| Literature DB >> 20197219 |
Herman W Favoreel1, Céline Van den Broeke, Ann Desplanques, Matthias Deruelle, Geert Van Minnebruggen, Hans Nauwynck, Sarah Glorieux, Nina Van Opdenbosch, Nick De Regge.
Abstract
Two major structural elements of a cell are the cytoskeleton and the lipid membranes. Actin and cholesterol are key components of the cytoskeleton and membranes, respectively, and are involved in a plethora of different cellular processes. This review summarizes and discusses the interaction of alphaherpesviruses with actin and cholesterol during different stages of the replication cycle: virus entry, replication and assembly in the nucleus, and virus egress. Elucidating these interactions not only yields novel insights into the biology of these important pathogens, but may also shed new light on cell biological aspects of actin and cholesterol, and lead to novel avenues in the design of antiviral strategies. Copyright 2010 Elsevier B.V. All rights reserved.Entities:
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Year: 2010 PMID： 20197219 DOI： 10.1016/j.vetmic.2010.02.007
Source DB: PubMed Journal: Vet Microbiol ISSN： 0378-1135 Impact factor: 3.293