Literature DB >> 25220415

The role of poly(ADP-ribosyl)ation in DNA damage response and cancer chemotherapy.

M Li1, X Yu2.   

Abstract

DNA damage is a deleterious threat, but occurs daily in all types of cells. In response to DNA damage, poly(ADP-ribosyl)ation, a unique post-translational modification, is immediately catalyzed by poly(ADP-ribose) polymerases (PARPs) at DNA lesions, which facilitates DNA damage repair. Recent studies suggest that poly(ADP-ribosyl)ation is one of the first steps of cellular DNA damage response and governs early DNA damage response pathways. Suppression of DNA damage-induced poly(ADP-ribosyl)ation by PARP inhibitors impairs early DNA damage response events. Moreover, PARP inhibitors are emerging as anti-cancer drugs in phase III clinical trials for BRCA-deficient tumors. In this review, we discuss recent findings on poly(ADP-ribosyl)ation in DNA damage response as well as the molecular mechanism by which PARP inhibitors selectively kill tumor cells with BRCA mutations.

Entities:  

Mesh：

Substances：

Year:  2014        PMID： 25220415      PMCID： PMC4362780          DOI： 10.1038/onc.2014.295

Source DB:  PubMed          Journal:  Oncogene        ISSN： 0950-9232            Impact factor:   9.867


  142 in total

1.  Molecular cloning of the human gene, PNKP, encoding a polynucleotide kinase 3'-phosphatase and evidence for its role in repair of DNA strand breaks caused by oxidative damage.

Authors:  A Jilani; D Ramotar; C Slack; C Ong; X M Yang; S W Scherer; D D Lasko
Journal:  J Biol Chem       Date:  1999-08-20       Impact factor: 5.157

Review 2.  Dynamics and diversions in base excision DNA repair of oxidized abasic lesions.

Authors:  Bruce Demple; Michael S DeMott
Journal:  Oncogene       Date:  2002-12-16       Impact factor: 9.867

Review 3.  Protein-protein interactions during mammalian DNA single-strand break repair.

Authors:  K W Caldecott
Journal:  Biochem Soc Trans       Date:  2003-02       Impact factor: 5.407

4.  Identification of a RING protein that can interact in vivo with the BRCA1 gene product.

Authors:  L C Wu; Z W Wang; J T Tsan; M A Spillman; A Phung; X L Xu; M C Yang; L Y Hwang; A M Bowcock; R Baer
Journal:  Nat Genet       Date:  1996-12       Impact factor: 38.330

5.  Characterization of polymers of adenosine diphosphate ribose generated in vitro and in vivo.

Authors:  R Alvarez-Gonzalez; M K Jacobson
Journal:  Biochemistry       Date:  1987-06-02       Impact factor: 3.162

6.  PARP1-dependent kinetics of recruitment of MRE11 and NBS1 proteins to multiple DNA damage sites.

Authors:  Jean-François Haince; Darin McDonald; Amélie Rodrigue; Ugo Déry; Jean-Yves Masson; Michael J Hendzel; Guy G Poirier
Journal:  J Biol Chem       Date:  2007-11-19       Impact factor: 5.157

7.  Poly(ADP-ribose)-binding zinc finger motifs in DNA repair/checkpoint proteins.

Authors:  Ivan Ahel; Dragana Ahel; Takahiro Matsusaka; Allison J Clark; Jonathon Pines; Simon J Boulton; Stephen C West
Journal:  Nature       Date:  2008-01-03       Impact factor: 49.962

8.  A core hSSB1-INTS complex participates in the DNA damage response.

Authors:  Feng Zhang; Teng Ma; Xiaochun Yu
Journal:  J Cell Sci       Date:  2013-08-28       Impact factor: 5.285

Review 9.  Mechanisms of resistance to therapies targeting BRCA-mutant cancers.

