Literature DB >> 25220425

Regulation of hematopoietic stem cell aging by the small RhoGTPase Cdc42.

Hartmut Geiger1, Yi Zheng2.   

Abstract

Aging of stem cells might be the underlying cause of tissue aging in tissue that in the adult heavily rely on stem cell activity, like the blood forming system. Hematopoiesis, the generation of blood forming cells, is sustained by hematopoietic stem cells. In this review article, we introduce the canonical set of phenotypes associated with aged HSCs, focus on the novel aging-associated phenotype apolarity caused by elevated activity of the small RhoGTPase in aged HSCs, discuss the role of Cdc42 in hematopoiesis and describe that pharmacological inhibition of Cdc42 activity in aged HSCs results in functionally young and thus rejuvenated HSCs.
Copyright © 2014 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Cdc42; Ging; Hematopoiesis; Polarity; Stem Cell

Mesh：

Substances：

Year:  2014        PMID： 25220425      PMCID： PMC4427663          DOI： 10.1016/j.yexcr.2014.09.001

Source DB:  PubMed          Journal:  Exp Cell Res        ISSN： 0014-4827            Impact factor:   3.905


  67 in total

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