| Literature DB >> 25212799 |
Matthijs van Kranenburg1, Michael Magro2, Holger Thiele3, Suzanne de Waha4, Ingo Eitel3, Alexandre Cochet5, Yves Cottin6, Dan Atar7, Peter Buser8, Edwin Wu9, Daniel Lee9, Vicente Bodi10, Gert Klug11, Bernhard Metzler11, Ronak Delewi12, Peter Bernhardt13, Wolfgang Rottbauer13, Eric Boersma2, Felix Zijlstra2, Robert-Jan van Geuns14.
Abstract
The aim of this study was to evaluate the value of microvascular obstruction (MO) and infarct size as a percentage of left ventricular mass (IS%LV), as measured by contrast-enhanced cardiac magnetic resonance, in predicting major cardiovascular adverse events (MACE) at 2 years in patients with ST-segment elevation myocardial infarction reperfused by primary percutaneous coronary intervention. Individual data from 1,025 patients were entered into the pooled analysis. MO was associated with the occurrence of MACE, defined as a composite of cardiac death, congestive heart failure, and myocardial re-infarction (adjusted hazard ratio: 3.74; 95% confidence interval: 2.21 to 6.34). IS%LV ≥25% was not associated with MACE (adjusted hazard ratio: 0.90; 95% confidence interval: 0.59 to 1.37). The authors conclude that MO is an independent predictor of MACE and cardiac death, whereas IS%LV is not independently associated with MACE.Entities:
Keywords: cardiac magnetic resonance; infarct size; microvascular obstruction; myocardial infarction; prognosis
Mesh：
Year: 2014 PMID： 25212799 DOI： 10.1016/j.jcmg.2014.05.010
Source DB: PubMed Journal: JACC Cardiovasc Imaging ISSN： 1876-7591