Literature DB >> 2523001

Limited temperature-sensitive transactivation by mutant adenovirus type 2 E1a proteins.

M L Fahnestock1, J B Lewis.   

Abstract

A series of linker-scanning and deletion mutations was generated in the transactivating domain of the larger, 289-amino-acid-residue E1a protein of adenovirus type 2. Mutant genes were recombined into virus to assay the ability of the variant E1a proteins to activate expression of an E1a-dependent viral gene during infection. Results of assays performed at 32, 37, and 40 degrees C indicated that at least 2 of the 10 mutants tested showed limited temperature sensitivity for transactivation.

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Year:  1989        PMID： 2523001      PMCID： PMC250655     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  19 in total

1.  Genetic dissection of the transactivating domain of the E1a 289R protein of adenovirus type 2.

Authors:  M L Fahnestock; J B Lewis
Journal:  J Virol       Date:  1989-04       Impact factor: 5.103

2.  An adenovirus type 5 early gene function regulates expression of other early viral genes.

Authors:  N Jones; T Shenk
Journal:  Proc Natl Acad Sci U S A       Date:  1979-08       Impact factor: 11.205

3.  Transcriptional control signals of a eukaryotic protein-coding gene.

Authors:  S L McKnight; R Kingsbury
Journal:  Science       Date:  1982-07-23       Impact factor: 47.728

4.  Deletion and insertion mutations in early region 1a of type 5 adenovirus that produce cold-sensitive or defective phenotypes for transformation.

Authors:  L E Babiss; P B Fisher; H S Ginsberg
Journal:  J Virol       Date:  1984-03       Impact factor: 5.103

5.  Resolving the functions of overlapping viral genes by site-specific mutagenesis at a mRNA splice site.

Authors:  C Montell; E F Fisher; M H Caruthers; A J Berk
Journal:  Nature       Date:  1982-02-04       Impact factor: 49.962

6.  Isolation of type 5 adenovirus mutants with a cold-sensitive host range phenotype: genetic evidence of an adenovirus transformation maintenance function.

Authors:  Y S Ho; R Galos; J Williams
Journal:  Virology       Date:  1982-10-15       Impact factor: 3.616

7.  Analysis of adenovirus transforming proteins from early regions 1A and 1B with antisera to inducible fusion antigens produced in Escherichia coli.

Authors:  K R Spindler; D S Rosser; A J Berk
Journal:  J Virol       Date:  1984-01       Impact factor: 5.103

8.  Isolation of adenovirus type 5 host range deletion mutants defective for transformation of rat embryo cells.

Authors:  N Jones; T Shenk
Journal:  Cell       Date:  1979-07       Impact factor: 41.582

9.  Expression of early adenovirus genes requires a viral encoded acidic polypeptide.

Authors:  R P Ricciardi; R L Jones; C L Cepko; P A Sharp; B E Roberts
Journal:  Proc Natl Acad Sci U S A       Date:  1981-10       Impact factor: 11.205

10.  Adenovirus 2 early region 1A stimulates expression of both viral and cellular genes.

Authors:  C Svensson; G Akusjärvi
Journal:  EMBO J       Date:  1984-04       Impact factor: 11.598
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