Alessandro Di Cerbo1, Sergio Canello2, Gianandrea Guidetti3, Carmen Laurino4, Beniamino Palmieri5. 1. Poliambulatorio del Secondo Parere. Department of Consultation and Coordination. Viale Reiter 14. 41225 Modena. Italy.. alessandro811@hotmail.it. 2. Via Euganea villa 1 - villa di teolo. 35037 Padova. Italy.. Sergio.canello.5@facebook.com. 3. Via Alfonso Chierici 1. 42121 Reggio Emilia. Italy.. gianandrea.guidetti@gmail.com. 4. Azienda Ospedaliero-Universitaria Policlinico di Modena. Surgery and Surgical Specialties department. University of Modena and Reggio Emilia. Via del Pozzo 71. 41124 Modena. Italy.. Carmen.laurino@hotmail.it. 5. Azienda Ospedaliero-Universitaria Policlinico di Modena. Surgery and Surgical Specialties department. University of Modena and Reggio Emilia. Via del Pozzo 71. 41124 Modena. Italy.. palmieri@unimo.it.
Abstract
INTRODUCTION: Great interest is raising in food intolerances due to the lack, in many cases, of a particular sensitizing agent. OBJECTIVE: We investigated the serum level of possible new haptens in 15 heavy meat consumers for sport fitness affected by various kinds of food intolerance and who had ever been administered antibiotics in their life for clinical problems. METHODS: Forty ml of blood were drawn from each patient and analyzed, by means of an ELISA test, in order to possibly identify the presence of an undue contaminant with hapten properties. RESULTS: Four out of fifteen subjects (26%) showed a serum oxytetracycline amount > 6 ng/g (which is considered the safety limit), 10 of 15 (66%) a serum doxycycline amount > of 6 ng/g and 3 out of 15 (30%) subjects had high serum level of both molecules. CONCLUSIONS: Although a direct ratio between body antibiotics remnant storage in the long run and chronic gut dysfunctions and/or food allergy did not reached the evidence yet, the blood traces of these compounds in a food intolerant otherwise healthy population might be considered the preliminary putative step of a sensitizing pathway. Our next goals foresee a deeper insight into the sensitizing trigger from human chronic antibiotic exposure via the zootechnical delivery of poultry food. Copyright AULA MEDICA EDICIONES 2014. Published by AULA MEDICA. All rights reserved.
INTRODUCTION: Great interest is raising in food intolerances due to the lack, in many cases, of a particular sensitizing agent. OBJECTIVE: We investigated the serum level of possible new haptens in 15 heavy meat consumers for sport fitness affected by various kinds of food intolerance and who had ever been administered antibiotics in their life for clinical problems. METHODS: Forty ml of blood were drawn from each patient and analyzed, by means of an ELISA test, in order to possibly identify the presence of an undue contaminant with hapten properties. RESULTS: Four out of fifteen subjects (26%) showed a serum oxytetracycline amount > 6 ng/g (which is considered the safety limit), 10 of 15 (66%) a serum doxycycline amount > of 6 ng/g and 3 out of 15 (30%) subjects had high serum level of both molecules. CONCLUSIONS: Although a direct ratio between body antibiotics remnant storage in the long run and chronic gut dysfunctions and/or food allergy did not reached the evidence yet, the blood traces of these compounds in a food intolerant otherwise healthy population might be considered the preliminary putative step of a sensitizing pathway. Our next goals foresee a deeper insight into the sensitizing trigger from human chronic antibiotic exposure via the zootechnical delivery of poultry food. Copyright AULA MEDICA EDICIONES 2014. Published by AULA MEDICA. All rights reserved.
Authors: R Odore; M De Marco; L Gasco; L Rotolo; V Meucci; A T Palatucci; V Rubino; G Ruggiero; S Canello; G Guidetti; S Centenaro; A Quarantelli; G Terrazzano; A Schiavone Journal: Poult Sci Date: 2015-05-25 Impact factor: 3.352
Authors: Gianandrea Guidetti; Alessandro Di Cerbo; Angela Giovazzino; Valentina Rubino; Anna Teresa Palatucci; Sara Centenaro; Elena Fraccaroli; Laura Cortese; Maria Grazia Bonomo; Giuseppina Ruggiero; Sergio Canello; Giuseppe Terrazzano Journal: J Immunol Res Date: 2016-08-15 Impact factor: 4.818
Authors: A Di Cerbo; A T Palatucci; V Rubino; S Centenaro; A Giovazzino; E Fraccaroli; L Cortese; G Ruggiero; G Guidetti; S Canello; G Terrazzano Journal: J Biochem Mol Toxicol Date: 2015-11-05 Impact factor: 3.642