| Literature DB >> 25218180 |
Johannes Alneberg1, Brynjar Smári Bjarnason1, Ino de Bruijn2, Melanie Schirmer3, Joshua Quick4, Umer Z Ijaz3, Leo Lahti5, Nicholas J Loman6, Anders F Andersson1, Christopher Quince7.
Abstract
Shotgun sequencing enables the reconstruction of genomes from complex microbial communities, but because assembly does not reconstruct entire genomes, it is necessary to bin genome fragments. Here we present CONCOCT, a new algorithm that combines sequence composition and coverage across multiple samples, to automatically cluster contigs into genomes. We demonstrate high recall and precision on artificial as well as real human gut metagenome data sets.Entities:
Mesh:
Year: 2014 PMID: 25218180 DOI: 10.1038/nmeth.3103
Source DB: PubMed Journal: Nat Methods ISSN: 1548-7091 Impact factor: 28.547