OBJECTIVES: The objective of this study was to perform a meta-analysis investigating antibiotic exposure as a risk factor for developing inflammatory bowel disease (IBD). METHODS: A literature search using Medline, Embase, and Cochrane databases was performed to identify studies providing data on the association between antibiotic use and newly diagnosed IBD. Included studies reported Crohn's disease (CD), ulcerative colitis (UC), or a composite of both (IBD) as the primary outcome and evaluated antibiotic exposure before being diagnosed with IBD. A random-effects meta-analysis was conducted to determine overall pooled estimates and 95% confidence intervals (CIs). RESULTS: A total of 11 observational studies (8 case-control and 3 cohort) including 7,208 patients diagnosed with IBD were analyzed. The pooled odds ratio (OR) for IBD among patients exposed to any antibiotic was 1.57 (95% CI 1.27-1.94). Antibiotic exposure was significantly associated with CD (OR 1.74, 95% CI 1.35-2.23) but was not significant for UC (OR 1.08, 95% CI 0.91-1.27). Exposure to antibiotics most markedly increased the risk of CD in children (OR 2.75, 95% CI 1.72-4.38). All antibiotics were associated with IBD, with the exception of penicillin. Exposure to metronidazole (OR 5.01, 95% CI 1.65-15.25) or fluoroquinolones (OR 1.79, 95% CI 1.03-3.12) was most strongly associated with new-onset IBD. CONCLUSIONS: Exposure to antibiotics appears to increase the odds of being newly diagnosed with CD but not UC. This risk is most marked in children diagnosed with CD.
OBJECTIVES: The objective of this study was to perform a meta-analysis investigating antibiotic exposure as a risk factor for developing inflammatory bowel disease (IBD). METHODS: A literature search using Medline, Embase, and Cochrane databases was performed to identify studies providing data on the association between antibiotic use and newly diagnosed IBD. Included studies reported Crohn's disease (CD), ulcerative colitis (UC), or a composite of both (IBD) as the primary outcome and evaluated antibiotic exposure before being diagnosed with IBD. A random-effects meta-analysis was conducted to determine overall pooled estimates and 95% confidence intervals (CIs). RESULTS: A total of 11 observational studies (8 case-control and 3 cohort) including 7,208 patients diagnosed with IBD were analyzed. The pooled odds ratio (OR) for IBD among patients exposed to any antibiotic was 1.57 (95% CI 1.27-1.94). Antibiotic exposure was significantly associated with CD (OR 1.74, 95% CI 1.35-2.23) but was not significant for UC (OR 1.08, 95% CI 0.91-1.27). Exposure to antibiotics most markedly increased the risk of CD in children (OR 2.75, 95% CI 1.72-4.38). All antibiotics were associated with IBD, with the exception of penicillin. Exposure to metronidazole (OR 5.01, 95% CI 1.65-15.25) or fluoroquinolones (OR 1.79, 95% CI 1.03-3.12) was most strongly associated with new-onset IBD. CONCLUSIONS: Exposure to antibiotics appears to increase the odds of being newly diagnosed with CD but not UC. This risk is most marked in children diagnosed with CD.
Authors: Silvia Ghione; Hélène Sarter; Mathurin Fumery; Laura Armengol-Debeir; Guillaume Savoye; Delphine Ley; Claire Spyckerelle; Benjamin Pariente; Laurent Peyrin-Biroulet; Dominique Turck; Corinne Gower-Rousseau; J M Andre; M Antonietti; A Aouakli; A Armand; I Aroichane; F Assi; J P Aubet; E Auxenfants; F Ayafi-Ramelot; D Bankovski; B Barbry; N Bardoux; P Baron; A Baudet; B Bazin; A Bebahani; J P Becqwort; V Benet; H Benali; C Benguigui; Ben E Soussan; A Bental; I Berkelmans; J Bernet; K Bernou; C Bernou-Dron; P Bertot; N Bertiaux-Vandaële; V Bertrand; E Billoud; N Biron; B Bismuth; M Bleuet; F Blondel; V Blondin; P Bohon; E Boniface; P Bonnière; E Bonvarlet; P Bonvarlet; A Boruchowicz; R Bostvironnois; M Boualit; B Bouche; C Boudaillez; C Bourgeaux; M Bourgeois; A Bourguet; A Bourienne; J Branche; G Bray; F Brazier; P Breban; H Brihier; V Brung-Lefebvre; P Bulois; P Burgiere; J Butel; J Y Canva; V Canva-Delcambre; J P Capron; F Cardot; P Carpentier; E Cartier; J F Cassar; M Cassagnou; J F Castex; P Catala; S Cattan; S Catteau; B Caujolle; G Cayron; C Chandelier; M Chantre; J Charles; T Charneau; M Chavance-Thelu; D Chirita; A Choteau; J F Claerbout; P Y Clergue; H