| Literature DB >> 25216413 |
Tadahiro Nozoe1, Rumi Matono, Hideki Ijichi, Takefumi Ohga, Takahiro Ezaki.
Abstract
The Glasgow Prognostic Score (GPS), an inflammation-based score, has been used to predict the biologic behavior of malignant tumors. The aim of the current study was to elucidate a further significance of GPS in colorectal carcinoma. Correlation of GPS and modified GPS (mGPS), which are composed of combined score provided for serum elevation of C-reactive protein and hypoalbuminemia examined before surgical treatment, with clinicopathologic features was investigated in 272 patients with colorectal carcinoma. Survival of GPS 1 patients was significantly worse than that of GPS 0 patients (P= 0.009), and survival of GPS 2 patients was significantly worse than that of GPS 1 patients (P < 0.0001). Similarly, survival of mGPS 1 patients was significantly worse than that of mGPS 0 patients (P = 0.009), and survival of mGPS 2 patients was significantly worse than that of mGPS 1 patients (P = 0.0006). Multivariate analysis demonstrated that GPS (P < 0.0001) as well as tumor stage (P= 0.004) and venous invasion (P = 0.011) were factors independently associated with worse prognosis. Both GPS and mGPS could classify outcome of patients with a clear stratification, and could be applied as prognostic indicators in colorectal carcinoma.Entities:
Keywords: Colorectal carcinoma; Glasgow prognostic score (GPS); Prognostic indicator
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Year: 2014 PMID： 25216413 PMCID： PMC4253916 DOI： 10.9738/INTSURG-D-13-00118.1
Source DB: PubMed Journal: Int Surg ISSN： 0020-8868