes-Rastrollo Journal: PLoS One Date: 2018-03-26 Impact factor: 3.240