Stefanie Corradini1, Maximilian Niyazi2, Olivier M Niemoeller2, Minglun Li2, Falk Roeder2, Renate Eckel3, Gabriele Schubert-Fritschle3, Heike R Scheithauer2, Nadia Harbeck4, Jutta Engel3, Claus Belka2. 1. Department of Radiation Oncology, University of Munich, Germany. Electronic address: stefanie.corradini@med.uni-muenchen.de. 2. Department of Radiation Oncology, University of Munich, Germany. 3. Munich Cancer Registry (MCR) of the Munich Cancer Centre (MCC) at the Department of Medical Informatics, Biometry and Epidemiology (IBE), University of Munich, Germany. 4. Breast Center, Department of Obstetrics and Gynecology, University of Munich, Germany; Comprehensive Cancer Center (CCC-LMU), University of Munich, Germany.
Abstract
PURPOSE: The purpose of this retrospective outcome study was to validate the effectiveness of postoperative radiotherapy in breast conserving therapy (BCT) and to evaluate possible causes for omission of radiotherapy after breast conserving surgery (BCS) in a non-trial population. METHODS: Data were provided by the population-based Munich Cancer Registry. The study included epidemiological data of 30.811 patients diagnosed with breast cancer from 1998 to 2012. The effect of omitting radiotherapy was analysed using Kaplan-Meier-estimates and Cox proportional hazard regression. Variables predicting omission of radiotherapy were analysed using multivariate logistic regression. RESULTS: Use of postoperative radiotherapy after BCS was associated with significant improvements in local control and survival. 10-year loco-regional recurrence-free-survival was 90.8% with postoperative radiotherapy vs. 77.6% with surgery alone (p<0.001). 10-year overall survival rates were 55.2% with surgery alone vs. 82.2% following postoperative radiotherapy (p<0.001). Variables predicting omission of postoperative radiotherapy included advanced age (women ⩾80 years; OR: 0.082; 95% CI: 0.071-0.094, p<0.001). CONCLUSIONS: This study shows a decrease in local control and a survival disadvantage if postoperative radiotherapy after breast conserving surgery is omitted in an unselected cohort of primary breast cancer patients. Due to its epidemiological nature, it cannot answer the question in whom postoperative radiotherapy can be safely omitted.
PURPOSE: The purpose of this retrospective outcome study was to validate the effectiveness of postoperative radiotherapy in breast conserving therapy (BCT) and to evaluate possible causes for omission of radiotherapy after breast conserving surgery (BCS) in a non-trial population. METHODS: Data were provided by the population-based Munich Cancer Registry. The study included epidemiological data of 30.811 patients diagnosed with breast cancer from 1998 to 2012. The effect of omitting radiotherapy was analysed using Kaplan-Meier-estimates and Cox proportional hazard regression. Variables predicting omission of radiotherapy were analysed using multivariate logistic regression. RESULTS: Use of postoperative radiotherapy after BCS was associated with significant improvements in local control and survival. 10-year loco-regional recurrence-free-survival was 90.8% with postoperative radiotherapy vs. 77.6% with surgery alone (p<0.001). 10-year overall survival rates were 55.2% with surgery alone vs. 82.2% following postoperative radiotherapy (p<0.001). Variables predicting omission of postoperative radiotherapy included advanced age (women ⩾80 years; OR: 0.082; 95% CI: 0.071-0.094, p<0.001). CONCLUSIONS: This study shows a decrease in local control and a survival disadvantage if postoperative radiotherapy after breast conserving surgery is omitted in an unselected cohort of primary breast cancerpatients. Due to its epidemiological nature, it cannot answer the question in whom postoperative radiotherapy can be safely omitted.
Authors: Stefanie Corradini; Hendrik Ballhausen; Helmut Weingandt; Philipp Freislederer; Stephan Schönecker; Maximilian Niyazi; Cristoforo Simonetto; Markus Eidemüller; Ute Ganswindt; Claus Belka Journal: Strahlenther Onkol Date: 2017-09-15 Impact factor: 3.621
Authors: Montserrat Pazos; Stephan Schönecker; Daniel Reitz; Paul Rogowski; Maximilian Niyazi; Filippo Alongi; Christiane Matuschek; Michael Braun; Nadia Harbeck; Claus Belka; Stefanie Corradini Journal: Breast Care (Basel) Date: 2018-05-24 Impact factor: 2.860
Authors: Bárbara Lara-Chacón; Sandra L Guerrero-Rodríguez; Karla J Ramírez-Hernández; Angélica Yamilett Robledo-Rivera; Marco Antonio Velasco Velazquez; Roberto Sánchez-Olea; Mónica Raquel Calera Journal: Technol Cancer Res Treat Date: 2019-01-01