A Rodriguez1,2, R García-Esteban3,4,5,6, M Basterretxea5,7,8, A Lertxundi8,9, C Rodríguez-Bernal5,10, C Iñiguez5,10,11, C Rodriguez-Dehli12, A Tardón5,13, M Espada14, J Sunyer3,4,5,6, E Morales3,4,5,6. 1. Hospital de Sabadell, Corporació Sanitària Parc Taulí, Institut Universitari ParcTaulí-UAB, Sabadell, Catalonia, Spain. 2. Universitat Autònoma de Barcelona, Campus d'Excelència Internacional Bellaterra, Catalonia, Spain. 3. Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Catalonia, Spain. 4. Hospital del Mar Medical Research Institute (IMIM), Barcelona, Catalonia, Spain. 5. CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain. 6. Universitat Pompeu Fabra (UPF), Barcelona, Catalonia, Spain. 7. Department of Health of the Basque Government, Subdirección de Salud Pública de Gipuzkoa, San Sebastian, Spain. 8. BIODONOSTIA Health Research Institute, San Sebastian, Spain. 9. Universidad del País Vasco, EHU-UPV, País Vasco, Spain. 10. Center for Public Health Research (CSISP-FISABIO), Valencia, Spain. 11. University of Valencia, Valencia, Spain. 12. Hospital San Agustín, Avilés, Spain. 13. Universidad de Oviedo, Oviedo, Spain. 14. Clinical Chemistry Unit, Public Health Laboratory of Bilbao, Euskadi, Spain.
Abstract
OBJECTIVE: To investigate the association of maternal circulating 25-hydroxyvitamin D3 [25(OH)D3] concentration with pregnancy and birth outcomes. DESIGN: Prospective cohort study. SETTING: Four geographical areas of Spain, 2003-2008. POPULATION: Of 2382 mother-child pairs participating in the INfancia y Medio Ambiente (INMA) Project. METHODS: Maternal circulating 25(OH)D3 concentration was measured in pregnancy (mean [SD] 13.5 [2.2] weeks of gestation). We tested associations of maternal 25(OH)D3 concentration with pregnancy and birth outcomes. MAIN OUTCOME MEASURES: Gestational diabetes mellitus (GDM), preterm delivery, caesarean section, fetal growth restriction (FGR) and small-for-gestational age (SGA), anthropometric birth outcomes including weight, length and head circumference (HC). RESULTS: Overall, 31.8% and 19.7% of women had vitamin D insufficiency [25(OH)D3 20-29.99 ng/ml] and deficiency [25(OH)D3 < 20 ng/ml], respectively. After adjustment, there was no association between maternal 25(OH)D3 concentration and risk of GDM or preterm delivery. Women with sufficient vitamin D [25(OH)D3 ≥ 30 ng/ml] had a decreased risk of caesarean section by obstructed labour compared with women with vitamin D deficiency [relative risk (RR) = 0.60, 95% CI 0.37, 0.97). Offspring of mothers with higher circulating 25(OH)D3 concentration tended to have smaller HC [coefficient (SE) per doubling concentration of 25(OH)D3, -0.10 (0.05), P = 0.038]. No significant associations were found for other birth outcomes. CONCLUSION: This study did not find any evidence of an association between vitamin D status in pregnancy and GDM, preterm delivery, FGR, SGA and anthropometric birth outcomes. Results suggest that sufficient circulating vitamin D concentration [25(OH)D3 ≥ 30 ng/ml] in pregnancy may reduce the risk of caesarean section by obstructed labour.
OBJECTIVE: To investigate the association of maternal circulating 25-hydroxyvitamin D3 [25(OH)D3] concentration with pregnancy and birth outcomes. DESIGN: Prospective cohort study. SETTING: Four geographical areas of Spain, 2003-2008. POPULATION: Of 2382 mother-child pairs participating in the INfancia y Medio Ambiente (INMA) Project. METHODS: Maternal circulating 25(OH)D3 concentration was measured in pregnancy (mean [SD] 13.5 [2.2] weeks of gestation). We tested associations of maternal 25(OH)D3 concentration with pregnancy and birth outcomes. MAIN OUTCOME MEASURES: Gestational diabetes mellitus (GDM), preterm delivery, caesarean section, fetal growth restriction (FGR) and small-for-gestational age (SGA), anthropometric birth outcomes including weight, length and head circumference (HC). RESULTS: Overall, 31.8% and 19.7% of women had vitamin Dinsufficiency [25(OH)D3 20-29.99 ng/ml] and deficiency [25(OH)D3 < 20 ng/ml], respectively. After adjustment, there was no association between maternal 25(OH)D3 concentration and risk of GDM or preterm delivery. Women with sufficient vitamin D [25(OH)D3 ≥ 30 ng/ml] had a decreased risk of caesarean section by obstructed labour compared with women with vitamin Ddeficiency [relative risk (RR) = 0.60, 95% CI 0.37, 0.97). Offspring of mothers with higher circulating 25(OH)D3 concentration tended to have smaller HC [coefficient (SE) per doubling concentration of 25(OH)D3, -0.10 (0.05), P = 0.038]. No significant associations were found for other birth outcomes. CONCLUSION: This study did not find any evidence of an association between vitamin D status in pregnancy and GDM, preterm delivery, FGR, SGA and anthropometric birth outcomes. Results suggest that sufficient circulating vitamin D concentration [25(OH)D3 ≥ 30 ng/ml] in pregnancy may reduce the risk of caesarean section by obstructed labour.
Authors: Spyridon N Karras; Hana Fakhoury; Giovanna Muscogiuri; William B Grant; Johannes M van den Ouweland; Anna Maria Colao; Kalliopi Kotsa Journal: Ther Adv Musculoskelet Dis Date: 2016-07-13 Impact factor: 5.346
Authors: Claire Casey; Ann McGinty; Valerie A Holmes; Chris C Patterson; Ian S Young; David R McCance Journal: Br J Nutr Date: 2018-07 Impact factor: 3.718
Authors: Kozeta Miliku; Anna Vinkhuyzen; Laura Me Blanken; John J McGrath; Darryl W Eyles; Thomas H Burne; Albert Hofman; Henning Tiemeier; Eric Ap Steegers; Romy Gaillard; Vincent Wv Jaddoe Journal: Am J Clin Nutr Date: 2016-04-20 Impact factor: 7.045
Authors: Yi Lin Ong; Phaik Ling Quah; Mya Thway Tint; Izzuddin M Aris; Ling Wei Chen; Rob M van Dam; Denise Heppe; Seang-Mei Saw; Keith M Godfrey; Peter D Gluckman; Yap Seng Chong; Fabian Yap; Yung Seng Lee; Mary Foong-Fong Chong Journal: Br J Nutr Date: 2016-06-24 Impact factor: 3.718