Authors:  Christopher J Lord; Alan Ashworth
Journal:  Nat Med       Date:  2013-10-07       Impact factor: 53.440

10.  A family of macrodomain proteins reverses cellular mono-ADP-ribosylation.

Authors:  Gytis Jankevicius; Markus Hassler; Barbara Golia; Vladimir Rybin; Martin Zacharias; Gyula Timinszky; Andreas G Ladurner
Journal:  Nat Struct Mol Biol       Date:  2013-03-10       Impact factor: 15.369
View more
  50 in total

1.  A Systematic Analysis of Factors Localized to Damaged Chromatin Reveals PARP-Dependent Recruitment of Transcription Factors.

Authors:  Lior Izhar; Britt Adamson; Alberto Ciccia; Jedd Lewis; Laura Pontano-Vaites; Yumei Leng; Anthony C Liang; Thomas F Westbrook; J Wade Harper; Stephen J Elledge
Journal:  Cell Rep       Date:  2015-05-21       Impact factor: 9.423

2.  PARP1-dependent recruitment of the FBXL10-RNF68-RNF2 ubiquitin ligase to sites of DNA damage controls H2A.Z loading.

Authors:  Gergely Rona; Domenico Roberti; Yandong Yin; Julia K Pagan; Harrison Homer; Elizabeth Sassani; Andras Zeke; Luca Busino; Eli Rothenberg; Michele Pagano
Journal:  Elife       Date:  2018-07-09       Impact factor: 8.140

Review 3.  CREBBP and p300 lysine acetyl transferases in the DNA damage response.

Authors:  Ilaria Dutto; Claudia Scalera; Ennio Prosperi
Journal:  Cell Mol Life Sci       Date:  2017-11-23       Impact factor: 9.261

4.  A phase I/II study of veliparib (ABT-888) with radiation and temozolomide in newly diagnosed diffuse pontine glioma: a Pediatric Brain Tumor Consortium study.

Authors:  Patricia A Baxter; Jack M Su; Arzu Onar-Thomas; Catherine A Billups; Xiao-Nan Li; Tina Young Poussaint; Edward R Smith; Patrick Thompson; Adekunle Adesina; Pete Ansell; Vincent Giranda; Arnold Paulino; Lindsey Kilburn; Ibrahim Quaddoumi; Alberto Broniscer; Susan M Blaney; Ira J Dunkel; Maryam Fouladi
Journal:  Neuro Oncol       Date:  2020-06-09       Impact factor: 12.300

5.  Dual-Modality Optical/PET Imaging of PARP1 in Glioblastoma.

Authors:  Giuseppe Carlucci; Brandon Carney; Christian Brand; Susanne Kossatz; Christopher P Irwin; Sean D Carlin; Edmund J Keliher; Wolfgang Weber; Thomas Reiner
Journal:  Mol Imaging Biol       Date:  2015-12       Impact factor: 3.488

Review 6.  Evaluation of rucaparib and companion diagnostics in the PARP inhibitor landscape for recurrent ovarian cancer therapy.

Authors:  Zachary B Jenner; Anil K Sood; Robert L Coleman
Journal:  Future Oncol       Date:  2016-04-18       Impact factor: 3.404

Review 7.  Trial watch - inhibiting PARP enzymes for anticancer therapy.

Authors:  Antonella Sistigu; Gwenola Manic; Florine Obrist; Ilio Vitale
Journal:  Mol Cell Oncol       Date:  2015-06-10

8.  Prostate cancer: unmet clinical needs and RAD9 as a candidate biomarker for patient management.

Authors:  Howard B Lieberman; Alex J Rai; Richard A Friedman; Kevin M Hopkins; Constantinos G Broustas
Journal:  Transl Cancer Res       Date:  2018-01-14       Impact factor: 1.241

9.  Characterization and DNA methylation modulatory activity of gold nanoparticles synthesized by Pseudoalteromonas strain.

Authors:  Yugandhara M Patil; Shriram N Rajpathak; Deepti D Deobagkar
Journal:  J Biosci       Date:  2019-03       Impact factor: 1.826

10.  A Cell-Line-Specific Atlas of PARP-Mediated Protein Asp/Glu-ADP-Ribosylation in Breast Cancer.

Authors:  Yuanli Zhen; Yajie Zhang; Yonghao Yu
Journal:  Cell Rep       Date:  2017-11-21       Impact factor: 9.423
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.