Literature DB >> 25231340

Cytotoxic 5α,8α-epidioxy sterols from the marine sponge Monanchora sp.

Bora Mun1, Weihong Wang, Hiyoung Kim, Dongyup Hahn, Inho Yang, Dong Hwan Won, Eun-hee Kim, Jihye Lee, Chulkyeong Han, Hyunji Kim, Merrick Ekins, Sang-Jip Nam, Hyukjae Choi, Heonjoong Kang.   

Abstract

Three new sterols, 5α,8α-epidioxy-24-norcholesta-6,9(11),22-trien-3β-ol (1), 5α,8α-epidioxy-cholesta-6,9(11),24-trien-3β-ol (2), and 5α,8α-epidioxy-cholesta-6,23-dien-3β,25-diol (3), with four known sterols (4-7) were isolated from a marine sponge Monanchora sp. Their chemical structures were elucidated by extensive spectroscopic analysis. Compounds 1 and 3-7 showed moderate cytotoxicity against several human carcinoma cell lines including renal (A-498), pancreatic (PANC-1 and MIA PaCa-2), and colorectal (HCT 116) cancer cell lines.

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Year:  2014        PMID： 25231340     DOI： 10.1007/s12272-014-0480-8

Source DB:  PubMed          Journal:  Arch Pharm Res        ISSN： 0253-6269            Impact factor:   4.946


  8 in total

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