Coevoet; G Cohen; R Collet; J F Colombel; S Coopman; J Corvisart; A Cortot; F Couttenier; J F Crinquette; V Crombe; I Dadamessi; V Dapvril; T Davion; S Dautreme; J Debas; N Degrave; F Dehont; C Delatre; R Delcenserie; O Delette; T Delgrange; L Delhoustal; J S Delmotte; S Demmane; G Deregnaucourt; P Descombes; J P Desechalliers; P Desmet; P Desreumaux; G Desseaux; P Desurmont; A Devienne; E Devouge; M Devred; A Devroux; A Dewailly; S Dharancy; A Di Fiore; D Djeddi; R Djedir; M L Dreher-Duwat; R Dubois; C Dubuque; P Ducatillon; J Duclay; B Ducrocq; F Ducrot; P Ducrotte; A Dufilho; C Duhamel; D Dujardin; C Dumant-Forest; J L Dupas; F Dupont; Y Duranton; A Duriez; K El Achkar; M El Farisi; C Elie; M C Elie-Legrand; A Elkhaki; M Eoche; D Evrard; J P Evrard; A Fatome; B Filoche; L Finet; M Flahaut; C Flamme; D Foissey; P Fournier; M C Foutrein-Comes; P Foutrein; D Fremond; T Frere; M Fumery; P Gallet; C Gamblin; P S Ganga-Zandzou; R Gérard; G Geslin; Y Gheyssens; N Ghossini; S Ghrib; T Gilbert; B Gillet; D Godard; P Godard; J M Godchaux; R Godchaux; G Goegebeur; O Goria; F Gottrand; P Gower; B Grandmaison; M Groux; C Guedon; J F Guillard; L Guillem; F Guillemot; D Guimber; B Haddouche; S Hakim; D Hanon; V Hautefeuille; P Heckestweiller; G Hecquet; J P Hedde; H Hellal; P E Henneresse; B Heyman; M Heraud; S Herve; P Hochain; L Houssin-Bailly; P Houcke; B Huguenin; S Iobagiu; A Ivanovic; I Iwanicki-Caron; E Janicki; M Jarry; J Jeu; J P Joly; C Jonas; F Katherin; A Kerleveo; A Khachfe; A Kiriakos; J Kiriakos; O Klein; M Kohut; R Kornhauser; D Koutsomanis; J E Laberenne; G Laffineur; M Lagarde; P Lannoy; J Lapchin; M Lapprand; D Laude; R Leblanc; P Lecieux; N Leclerc; C Le Couteulx; J Ledent; J Lefebvre; P Lefiliatre; C Legrand; A Le Grix; P Lelong; B Leluyer; C Lenaerts; L Lepileur; A Leplat; E Lepoutre-Dujardin; H Leroi; M Y Leroy; J P Lesage; X Lesage; J Lesage; I Lescanne-Darchis; J Lescut; D Lescut; B Leurent; P Levy; M Lhermie; A Lion; B Lisambert; F Loire; S Louf; A Louvet; M Luciani; D Lucidarme; J Lugand; O Macaigne; D Maetz; D Maillard; H Mancheron; O Manolache; A B Marks-Brunel; R Marti; F Martin; G Martin; E Marzloff; P Mathurin; J Mauillon; V Maunoury; J L Maupas; B Mesnard; P Metayer; L Methari; B Meurisse; F Meurisse; L Michaud; X Mirmaran; P Modaine; A Monthe; L Morel; P E Mortier; E Moulin; O Mouterde; J Mudry; M Nachury; NʼGuyen E Khac; B Notteghem; V Ollevier; A Ostyn; A Ouraghi; D Ouvry; B Paillot; N Panien-Claudot; C Paoletti; A Papazian; B Parent; B Pariente; J C Paris; P Patrier; L Paupart; B Pauwels; M Pauwels; R Petit; M Piat; S Piotte; C Plane; B Plouvier; E Pollet; P Pommelet; D Pop; C Pordes; G Pouchain; P Prades; A Prevost; J C Prevost; B Quesnel; A M Queuniet; J F Quinton; A Rabache; P Rabelle; G Raclot; S Ratajczyk; D Rault; V Razemon; N Reix; M Revillon; C Richez; P Robinson; J Rodriguez; J Roger; J M Roux; A Rudelli; A Saber; G Savoye; P Schlosseberg; M Segrestin; D Seguy; M Serin; A Seryer; F Sevenet; N Shekh; J Silvie; V Simon; C Spyckerelle; N Talbodec; A Techy; J L Thelu; A Thevenin; H Thiebault; J Thomas; J M Thorel; G Tielman; M Tode; J Toisin; J Tonnel; J Y Touchais; Y Touze; J L Tranvouez; C Triplet; D Turck; S Uhlen; E Vaillant; C Valmage; D Vanco; H Vandamme; E Vanderbecq; Vander E Eecken; P Vandermolen; P Vandevenne; L Vandeville; A Vandewalle; C Vandewalle; P Vaneslander; J P Vanhoove; A Vanrenterghem; P Varlet; I Vasies; G Verbiese; G Vernier-Massouille; P Vermelle; C Verne; P Vezilier-Cocq; B Vigneron; M Vincendet; J Viot; Y M Voiment; A Wacrenier; L Waeghemaecker; J Y Wallez; M Wantiez; F Wartel; J Weber; J L Willocquet; N Wizla; E Wolschies; A Zalar; B Zaouri; A Zellweger; C Ziade Journal: Am J Gastroenterol Date: 2017-08-15 Impact factor: 10.864
Authors: Matthew L Wheeler; Jose J Limon; Agnieszka S Bar; Christian A Leal; Matthew Gargus; Jie Tang; Jordan Brown; Vincent A Funari; Hanlin L Wang; Timothy R Crother; Moshe Arditi; David M Underhill; Iliyan D Iliev Journal: Cell Host Microbe Date: 2016-05-26 Impact factor: 21.023
Authors: Mariabeatrice Principi; Nicoletta Cassano; Antonella Contaldo; Andrea Iannone; Giuseppe Losurdo; Michele Barone; Mario Mastrolonardo; Gino Antonio Vena; Enzo Ierardi; Alfredo Di Leo Journal: World J Gastroenterol Date: 2016-05-28 Impact factor: 5.742