Laura Gaudet1, Shi Wu Wen2, Mark Walker3. 1. Faculty of Medicine, University of Ottawa, Ottawa ON; Department of Obstetrics and Gynecology, The Ottawa Hospital, Ottawa ON; Horizon Health Network, Moncton NB; Ottawa Health Research Institute, Ottawa ON. 2. Faculty of Medicine, University of Ottawa, Ottawa ON; Ottawa Health Research Institute, Ottawa ON. 3. Faculty of Medicine, University of Ottawa, Ottawa ON; Department of Obstetrics and Gynecology, The Ottawa Hospital, Ottawa ON; Ottawa Health Research Institute, Ottawa ON.
Abstract
OBJECTIVE: To examine the combined effect of macrosomia and maternal obesity on adverse pregnancy outcomes using a retrospective cohort. METHODS: Infants with a birth weight of ≥ 4000g (macrosomia) were identified from an institutional birth cohort. Demographic characteristics and maternal, fetal, neonatal, and pregnancy outcomes of macrosomic infants whose mothers were obese were compared with those whose mothers were non-obese. RESULTS: Pregnancies in obese women resulting in macrosomic infants are more likely to be complicated by gestational diabetes, gestational hypertension, and smoking than pregnancies in non-obese women with macrosomic infants. Mothers whose infants are macrosomic are significantly more likely to require induction of labour (OR 1.42; 95% CI 1.10 to 1.98) and delivery by Caesarean section (OR 1.45; 95% CI 1.04 to 2.01), particularly for maternal indications (OR 3.7; 95% CI 1.47 to 9.34), if they are obese. Finally, macrosomic infants of obese mothers are significantly more likely to require neonatal resuscitation in the form of free flow oxygen (OR 1.57; 95% CI 1.03 to 2.42) than macrosomic infants of non-obese mothers. CONCLUSION: When both maternal obesity and macrosomia are present, adverse pregnancy outcomes are more common than when fetal macrosomia occurs in a woman of normal weight.
OBJECTIVE: To examine the combined effect of macrosomia and maternal obesity on adverse pregnancy outcomes using a retrospective cohort. METHODS:Infants with a birth weight of ≥ 4000g (macrosomia) were identified from an institutional birth cohort. Demographic characteristics and maternal, fetal, neonatal, and pregnancy outcomes of macrosomic infants whose mothers were obese were compared with those whose mothers were non-obese. RESULTS: Pregnancies in obesewomen resulting in macrosomic infants are more likely to be complicated by gestational diabetes, gestational hypertension, and smoking than pregnancies in non-obesewomen with macrosomic infants. Mothers whose infants are macrosomic are significantly more likely to require induction of labour (OR 1.42; 95% CI 1.10 to 1.98) and delivery by Caesarean section (OR 1.45; 95% CI 1.04 to 2.01), particularly for maternal indications (OR 3.7; 95% CI 1.47 to 9.34), if they are obese. Finally, macrosomic infants of obese mothers are significantly more likely to require neonatal resuscitation in the form of free flow oxygen (OR 1.57; 95% CI 1.03 to 2.42) than macrosomic infants of non-obese mothers. CONCLUSION: When both maternal obesity and macrosomia are present, adverse pregnancy outcomes are more common than when fetal macrosomia occurs in a woman of normal weight.
Entities:
Keywords:
body mass index; fetal macrosomia; obesity; pregnancy; pregnancy outcome
Authors: Virginia A Aparicio; Olga Ocón; Carmen Padilla-Vinuesa; Alberto Soriano-Maldonado; Lidia Romero-Gallardo; Milkana Borges-Cósic; Irene Coll-Risco; Pilar Ruiz-Cabello; Pedro Acosta-Manzano; Fernando Estévez-López; Inmaculada C Álvarez-Gallardo; Manuel Delgado-Fernández; Jonatan R Ruiz; Mireille N Van Poppel; Julio J Ochoa-Herrera Journal: BMC Pregnancy Childbirth Date: 2016-09-29 Impact factor: 3.007