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Literature DB >> 25231306

Molecular requirement for sterols in herpes simplex virus entry and infectivity.

George A Wudiri¹, Suzanne M Pritchard², Hong Li³, Jin Liu⁴, Hector C Aguilar⁵, Stacey D Gilk⁶, Anthony V Nicola⁷.

Abstract

Herpes simplex virus 1 (HSV-1) required cholesterol or desmosterol for virion-induced membrane fusion. HSV successfully entered DHCR24(-/-) cells, which lack a desmosterol-to-cholesterol conversion enzyme, indicating that entry can occur independently of cholesterol. Depletion of desmosterol from these cells resulted in diminished HSV-1 entry, suggesting a general sterol requirement for HSV-1 entry and that desmosterol can operate in virus entry. Cholesterol functioned more effectively than desmosterol, suggesting that the hydrocarbon tail of cholesterol influences viral entry.

Entities: Chemical Gene Species

Mesh：

Substances：
Desmosterol
Cholesterol

Year: 2014 PMID： 25231306 PMCID： PMC4248969 DOI： 10.1128/JVI.01615-14

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

27 in total

1. αVβ3-integrin relocalizes nectin1 and routes herpes simplex virus to lipid rafts.

Authors: Tatiana Gianni; Gabriella Campadelli-Fiume
Journal: J Virol Date: 2011-12-14 Impact factor: 5.103

2. Cellular proteasome activity facilitates herpes simplex virus entry at a postpenetration step.

Authors: Mark G Delboy; Devin G Roller; Anthony V Nicola
Journal: J Virol Date: 2008-01-30 Impact factor: 5.103

3. Desmosterol can replace cholesterol in sustaining cell proliferation and regulating the SREBP pathway in a sterol-Delta24-reductase-deficient cell line.

Authors: Sara Rodríguez-Acebes; Paloma de la Cueva; Carlos Fernández-Hernando; Antonio J Ferruelo; Miguel A Lasunción; Robert B Rawson; Javier Martínez-Botas; Diego Gómez-Coronado
Journal: Biochem J Date: 2009-05-13 Impact factor: 3.857

Review 4. Alphaherpesvirus use and misuse of cellular actin and cholesterol.

Authors: Herman W Favoreel; Céline Van den Broeke; Ann Desplanques; Matthias Deruelle; Geert Van Minnebruggen; Hans Nauwynck; Sarah Glorieux; Nina Van Opdenbosch; Nick De Regge
Journal: Vet Microbiol Date: 2010-02-11 Impact factor: 3.293

5. Reversible conformational change in herpes simplex virus glycoprotein B with fusion-from-without activity is triggered by mildly acidic pH.

Authors: Carlos R Siekavizza-Robles; Stephen J Dollery; Anthony V Nicola
Journal: Virol J Date: 2010-12-01 Impact factor: 4.099

6. {alpha}V{beta}3-integrin routes herpes simplex virus to an entry pathway dependent on cholesterol-rich lipid rafts and dynamin2.

Authors: Tatiana Gianni; Valentina Gatta; Gabriella Campadelli-Fiume
Journal: Proc Natl Acad Sci U S A Date: 2010-12-06 Impact factor: 11.205

7. Glycoprotein H and α4β1 integrins determine the entry pathway of alphaherpesviruses.

Authors: Walid Azab; Maik J Lehmann; Nikolaus Osterrieder
Journal: J Virol Date: 2013-03-20 Impact factor: 5.103

8. Entry pathways of herpes simplex virus type 1 into human keratinocytes are dynamin- and cholesterol-dependent.

Authors: Elena Rahn; Philipp Petermann; Mei-Ju Hsu; Frazer J Rixon; Dagmar Knebel-Mörsdorf
Journal: PLoS One Date: 2011-10-12 Impact factor: 3.240

9. Plasma membrane cholesterol is required for efficient pseudorabies virus entry.

Authors: Ann S Desplanques; Hans J Nauwynck; Dries Vercauteren; Tom Geens; Herman W Favoreel
Journal: Virology Date: 2008-05-08 Impact factor: 3.616

10. Bacterial colonization of host cells in the absence of cholesterol.

Authors: Stacey D Gilk; Diane C Cockrell; Courtney Luterbach; Bryan Hansen; Leigh A Knodler; J Antonio Ibarra; Olivia Steele-Mortimer; Robert A Heinzen
Journal: PLoS Pathog Date: 2013-01-24 Impact factor: 6.823

12 in total

1. US3 Kinase-Mediated Phosphorylation of Tegument Protein VP8 Plays a Critical Role in the Cellular Localization of VP8 and Its Effect on the Lipid Metabolism of Bovine Herpesvirus 1-Infected Cells.

Authors: Kuan Zhang; Tara Donovan; Soumya Sucharita; Robert Brownlie; Marlene Snider; Suresh K Tikoo; Sylvia van Drunen Littel-van den Hurk
Journal: J Virol Date: 2019-03-05 Impact factor: 5.103

Review 2. Herpes simplex virus Membrane Fusion.

Authors: Darin J Weed; Anthony V Nicola
Journal: Adv Anat Embryol Cell Biol Date: 2017 Impact factor: 1.231

3. Cellular Cholesterol Facilitates the Postentry Replication Cycle of Herpes Simplex Virus 1.

Authors: George A Wudiri; Anthony V Nicola
Journal: J Virol Date: 2017-06-26 Impact factor: 5.103

4. Mildly Acidic pH Triggers an Irreversible Conformational Change in the Fusion Domain of Herpes Simplex Virus 1 Glycoprotein B and Inactivation of Viral Entry.

Authors: Darin J Weed; Suzanne M Pritchard; Floricel Gonzalez; Hector C Aguilar; Anthony V Nicola
Journal: J Virol Date: 2017-02-14 Impact factor: 5.103

5. Structure-Function Dissection of Pseudorabies Virus Glycoprotein B Fusion Loops.

Authors: Melina Vallbracht; Delphine Brun; Matteo Tassinari; Marie-Christine Vaney; Gérard Pehau-Arnaudet; Pablo Guardado-Calvo; Ahmed Haouz; Barbara G Klupp; Thomas C Mettenleiter; Felix A Rey; Marija Backovic
Journal: J Virol Date: 2017-12-14 Impact factor: 5.103