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Literature DB >> 25237102

Cord blood expansion. Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal.

Iman Fares¹, Jalila Chagraoui¹, Yves Gareau², Stéphane Gingras², Réjean Ruel², Nadine Mayotte¹, Elizabeth Csaszar³, David J H F Knapp⁴, Paul Miller⁴, Mor Ngom⁴, Suzan Imren⁴, Denis-Claude Roy⁵, Kori L Watts⁶, Hans-Peter Kiem⁷, Robert Herrington⁸, Norman N Iscove⁹, R Keith Humphries⁴, Connie J Eaves⁴, Sandra Cohen⁵, Anne Marinier², Peter W Zandstra³, Guy Sauvageau¹⁰.

Abstract

The small number of hematopoietic stem and progenitor cells in cord blood units limits their widespread use in human transplant protocols. We identified a family of chemically related small molecules that stimulates the expansion ex vivo of human cord blood cells capable of reconstituting human hematopoiesis for at least 6 months in immunocompromised mice. The potent activity of these newly identified compounds, UM171 being the prototype, is independent of suppression of the aryl hydrocarbon receptor, which targets cells with more-limited regenerative potential. The properties of UM171 make it a potential candidate for hematopoietic stem cell transplantation and gene therapy.

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 2014 PMID： 25237102 PMCID： PMC4372335 DOI： 10.1126/science.1256337

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

17 in total

1. Rapid expansion of human hematopoietic stem cells by automated control of inhibitory feedback signaling.

Authors: Elizabeth Csaszar; Daniel C Kirouac; Mei Yu; WeiJia Wang; Wenlian Qiao; Michael P Cooke; Anthony E Boitano; Caryn Ito; Peter W Zandstra
Journal: Cell Stem Cell Date: 2012-02-03 Impact factor: 24.633

2. Endothelial protein C receptor (CD201) explicitly identifies hematopoietic stem cells in murine bone marrow.

Authors: Alejandro B Balazs; Attila J Fabian; Charles T Esmon; Richard C Mulligan
Journal: Blood Date: 2005-11-22 Impact factor: 22.113

3. Hematopoietic stem cell subtypes expand differentially during development and display distinct lymphopoietic programs.

Authors: Claudia Benz; Michael R Copley; David G Kent; Stefan Wohrer; Adrian Cortes; Nima Aghaeepour; Elaine Ma; Heidi Mader; Keegan Rowe; Christopher Day; David Treloar; Ryan R Brinkman; Connie J Eaves
Journal: Cell Stem Cell Date: 2012-03-02 Impact factor: 24.633

4. Genotypic and functional diversity of phenotypically defined primitive hematopoietic cells in patients with chronic myeloid leukemia.

Authors: Ivan Sloma; Philip A Beer; Kyi Min Saw; Matthew Chan; Donna Leung; Kamini Raghuram; Cedric Brimacombe; Bobby Johnston; Karen Lambie; Donna Forrest; Xiaoyan Jiang; Connie J Eaves
Journal: Exp Hematol Date: 2013-07-11 Impact factor: 3.084

5. Flavone antagonists bind competitively with 2,3,7, 8-tetrachlorodibenzo-p-dioxin (TCDD) to the aryl hydrocarbon receptor but inhibit nuclear uptake and transformation.

Authors: E C Henry; A S Kende; G Rucci; M J Totleben; J J Willey; S D Dertinger; R S Pollenz; J P Jones; T A Gasiewicz
Journal: Mol Pharmacol Date: 1999-04 Impact factor: 4.436

6. Transplants of umbilical-cord blood or bone marrow from unrelated donors in adults with acute leukemia.

Authors: Vanderson Rocha; Myriam Labopin; Guillermo Sanz; William Arcese; Rainer Schwerdtfeger; Alberto Bosi; Niels Jacobsen; Tapani Ruutu; Marcos de Lima; Jürgen Finke; Francesco Frassoni; Eliane Gluckman
Journal: N Engl J Med Date: 2004-11-25 Impact factor: 91.245

7. HLA match likelihoods for hematopoietic stem-cell grafts in the U.S. registry.

Authors: Loren Gragert; Mary Eapen; Eric Williams; John Freeman; Stephen Spellman; Robert Baitty; Robert Hartzman; J Douglas Rizzo; Mary Horowitz; Dennis Confer; Martin Maiers
Journal: N Engl J Med Date: 2014-07-24 Impact factor: 91.245

8. Long-term propagation of distinct hematopoietic differentiation programs in vivo.

Authors: Brad Dykstra; David Kent; Michelle Bowie; Lindsay McCaffrey; Melisa Hamilton; Kristin Lyons; Shang-Jung Lee; Ryan Brinkman; Connie Eaves
Journal: Cell Stem Cell Date: 2007-08-16 Impact factor: 24.633

9. Analysis of the clonal growth and differentiation dynamics of primitive barcoded human cord blood cells in NSG mice.

Authors: Alice M S Cheung; Long V Nguyen; Annaick Carles; Philip Beer; Paul H Miller; David J H F Knapp; Kiran Dhillon; Martin Hirst; Connie J Eaves
Journal: Blood Date: 2013-09-12 Impact factor: 22.113

Review 10. Umbilical cord blood graft enhancement strategies: has the time come to move these into the clinic?

Authors: M Norkin; H M Lazarus; J R Wingard
Journal: Bone Marrow Transplant Date: 2012-09-03 Impact factor: 5.483

195 in total

Review 1. Genetic treatment of a molecular disorder: gene therapy approaches to sickle cell disease.

Authors: Megan D Hoban; Stuart H Orkin; Daniel E Bauer
Journal: Blood Date: 2016-01-12 Impact factor: 22.113

2. Patching up hematopoietic stem cells.

Authors: Giorgia Santilli; Adrian J Thrasher
Journal: Nat Biotechnol Date: 2015-12-09 Impact factor: 54.908

3. Vascular niche promotes hematopoietic multipotent progenitor formation from pluripotent stem cells.

Authors: Jennifer L Gori; Jason M Butler; Yan-Yi Chan; Devikha Chandrasekaran; Michael G Poulos; Michael Ginsberg; Daniel J Nolan; Olivier Elemento; Brent L Wood; Jennifer E Adair; Shahin Rafii; Hans-Peter Kiem
Journal: J Clin Invest Date: 2015-02-09 Impact factor: 14.808

4. Glucocorticoid hormone-induced chromatin remodeling enhances human hematopoietic stem cell homing and engraftment.

Authors: Bin Guo; Xinxin Huang; Scott Cooper; Hal E Broxmeyer
Journal: Nat Med Date: 2017-03-06 Impact factor: 53.440

5. Maintenance and enhancement of human peripheral blood mobilized stem/progenitor cell engraftment after ex vivo culture via an HDACi/SALL4 axis (3465).

Authors: Hiro Tatetsu; Myriam Armant; Fei Wang; Chong Gao; Shikiko Ueno; Xi Tian; Alex Federation; Jun Qi; James Bradner; Daniel G Tenen; Li Chai
Journal: Exp Hematol Date: 2019-06-28 Impact factor: 3.084

6. Induction of human hemogenesis in adult fibroblasts by defined factors and hematopoietic coculture.

Authors: Michael G Daniel; David Sachs; Jeffrey M Bernitz; Yesai Fstkchyan; Katrina Rapp; Namita Satija; Kenneth Law; Foram Patel; Andreia M Gomes; Huen-Suk Kim; Carlos-Filipe Pereira; Benjamin Chen; Ihor R Lemischka; Kateri A Moore
Journal: FEBS Lett Date: 2019-10-12 Impact factor: 4.124